1998 Fiscal Year Final Research Report Summary
The role of tenascin family molecules in brain tumors
| Project/Area Number |
09671421
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Mie University |
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Principal Investigator |
KOJIMA Tadashi Mie University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (70024651)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHIDA Toshimichi Mie University, Faculty of Medicine, Associate Professor, 医学部, 助教授 (80166959)
SAKAKURA Teruyo Mie University, Faculty of Medicine, Professor, 医学部, 教授 (80073120)
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| Project Period (FY) |
1997 – 1998
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| Keywords | glioma / tenascin-C / tenascin-R / tenascin-X / migration / proliferation / neovascularization |
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| Research Abstract |
We studied the expression of tenascin-C (TN-C), tenascin-R (TN-R), and tenascin-X (TN-X) in human gliomas to clarify the functions of tenascin family molecules in brain tumors. The distribution of TN-X was often reciprocal to that of TN-C.Cultured glioblastoma cells express a glioma-mesenchymal extracellular matrix glycoproteins, shown to be identical to TN-C, the degree of expression being linked to tumor grade in human gliomas. TN-C was more strongly expressed in the intercellular spaces and in tumor vessels in high-grade gliomas. In contrast, TN-X was mainly localized in the perivascular stroma around tumor vessels. While TN-R expression in the intercellular spaces is greater in anaplastic astrocytomas (Grade III) than inglioblastomas (Grade IV), In situ hybridization demonstrated that TN-C was produced by glioma cells and endothelial cells, and TN-R was produced only by glioma cells. Therefore TN-C may play significant roles inmigration and proliferation of glioma cells, and neovascularization. TN-X may play different roles in neovascularization, TN-C may in proliferation of glioma cells.
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