1998 Fiscal Year Final Research Report Summary
Effect of calcitonin gene-related peptide (CGRP) on testicular descent in grnitofemoral nerve divided rats.
| Project/Area Number |
09671832
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
小児外科
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
SHONO Takeshi Kyushu University, Pediatric Surgery, Senior Registra, 医学部, 講師 (30235717)
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| Co-Investigator(Kenkyū-buntansha) |
SUITA Sachiyo Kyushu University, Pediatric Surgery, Professor, 医学部, 教授 (30038856)
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| Project Period (FY) |
1997 – 1998
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| Keywords | cryptorchidism / rat / calcitonin gene-related peptide / genitofemoral nerve |
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| Research Abstract |
Testicular descent was inhibited in rats which were performed the division of genitofemoral nerve (GEN) n neonatal period. At 60-90 days old, cryptorchidism was occurred in about 76% in rats which were performed the division of genitofemoral nerve in neonatal period, However, the occurrence of cryptorchidism was significantly decreased in 30-days-old rats which were first performed neonatal GFN division and 20mu gof CGRP was injected subcutaneously in hemiscrotum on operated side from 3to 14 days old. CGRP has been known one of neuropeptide and is released from the terminal of the GFN to mediated the inguinoscrotal testicular descent.
These results suggested that the CGRP might be important peptide to induce normal testicular descent and might be used as effective regimen for the cryptorchidism.
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