1998 Fiscal Year Final Research Report Summary
Analysis of Growth Retarded Fetus with Molecular Genetics -Correlation with Genomic Imprinting or Uniparental Disomy-
| Project/Area Number |
09671697
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Nagasaki University |
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Principal Investigator |
MASUZAKI Hideaki Nagasaki University, School of Medicine, University Hospital, Lecturer, 医学部附属病院, 講師 (00173740)
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| Co-Investigator(Kenkyū-buntansha) |
JINNO Yoshihiro Nagasaki University, School of Medicine, Associate Professor, 医学部, 助教授 (20179097)
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| Project Period (FY) |
1997 – 1998
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| Keywords | IUGR / CPM / UPD / IGF2 |
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| Research Abstract |
1) Chromosomal analysis of the amniotic fluid and placenta was performed on forty cases with growth retarded fetus. Confined placental mosaicism(CPM) was found. in four cases(lO%). Placental karyotypes of these four cases were, l)mos 46, XY /50, XY, +2, +7, +15, +20, 2) mos 46, XY/48, XY, +7, +13, 3) mos 46, XY/47, XY, +13 and 4)mos 46, XY/47, XY, +2, respectively.
2) Though molecular analysis was performed in one case with fetus suspected Russell-Silver syndrome, uniparental disomy was not existed.
3) No abnormality was found about IGF2 gene in a placenta associated with fetal growth retardation.
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