1998 Fiscal Year Final Research Report Summary
Comparison between concentration of I type collagen C-terminal telopeptide (ICTP) in the synovial fluid and semi-quantified ^<99m>Tc-MDP accumulation of the temporpmandibular joint in the tempromandibular joint disorders (TMD).
| Project/Area Number |
09672072
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | NIPPON DENTAL UNIVERSITY |
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Principal Investigator |
SATO Akira Department of Oral & Maxillofacial Surgery II,School of Dentistry at NIIGATA,NIPPON DENTAL UNIVERSITY Instructor, 新潟歯学部, 助手 (50267267)
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| Co-Investigator(Kenkyū-buntansha) |
TOYAMA Michio Department of Oral & maxillofacial Radiology, School of Dentistry at NIIGATA,NIP, 新潟歯学部, 助手 (00217564)
TSUCHIMOCHI Makoto Department of Oral & maxillofacial Radiology, School of Dentistry at NIIGATA,NIP, 新潟歯学部, 教授 (20095186)
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| Project Period (FY) |
1997 – 1998
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| Keywords | tempromandibular joint disorders / arthrocentesis in temporomandibular joint / pumping manipulation / bone scintigrapy / ICTP / cytokine |
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| Research Abstract |
We investigated the relationship between clinical outcome of arthrocentesis in temporomandibular joint >sorders and the concentration of the bone metabolic marker, ICTP (type I collagen C-terminal telopeptide), in the synovial fluid. The purpose of this study is to evaluate the predictability of ICTP for outcome of arthrocentesis. Materials and Methods : Twenty-four patients with TMJ disorders (mean age ; 42.1*20.1 years, range in age from 14 to 86) undergoing arthrocentesis and sodium hyaluronate injection of TMJs were enrolled in this study between October 1997 and August 1998.Sixteen TMJs of 14 patients were clinically diagnosed internal derangements (ID) and 10 TMJs of 10 patients were diagnosed osteoarthrosis (QA). Synovial fluid was obtain from 26 joints at the time of arthrocentesis.The concentration of ICTP was measured using ICTP radio immunoassay. Result : The mean preoperative maximum incisal opening (MIG) was 33.5 11.1 mm. About one month after the procedure, MIG increased (43.0 *6.2mm), and pain disappeared or decreased in all patients. There was no significant difference in ICTP concentration of the synovial fluid between patients with GA (2.6*2.8 ng/ml) and ID (2.42.2 ng/ml). However, the mean concentration of ICTP from poor responders (MIO<40.Omm at the time about one month after the procedure) was higher (3.8*3.3 ng/ml) than those (2.2*2.1 ng/ml) of good responders (MIO*4O.O mm). Conclusion : The results of this study indicate that ICTP concentration may be an efficient predictor for the outcome of arthrocentesis.
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