1998 Fiscal Year Final Research Report Summary
Role of VHL tumor suppressor gene in central nervous system
| Project/Area Number |
09671435
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Yokohama City University |
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Principal Investigator |
KANNO Hiroshi Yokohama City Uni., Medicine, Assist.Prof, 医学部, 講師 (40244496)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAMOTO Isao Yokohama City Uni., Medicine, Prof., 医学部, 教授 (30158266)
KAWAMOTO Susumu Yokohama City Uni., Medicine, Assist.Prof, 医学部, 講師 (80125921)
HATTORI Satoshi Yokohama City Uni., Medicine, Instructer, 医学部, 助手 (40275037)
NAGASHIMA Yoji Yokohama City Uni., Medicine, Assist.Prof, 医学部, 講師 (10217995)
YAO Masahiro Yokohama City Uni., Medicine, Assist.Prof., 医学部, 講師 (00260787)
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| Project Period (FY) |
1997 – 1998
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| Keywords | von Hippel-Lindau disease / Central nervous system / Hemangioblastoma / DNA diagnosis / Neuronal differentiation |
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| Research Abstract |
Von Hippel-Lindau disease (VHL) is an autosomal dominant hereditary disease which develops hamangioblastomas in the central nervous system and retina, renal cell carcinoma, and pheochromocytoma. The causative gene has been isolated from chromosome 3p in 1993. We have found somatic VHL gene mutations in not only sporadic hemangioblastomas and renal cell but also gliomas. In addition, we have performed molecular genetic diagnosis of 80 Japanese VHL families by the DNA analyses. The expressions of VHL gene and product were identified at neuron in the central nervous system and proximal renal tubule as well as cytoplasm of hemangiobalstoma and glioma. However, pathologically more malignant gliomas showed less expression of VHL gene produst. In process of neuronal development, VHL gene expressions were correlated with neuronal differentiation in neural stem cells. In addtion, it was suggested that cell cycle of neural stem cells were down-regulated by VHL gene.
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