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1999 Fiscal Year Final Research Report Summary

Effect of Interferon-α treatment for HCV-positive renal transplant recipients and hempdialysed patients.

Research Project

Project/Area Number 09671652
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Urology
Research InstitutionDepartment of Urology, Kidney Center, Tokyo Women's Medical University

Principal Investigator

TANABE Kazunari  Tokyo Women's Medical University, Lecturer, 医学部, 講師 (80188359)

Co-Investigator(Kenkyū-buntansha) YAGISAWA Takashi  Tokyo Women's Medical University, Lecturer, 医学部, 講師 (80167692)
TOKUMOTO Tadahiko  Tokyo Women's Medical University, Assistant, 医学部, 助手 (30246540)
TOMA Hiroshi  Tokyo Women's Medical University, Professor, 医学部, 教授 (90075549)
HAYASHI Naoaki  Tokyo Women's Medical University, Professor, 医学部, 教授 (10075286)
HASHIMOTO Etuko  Tokyo Women's Medical University, Lecturer, 医学部, 講師 (40130273)
Project Period (FY) 1997 – 1999
KeywordsHCV / renal transplantation / Interferon-α
Research Abstract

(Aim & method)
Natural typer interferon α(INFα)was administered to HCV positive hemodialysis and transplant patients in order to eliminate HCV.Hemodialysed patients were received INFα500×10^4U for 14 days and followed by 500×10^6U, 3 times/week, for 6 months. Renal transplant recipients with HCV were administered INFα1000×10^6U for 14days and followed by 1000×10^6U, 3 times/week for 6 months.
(Results)
12 hemodialysed patients an 10 renal transplant recipients were enrolled in this study. All 22 patients showed at least partial response with normalization of transaminase and negative HCV-RNA.11 patients showed complete response without returning HCV-RNA positive after 6 months of conclusion of INFαtreatment.
(Conclusion)
INFαtreatment for the hemodialyzed patients and renal transplant recipients with HCV was highly effective to eliminate HCV.

  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] T.Tokumoto: "Effect of interferon(INF-alpha)for prevention of hepatitis C transmission from a seropositive donor to a seronegative Recipient in renal transplantation."Transplant Proc.. 28. 1503-1504 (1996)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田邉一成: "腎移植と肝疾患"腎と透析. 42. 659-662 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Tanabe: "LONG-TERM RENAL FUNCTION IN NON-HEAT-BEATING DONOR KIDNEY TRANSPLANTATION"Transplantation. 66. 1708-1713 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Tanabe: "Infectious Complications in ABO-Incompatible Living Donor Kidney Transplantation : A Single Center Experience"Transplantation Proceedings. 30. 3130-3132 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Tokumoto: "Effect of interferon-alpha teratment in renal transplant recipients with chronic hepatitis C,"Transplant Proc.. 30. 3270-3272 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Tanabe: "Impact of OKT3 Treatment for Steroid Resistant Rejection of Renal Allgragts : The Long-Term"Transplant Proc.. 31. 2870-2871 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Tanabe: "Long-Term Results in Mizoribine-Treated Renal Transplant Recipients : A Prospective, Randomized Trial of Mizoribine and Azathioprine Under Cyclosporine-Based Immunosuppression"Transplant Proc.. 31. 2877-2879 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Toma: "Pregnacy in women receiving renal dialysis or transplantation in Japan : a nation wide survey"Nephrol Dial Transplantation. 14. 1511-1516 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田邉一成: "移植腎を長期に生着させるためには〜合併症とその対策-肝障害"腎と透析. 47. 511-518 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Tokumoto: "Kidney transplantation from donor with HCV antibody positive and HCV-RNA negative"Transplant Proc.. (in printing). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Tokumoto: "Effect of interferon(INF-alpha) for prevention of hepatitis C transmission from a seropositive donor to a seronegative Recipient in renal transplantation."Transplant Proc.. 28. 1503-1504 (1996)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Tanabe: "Renal transplantation and liver disease"Kidney and Dialysis. 42. 659-662 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Tanabe: "LONG-TERM RENAL FUNCTION IN NON-HEAT-BEATING DONOR KIDNEY TRANSPLANTATION."Transplantation. 66. 1708-1713(12) (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Tanabe: "Infectious Complications in ABO-Incompatible Living Donor Kidney Transplantation : A Single Center Experience."Transplantation Proceedings. 30. 3130-3132 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Tokumoto: "Effect of interferon-alpha treatment in renal transplant recipients with chronic hepatitis C"Transplant Proc.. 30. 3270-3272 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Tanabe: "Impact of OKT3 Treatment for Steroid Resistant Rejection of Renal Allgrafts : The Long-Term Outcome at a Single Center."Transplant Proc.. 31. 2870-2871 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Tanabe: "Long-Term Results in Mizoribine-Treated Renal Transplant Recipients : A Prospective, Randomized Trial of Mizoribine and Azathioprine Under Cyclosporine-Based Immunosuppression."Transplant Proc.. 31. 2877-2879 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Toma: "Pregnacy in women receiving renal dialysis or transplantation in Japan : a nation wide survey."Nephrol Dial Transplantation. 14. 1511-1516 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Tanabe: "To keep renal allgraft for long -term -liver dyofution-"Kidney and Dialysis. 47. 511-518 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Tokumoto: "Kidney transplantation from donor with HCV antibody positive and HCV-RNA negative."Transplant Proc.. (in printing). (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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