1998 Fiscal Year Final Research Report Summary
Brain tumor induction in p53 knock-out mice by transplacental carcinogen exposure.
| Project/Area Number |
09671447
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cerebral neurosurgery
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| Research Institution | Saitama Medical School |
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Principal Investigator |
NISHIKAWA Ryo Assoc. Prof., Saitama Medical School, 医学部, 助教授 (90237678)
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| Project Period (FY) |
1997 – 1998
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| Keywords | Knock-out mouse / TP53 / brain tumor / ethylnitrosourea |
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| Research Abstract |
Brain tumor induction in p53 knock-out mice by transplacental exposure to ethylnitrosourea (ENU) was attempted. Three out of 80 (4%) p53(+/-) mice and one of 10 (10%) p53(-/-) mice who prenatally exposed to ENU developed brain tumors. Mice #400 and #505, both of whom are p53(+/-), developed brain tumor (possibly schwannoma) when they are about 30 weeks old. Mice #537(p53[-/-]) and #370 (p53[+/-]) developed gliomas at about 10 weeks old. We should need to increase the incidence of brain tumor induction.
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