1998 Fiscal Year Final Research Report Summary
The effect of intraoperative mild hypothermia on the development of perioperative cardiac ischemia
| Project/Area Number |
09671582
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Anesthesiology/Resuscitation studies
|
|---|
| Research Institution | Nara Medical University |
|---|
Principal Investigator |
FURUYA Hitoshi Nara Medical University Professor, 医学部, 教授 (70183598)
|
|---|
| Project Period (FY) |
1997 – 1998
|
| Keywords | Mild Hypothermia / Complication / Cardiac ischemia / Intraoperative Management / Anesthesia |
|---|
| Research Abstract |
We evaluated the risk of perioperative cardiac ischemia associated with mild hypothermia as adjunct management for neurosurgical procedures. Forty-seven elective neurosurgical patients were randomly assigned to either hypothermic group (H, n=24) or normothermic one (N, n=23). Patients in group H were cooled to and maintained at 34.5 degrees C (tympanic membrane temperature) and rewarmed after main neurosurgical manipulation, while ones in group N were kept in normothermic state. Cardiac ischemia was diagnosed with Holter electrocardiogram monitored for 24 hours after admission to the operating room.
No differences were observed in demographic data including age, gender, weight, height, rate of having cardiac disease, anesthesia methods, and contents of surgery. Temperature was significantly lower in group H than N both at the lowest point(34.6*O.5 vs 35.9*0.6, means*SD) and at the conclusion of anesthesia (35.9*0.9 vs 36.5*0.5). Electrocardiographic ST segmental depression was observed in 3 (group H) and 5 cases (group N), and postoperative shivering occurred in 3 (group H) and 2 cases (group N), respectively. Those incidences were not statistically significant (chi-square test, p was set at 0.05). We concluded that intraoperative mild hypothermia might not increase the risk of perioperative cardiac ischemia in patients underwent neurosurgical procedures.
|
