2000 Fiscal Year Final Research Report Summary
Calcium metabolism in normal pregnancy and pregnancy induced hypertension
| Project/Area Number |
09671698
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | Ehime University |
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Principal Investigator |
ITO Masaharu Ehime University, Faculty of Medicine, Professor, 医学部, 教授 (10136731)
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| Project Period (FY) |
1997 – 2000
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| Keywords | pregnancy induced hypertension / uterine artery / calcium |
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| Research Abstract |
Because pregnancy induced hypertension improves rapidly after delivery, it is thought to be caused by a disturbance in uteroplacental circulation. Injury to endothelial cells caused by serum may have a role in the onset of pregnancy induced hypertension. We investigated the relation between serum samples from women with pregnancy induced hypertension and endothelial cell Cas^<++>. The Ca^<++> was induced by serum samples from women with pregnancy induced hypertension. We believe that some factors in serum samples from women with pregnancy induced hypertension could modulate periodic secretion of nitric oxide by endothelial cells. Then, we investigated the basic biological significance of diastolic notches in uterine artery flow velocity waveforms. Five pregnant ewe at 16-17 weeks of pregnancy were used in the study. Micro-beads (Gelfoam) were stepwisely administered into the uterine artery and changes in uterine circulation were assessed by Doppler velocimetry. Pulsatility index linear
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ly correlated with uterine vascular resistance, giving a high correlation coefficient. The mean values of uterine vascular resistance and PI when diastolic notches appeared were 2.13±and 450±92 mmHg・min・L^<-1>, respectively. It could be concluded that the elevation of PI and presence of diastolic notches in the uterine arteries are indicators of high uterine vascular resistance and impaired uterine circulation. Furthermore, we investigated the urinary levels of orotic acid in normal pregnancy and in pregnancy-induced hypertension. Such levels were measured using high-performance liquid chromatography with column-switching. Normal pregnant individually showed a significant elevation at 20 and 30 weeks of gestation as compared with those in the first trimester. A high consumption of arginine in nitric oxide production during normal pregnancy may cause a physiological elevation of urinary orotic acid. The absence of an elevation in pregnancy-induced hypertension may be associated with a decrease in nitric oxide production. Less
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