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1999 Fiscal Year Final Research Report Summary

Basic Research for Establishment of Ideal Orthotopic Neobladders. -Investigation using a computer simulating model-

Research Project

Project/Area Number 09671627
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionKobe University School of Medicine

Principal Investigator

OKADA Hiroshi  Kobe Univ. Hospital, Department of Urology, Lecturer, 附属病院, 講師 (00177057)

Co-Investigator(Kenkyū-buntansha) KAMIDONO Sadao  Kobe Univ. School of Medicine, Department of Urology, Professor, 医学部, 教授 (30030935)
FUJISAWA Masato  Kobe Univ. Hospital, Department of Urology, Research Assistant, 附属病院, 助手 (30243314)
Project Period (FY) 1997 – 1999
Keywordsorthotopic neobladder / bladder cancer / voiding function / incontinence / hypercontinence / bone density / calcium metabolism / OOL
Research Abstract

1.Voiding functions of several types of orthotopic neobladders
We investigated voiding functions of 30 men who underwent orthotopic neobladder replacement after radical cystectomy due to invasive bladder cancers. Colonic Neobladder (CN) was created in 7 patients, ileocolic neobladder (ICN) in 10 patients, ileal neobladder (IN) in 10 patients, and sigmoid colonic neobladder (SCN) in 3 patients, and all were followed at least 5 years after surgery. Daytime continence was obtained in more than 90% in any type of neobladder, however, nocturnal continence was achieved better in patients with IN than other neobladders using colonic segments. This phenomenon is better compliance of the neobladder using ileal segment than those using colonic segments.
2.Voiding functions in female patients with orthotopic neobladder
Indication of orthotopic neobladder replacement was expanded to the female patients. We analyzed the voiding functions of female patients who underwent orthotopic neobladder replacement with CN(2), ICN(2), and IN(4). Continence was achieved satisfactorily, however, those with IN became hypercontinent and required clean intermittent catheterization. Thus for female patients neobladder using colonic segments is rationale.
3.Calcium metabolism in the patients with orthotopic neobladders
Calcium metabolism and bone mineral density were measured in patients with orthotopic neobladders ; CN(2), ICN(8), and SCN(23). Patients with orthotopic neobladder were suffered from metabolic acidosis and demineralization of the bones to various extent. This phenomenon, if very slight, may become serious drawback of the orthotopic neobladder replacement. Thus we propose to start investigation to utilize tissue engineering technology to recreate true bladders.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] H. OKADA, A. GOTOH, et al.: "Pitfalls of measuring residual urine volume in orthotopic neobladder"British Journal of Urology. 80. 567-569 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H. OKADA, Y. YAMADA, et al.: "ADENOMA IN THE ORTHOTOPIC NEOBLADDER"THE JOURNAL OF UROLOY. 151. 1358 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H. OKADA, N. YAMANAKA, et al.: "Construction and Voiding Functions of Three Type of Orthotopic Neobladders Using Colonic Segments : The Kobe University Experience"Int. Journal of Urology. 5. 22-29 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H. SHIMOGAKI, H. OKADA, et al.: "LONG-TERM EXPERIENCE WITH ORTHOTOPIC RECONSTRUCTIONOF THE LOWER URINARY TRACT IN WOMEN"THE JOURNAL OF UROLOY. 161. 573-577 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岡田 弘,原 勲 et.al: "膀胱全摘後に自然排尿型新膀胱(orthotopic neobladder)を造設した患者の排尿機能と勃起能"泌尿器外科. 12. 435-440 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M. Fujisawa, H. Okada, et al.: "CHANGES IN CALCIUM METABOLISM AND BONE DEMINERALIZATION AFTER ORTHOTOPIC INTESTINAL NEOBLADDER CREACTION"THE JOURNAL OF UROLOY. 163 (印刷中). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Okada, A.Gotoh, M.Fujisawa, I.Hara, K.Gohji, S.Arakawa, S.Kamidono: "Pitfalls of measuring residual urine volume in orthotopic neobladders"British Journal of Urology. vol.80. 567-569 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroshi Okada, Yuji Yamada, Ichiro Nakamura, Masato Fujisawa, Isao Hara, Kazuo Gohji, Soichi Arakawa, Sadao Kamidono: "Adenoma in the orthotopic neobladder"Journal of Urology. vol.157. 1358 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroshi Okada, Nozomu Yamanaka, Hitoshi Oh-Oka, Akinobu Gotoh, Ichiro Nakamura, Isao Hara, Masato Fujisawa, Kazuo Gohji, Soichi Arakawa, Sadao Kamidono: "Construction and voiding functions of three types of orthotopic neobladders using colonic segments : the Kobe University experience"International Journal of Urology. vol.5. 22-29 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masato Fujisawa, Ichiro Nakamura, Akinobu Gotoh, Nozomu Yamanaka, Isao Hara, Hiroshi Okada, Soichi Arakawa, Sadao Kamidono: "Changes in calcium metabolism and bone demineralization after orthotopic intestinal neobladder creation"Journal of Urology. vol.163(in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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