1998 Fiscal Year Final Research Report Summary
The basic research on specific bone metastasis of prostatic cancer from the viewpoint of the bone side factor of sex hormone
| Project/Area Number |
09671639
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Nagoya City University |
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Principal Investigator |
KAWAI Noriyasu Nagoya City University Medical School, Research Associate., 医学部, 助手 (20254279)
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| Co-Investigator(Kenkyū-buntansha) |
山田 泰之 名古屋市立大学, 医学部, 助手 (60264735)
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| Project Period (FY) |
1997 – 1998
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| Keywords | PROSTATIC CANCER / BONE METASTASIS / BONE MARROW / HEMOGLOBIN / FACS |
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| Research Abstract |
OBJECTIVES: The prostatic cancer is the cancer, which metastasize to bone specifically. However, the mechanism of specific bone metastasis of prostatic cancer is unclear. When the organ specific metastasis is considered, the cancer cell often has the factor for organ specific metastasis. We studied the factor in the organ side in specific bone metastasis of prostataic cancer.
METHODS: The bone marrow supernatant of rabbit was extracted, and it separated by using the high performance liquid chromatogaphy. For each fractionation, the degree of the adhesion of PC-3 was examined. On the fractionation with the biological activity, molecular weight and amino acid sequence were examined.
RESULTS: The hemoglobin might have 80% homology on the fractionation with the biological activity. Human colon cancer cell as a representative of the organ nonspecific metastasis and human leukemia cell as a representative of non-solid tumor were examined the degree of the adhesion of the human hemoglobin. In these cell lines, the adhesion of human hemoglobin to PC-3 was shown to be strongest of the three.
COCLUSIONS: The assertion cannot be done with that the hemoglobin is concerned in specific bone metastasis of the prostatic cancer. Some substance in bone marrow seems to be concerned in the first step of adhesion to bone marrow cavity in specific bone metastasis of the prostatic cancer which have some amino acid sequence or some tertiary structure which are similar to the position of the hemoglobin to adhere to PC-3.
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