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1998 Fiscal Year Final Research Report Summary

Development of a less invasive and more simple interventional method to eliminate strial fibrillation and maintein the sinus rhythm.based on the mechanism of atrial fibrillation

Research Project

Project/Area Number 09671391
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Thoracic surgery
Research InstitutionIwate Medical University

Principal Investigator

CHIBA Naoki  Iwate Medical University The Second Department of Medicine, Instructor, 医学部, 助手 (80254754)

Co-Investigator(Kenkyū-buntansha) SEGAWA Ikuo  Iwate Medical University The Second Department of Medicine, Assistant Professor, 医学部, 講師 (50206611)
NASU Masataka  Iwate Medical University The Second Department of Medicine, Assistant Professor, 医学部, 講師 (20180531)
Project Period (FY) 1997 – 1998
Keywordsatrial fibrillation / maze operation / ablation / pulmonary vein / epicardial mapping / body surface mapping / electrocardiogram / impulse propagation
Research Abstract

The mechanism of origin, occurrence and maintenance of atrial fibrillation is still unclear. The maze procedure was curative with successful sinus rhythm restoration in 70 to 80% of the patients. However, we noted poor restoration of atrial mechanical transport function due to atrial pathological changes, multiple atriotomies or cryoadhesion. It is important to elucidate the mechanism of atrial fibrillation and to develop a less invasive and a more simple interventional method based on the mechanisms of atrial fibrillation.
First, intraoperative computerized activation mapping was analyzed in patients with chronic atrial fibrillation combined with isolated mitral disease in 1998. The results suggest that the mechanism of atrial fibrillation might be a simple macroreentry, and so a simple atrial fibrillation ablation may be possible in mitral disease. The previous head investigator, Yoko Yagi has developed a simple surgical ablation method consisting of only isolation of pulmonary veins, an interruption between the pulmonary veinsl. isolation line and the mitral annulus and an isthmus cryoablation alone in the right atrium in 1997. Twelve patients underwent treatment by this new method and analyzed the results in 1997.
Following the above study, we compared the diameters of pulmonary veins in patients with atrial fibrillation to those with normal sinus rhythm in 1998. The pulmonary vein orifaces in atrial fibrillation cases were larger than those in normal sinus rhythm cases. Now, we have clinically followed the most simple method consisting of pulmonary veins isolation alone.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Naoki Chiba: "DILATATION OF THE PULMONARY VEINS IN PATIENTS WITH IDIO-PATHIC ATRIAL FIBRILLATION" Supplement to Circulation. 98. 17. 1-702 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Naoki Chiba: "A NOVEL NON-INVASIVE METHOD TO ANALYZE HUMAN ATRIAL FIBRILLATION WAVE USING THE BODY SURFACE MAPPING" Supplement to Circulation. 98. 17. 1-149 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 千葉直樹: "Maze手術-トピックス-Maze手術後の心拍変動" 早川弘一・笠貫宏監修 : 心房細動・粗動 医学書院. (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masataka Nasu: "Blood Stasis in Large Left Atrium after Maze Procedure" Supplement to Circulation. 96. 8. 1-382 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 瀬川郁夫: "原因不明の慢性心房細動例の臨床病理学的検討" 心臓. 25, 9. 1013-1019 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Naoki Chiba: "DILATATION OF THE PULMONARY VEINS IN PATIENTS WITH IDIO-PATHIC ATRIAL FIBRILLATION" Suppl.of Circulation. 98-17. I-702 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Naoki Chiba: "A NOVEL NON-INVASIVE METHOD TO ANALYZE HUMAN ATRIAL FIBRILLATION WAVE USING THE BODY SURFACE MAPPING" Suppl.of Circulation. 98-17. I-149 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masataka Nasu: "BLOOD STASIS IN LARGE LEFT ATRIUM AFTER MAZE PROCEDURE" Suppl.of Circulation. 96-8. I-382 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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