1998 Fiscal Year Final Research Report Summary
Physio-pharmacological effects of intravenous anesthetic agent ; Propofol on respiratory depression
| Project/Area Number |
09671547
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Toyama Medical & Pharmaceutical University |
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Principal Investigator |
MASUDA Akira Toyama Medical and Pharmaceutical University, Department of Anesthesiology, Associate Professor, 医学部, 助教授 (30126552)
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| Co-Investigator(Kenkyū-buntansha) |
HAJI Akira Toyama Medical and Pharmaceutical University, Department of Pharmacology, Associ, 医学部, 助教授 (50228433)
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| Project Period (FY) |
1997 – 1998
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| Keywords | Respiration / Respiratory depression / Human volunteer / Uric acid / Propofol / Thiamylal / Sevoflurane / Swallowing reflex / Respiratory control |
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| Research Abstract |
In the first year, we compared the effect of propofol with that of sevoflurane anesthesia on uric acid (UA) excretion in ASA physical status I and II patients with normal renal function. A propofol group (n=11) received propofol-nitrous oxide-fentanyl after induction of anesthesia by propofol while a sevoflurane group (n= 12) received sevoflurane-nitrous oxide-fentanyl after induction of anesthesia by thiamylal. UA, creatinine (Cr), and urea nitrogen concentrations in serum and urine were measured before induction of anesthesia, 1, 2, and 3h after induction, and at 1 postoperative day. N-acety1-beta-D-glucosaminidase, beta_2-microglobulin concentrations and pH in urine were also examined. Plasma clearance of UA (CUA) and Cr (CCr) were calculated. The hourly concentration and excretion of urine UA were significantly higher than those of the sevoflurane. Significant correlations were noted between the hourly urine volume and UA concentration. The CUA of the propofol group was significantly higher than that of the sevoflurane group. There were no significant differences in other renal variables between the two groups. This study demonstrated that the UA excretion increased during propofol anesthesia, while it remained stable during sevoflurane anesthesia.
In the second year, we investigated the effects of propofol and thiamylal on swallowing reflex in 26 adult volunteers. They were sedated with either propofol (Group P : n=16) or thiamylal (Group T : n=10). Swallowing was induced by bolus injections of distilled water (0.25, 0.5, 0.75 and 1.0 mL) into the pharynx via an epidural catheter. The responses to injections of water were analyzed in terms of the number of swallows elicited and the latency of response. The latency was prolonged and the number of swallows were decreased in Group F, but not in Group T.These results suggest that propofol depresses swallowing reflex greater than that of thiamylal.
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