1998 Fiscal Year Final Research Report Summary
Correlation of clinical data and polymorphism for αィイD21aィエD2-adrenoceptor subtypes gene in Japanese patients with benign prostatic hypertrophy
| Project/Area Number |
09671608
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | The UNIVERSITY OF TOKYO |
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Principal Investigator |
MORIYAMA Nobuo The University of Tokyo, Urology, Assistant Professor, 医学部・附属病院, 講師 (80143501)
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| Co-Investigator(Kenkyū-buntansha) |
KAMEYAMA Shuji The University of Tokyo, Urology, Assistant Professor, 医学部・附属病院, 講師 (90186015)
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| Project Period (FY) |
1997 – 1998
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| Keywords | Human prostate / Benign prostatic hypertrophy / αィイD21ィエD2-adrenegic receptor |
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| Research Abstract |
One of αィイD21aィエD2-adrenoceptor subtypes ,αィイD21aィエD2-adrenoceptor is implicated in the pathophysiology of benign prostatic hypertrophy (BPH). We examined polymorphism of the human ala-AR gene (Arg492 to Cys) in 222 BPH patients. There was no significant association of αィイD21aィエD2-adrenoceptor polymorphism with clinical (onset and degree of symptoms, size of BPH and response to αィイD21aィエD2-adrenoceptor blocker) and laboratory data (cholesterol and other lipid data, prostatic specific antigen, testosterone level) of the patient with BPH ; however, the allele frequency in Japan was markedly different from US populations. The results did support the idea that BPH is associated with alterations in αィイD21aィエD2-adrenoceptor gene.
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