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1998 Fiscal Year Final Research Report Summary

Celluar mechanism of fibrosis in the obstructed kidney

Research Project

Project/Area Number 09671601
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionTOHOKU University

Principal Investigator

FUKUZAKI Atsushi  Tohoku Univ., Hospital, Lecturer, 医学部・附属病院, 講師 (70133957)

Co-Investigator(Kenkyū-buntansha) KANETO Hiroyuki  Tohoku Univ, Sch of Med, Research Associate, 医学部, 助手 (00224626)
Project Period (FY) 1997 – 1998
Keywordskidney / fibrosis / obstruction / siqnal transduction
Research Abstract

Renal interstitial fibrosis is a common consequence of long-standing obstructive uropathy. Fibrosis likely develops due to an imbalance between extra cellular matrix synthesis and deposition and matrix degradation. The protease plasmin can degrade avariety of extra cellular matrix molecules. Plasmin generation from plasminogen is highly regulated by the interaction of plasminogen activator inhibitor-1 (PAL-i). It has recently been shown that angiotensin II acts both directly and through induction of TGF-beta to alter the PAI-1/plasmin system. We investigated PAL-i activity in the obstructed kidney and demonstrated increased PAL-i expression in the unilaterally obstructed rat kidney. The result indicates that angiotensin II dependent inhibition of plasmin system by increased PAI-1 activity may play an important role intubulointerstitial fibrosis in the obstructed kidney. In addition, we demonstrated angiotensin II dependent cytokine expression and inflammatory cell infiltration contribute to the tubulointerstitial fibrosis and progression of the disease in the human obstructed kidneys. Furthermore, we clarified persistent activation of renin-angiotensinsystem (RAS) in the patient with chronic ureteral obstruction. These results indicate that inhibition of RAS may have a key role to protect obstructed kidneys from progression of the disease.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 折笠精一: "萎縮性腎盂腎炎" 日本臨床. 別冊. 229-234 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 折笠精一: "閉塞性腎盂腎炎" 日本臨床. 別冊. 272-274 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 折笠精一: "閉塞性腎症" 日本臨床. 別冊. 688-690 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 福崎 篤: "閉塞性尿路疾患、水腎症" 腎と透析. 47. 印刷中 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shigenori Ikeda: "Role of protein kinase C in cisplatin Nephrotoxicity" International Journal of Urology. 印刷中 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 福崎 篤: "閉塞性腎症による尿細管、間質性腎障害" 日本内科学会雑誌. 88. 印刷中 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 折笠精一: "小児泌尿器科学書" 金原出版, 483 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Orikasa S,Fukuzaki A: "Atrophic pyelonephritis." Nihon Rinsho, Suppl.16. 229-234 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Orikasa S,Fukuzaki A: "Obstructive pyelonephritis" Nihon Rinsho, Suppl.16. 272-274 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Orikasa S,Fukuzaki A: "Obstructive nephropathy." Nihon Rinsho, Suppl.17. 688-690 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Orikasa S,Fukuzaki A: "Renal physiology and function." Text book of Pediatric Urology, Kanehara Shuppan, Tokyo. 117-123 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukuzaki A: "Hydronephrosis" Jin to Toseki. 47 (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ikeda S,Fukuzaki A,Kaneto H,Ishidoya S,Orikasa S: "Role of protein kinase C in cisplatin nephrotoxicity." Int J Urol. 6 (in press). 245-250 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukuzaki A: "Tubulointerstitiak fibrosis in obstructive nephropathy" Nihon Naika Gakkai Zasshi. 88 (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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