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1998 Fiscal Year Final Research Report Summary

Evaluation of neovascularization and microcirculation in the corpus luteum

Research Project

Project/Area Number 09671713
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Obstetrics and gynecology
Research InstitutionKeio University

Principal Investigator

MIYAZAKI Toyohiko  Keio University, School of Medicine, assistant professor, 医学部, 講師 (20174162)

Project Period (FY) 1997 – 1998
Keywordscorpus luteum / microcirculation / blood flow
Research Abstract

The objective of this study is to determine the role of microcirculation and free radicals in the control of ovarian corpus luteum (CL) function. To evaluate neovascularization in the CL, power and color Doppler imaging were used. The blood supply to the ovary bearing CL is thought to increase during luteal phase, resulting in the provision of low-density lipoprotein to luteal cells for progesterone (P) production. The increase in blood flow to the CL suggests an increase in the vascular bed of developing CL and the existence of discrepancy between the period of maximum P concentration and the period of maximum blood flow to the CL reflect the fact that an increase in circulating hormone may lag behind a structural increase in vasculature. The intravital microscopy was used to observe the microvasculature in the CL of pseudopregnant rat. The characteristics of microvasculature of the CL in early- and late-pseudopregnancy consisted of the low vascular density and the formation of shunt vessels. During pseudopregnancy, production of free radicals was observed in the extravascular area in the CL.Administration of prostaglandin F_<2alpha> (PGF_<2alpha>) induced the production of free radicals in the CL within 15 minutes. Although immediate changes of microcirculation within the CL were not observed after PGF_<2alpha> administration, the destruction of vascularity and the shunt vessels within CL were observed 48 hours after PGF_<2alpha> administration. This may suggest that PGF_<2alpha>-induced free radicals affect the structural changes in the vasculature of the CL.

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Miyazaki T: "Power and colour Doppler ultrasonography for the evaluation of the vasculature of the human corpus luteum." Hum Reprod. 13. 2836-2841 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akaboshi K: "The effects of gonadotropin-releasing hormone agonist on androstenedione production and follicular development during controlled ovarian hyperstimulation." J Assist Reprod Genet. 15. 477-483 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamauchi J: "Effects of nitric oxide on ovulation and ovarian steroidogenesis and prostaglandin production in the rabbit." Endocrinology. 138. 3630-3637 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮崎豊彦: "NOと排卵" HORMONE FRONTIER IN GYNECOLOGY. 6. 31-37 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮崎豊彦: "血流と着床環境" 産婦人科の実際. 48. 71-76 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 宮崎豊彦: "黄体機能調節機構における微小循環とフリーラジカルの役割" 日本産科婦人科学会雑誌. 50. 511-518 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Miyazaki T: "Power and color Doppler ultrasonography for the evaluation of the vasculature of the human corpus luteum." Hum Reprod. 13. 2836-2841 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akaboshi K: "The effects of gonadotropin-releasing hormone agonist on androstenedione production and follicular development during controlled ovarian hyperstimulation." J Assist Reprod Genet. 15. 477-483 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Miyazaki T: "The role of microcirculation and free radicals in the regulatory system of corpus luteum function." Acta Obstet Gynaec Jpn. 50. 511-518 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamauchi J: "Effects of nitric oxide on ovulation and ovarian steroidoqenesis and prostaglandin production in the rabbit." Endocrinology. 138. 3630-3637 (1997)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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