1999 Fiscal Year Final Research Report Summary
On the cause for the urinary incontinence derived from overactive detrusor muscles : Analysis by morphological changes in cell junctions
| Project/Area Number |
09671605
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Chiba University |
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Principal Investigator |
TOYAMA Yoshiro CHIBA UNIVERSITY SCHOOL OF MEDICINE, LECTURER, 医学部, 講師 (70009637)
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| Co-Investigator(Kenkyū-buntansha) |
YASUDA Kousaku DOKKYO MEDICAL SCHOOL, KOSHIGAYA HOSPITAL, PROFESSOR, 越谷病院, 教授 (70009710)
YAMANISHI Tomonori CHIBA UNIVERSITY SCHOOL OF MEDICINE, LECTURER, 医学部, 講師 (90220425)
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| Project Period (FY) |
1997 – 1999
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| Keywords | LOWER URINARY TRACT / URINARY BLADDER / DETRUSOR MUSCLE / URINARY TRACT SYMPTOMS / AGING / ULTRASTRUCTURE / GAP JUNCTION |
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| Research Abstract |
One of the causes for the urinary incontinence in aged man is considered to be overactivity of the detrusor muscles. The function of detrusor muscles of 32 aged patients with bladder neck constracture were analysed by a video-urodynamics method using a microtip-transducer. The effects of terazosin, an adrenalin receptor α, on the detrusor muscle were also examined. Biopsy samples from patients with baldder neck constracture were also examined by electron microscopy. Distribution pattern of slow muscle fibers and fast muscle fibers and the ratio of slow to fast muscle fibers were examined by a histochemical method.
The results showed that bladder neck constracture in most patients was organic, and the adrenalin receptor α was dominant to the adrenalin receptor β in the detrusor muscles in the patients with bladder neck constracture. Electron micrographs showed that the gap junctions in the detrusor muscles in the patients with lower urinary tract symptoms were hypotrophic, indicating that overactivity of the urinary bladder with lower urinary tract symptoms was derived from hypoplastic gap junctions between muscle cells in the detrusor. The fast and slow muscle fibers were mixed randomly in the detrusor muscles of the dog. A specific distribution pattern with aging was not found.
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