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1999 Fiscal Year Final Research Report Summary

The mechanism of joint destruction in osteoarthritis and rheumatoid arthritis.

Research Project

Project/Area Number 09671522
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionJIKEI UNIVERSITY

Principal Investigator

FUJII Katsuyuki  Jikei University School of Medicine, Department of Orthopaedic Surgery, Professor, 医学部, 教授 (10112856)

Co-Investigator(Kenkyū-buntansha) MARUMO Keishi  Jikei University School of Medicine, Department of Orthopaedic Surgery, Lecturer, 医学部, 講師 (70199925)
SAI Shigaku  Jikei University School of Medicine, Department of Orthopaedic Surgery, Associate Professor, 医学部, 助教授 (80183359)
Project Period (FY) 1997 – 1999
KeywordsRheumatoid arthritis / Articular cartilage / Subchondral bone / in situ hybridization / c-fos
Research Abstract

Rheumatoid arthritis (RA) is an enigmatic and incurable disease. Although RA is considered to be an autoimmune disease, its aetiology remains unknown. Therefore, RA presents both diagnostic and therapeutic difficulties to the physician. Here we show strong evidence that RA does not primarily involve the synovial membrane as previously believed, which may allow for the development of a specific treatment for the disease in the future.
It is generally accepted that RA is a chronic inflammatory disease of synovium. The first events in the development of articular damage is the proliferation of synovial cells together with inflammation and vascular neoformation in stroma of synovial tissue. As the disease progresses, the proliferating synovial tissue extends over the articular cartilage and erodes from the joint surface down to and including the subchondral bone. Eventually, small and large joints of patients are destroyed, deformed and ankylosed.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] 藤井克之 他: "慢性関節リウマチならびに変形性関節症の軟骨破壊機構に関する研究"厚生省長期慢性疾患総合研究事業 リウマチ病態解明研究班平成8年度研究報告書. (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤井克之 他: "慢性関節リウマチにおける関節破壊機構について-RA患者ならびに病態モデルに対する検討-"厚生省長期慢性疾患総合研究事業 リウマチ病態解明研究班平成9年度研究報告書. (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤井克之 他: "慢性関節リウマチの骨・関節破壊機序の解明による新治療法開発に関する研究"厚生省長期慢性疾患総合研究事業 リウマチ病態解明研究班平成10年度研究報告書. 20 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujii K, et al,: "Rheumafoid arthritis : A synovial disease?"Ann Rheum Dis. 58. 727-730 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤井克之: "AP-1ヌクレオチドによる慢性関節リウマチにおける骨・軟骨破壊の抑制に関する研究-ラットコラーゲン関節炎を用いた検討-"厚生省感覚器障害及び免疫・アレルギー等研究事業 免疫・アレルギー部門平成11年度研究報告書. 158 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujii K. et al.: "Mansei-Kansetsu riumati narabini hennkeisei kansetsusho no nankotsu hakaikiko ni kansuru kenkyu."Koseisho choki mansei shikkan sogo kenkyu jigyo riumati byotai kaimei kenkyuhan heisei 8 nendo kenkyu houkokusho. (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujii K. et al.: "Mansei-Kansetsu riumati niokeru kansetu hakai kikou ni tsuite-RA kana narabi ni byotai moderu ni taisuru kentou-."Koseisho choki mansei shikkan sogo kenkyu jigyo riumati byotai kaimei kenkyuhan heisei 9 nendo kenkyu houkokusho. (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujii K. et al.: "Mansei-Kansetsu riumati no kotsukansetsu hakai kikou kijo no kaimei ni yoru shinchiryouhou kihatsu ni kansuru kenkyu."Koseisho choki mansei shikkan sogo kenkyu jigyo riumati byotai kaimei kenkyuhan heisei 10 nendo kenkyu houkokusho. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujii K. et al.: "Rhumatoid arthritis : A synovial disease?"Ann Rhum. 58. 727-730 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujii K. et al.: "AP-1 nukureochido ni yoru mansei kansetsu riumati ni okeru kotsu-nankotsu hakai no yokusei ni kansuru kenkyu- rat kora-gen kansetsuen wo mochiita kenkyu-."Koseisho kankakuki shogai oyobi meneki-arerugi nado kenkyu jigyo meneki-arerugi bumon heisei 11nendo kenkyu houkokusho. (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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