1998 Fiscal Year Final Research Report Summary
Immunohistochemical and molecular-biological studies of microcystic meningiomas.
| Project/Area Number |
09671441
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
TSUNODA Shigeru Osaka Prefecture University, College of Integrated Arts and Sciences, Professor, 総合科学部, 教授 (60163862)
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| Project Period (FY) |
1997 – 1998
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| Keywords | microcystic meningioma / arachnoid trabecular cell / glutathione S-transferase-pi(GST-pi) / arachnoid trabecular cell / immunohistochemistry |
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| Research Abstract |
We proposed in 1989 the view that the microcystic meningioma represents differentiation into arachnoid trabecular cells, on the grounds that microcystic meningioma cells resemble arachnoid trabecular cells which support the normal subarachnoid space. We reported in 1995 that glutathione S-transferase-pi (GST-pi) is immunohistochemically positive in arachnoid trabecular cells of normal arachnoid villi and of microcystic meningiomas.
The present study by restriction landmark genomic scanning (RLGS) revealed an alteration on chromosome 16q where E-cadherin gene is located. And arachnoid trabecular cells were found to be positive for E-cadherin in normal arachnoid villi and microcystic meningiomas. E-cadherin is thought to play a role in the differentiation of meningiomas into microcystic components.
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