Study on Maternal Environmental Factors for Cleft Lip and/or Palate by Transplanting Fertilized Ova

1999 Fiscal Year Final Research Report Summary

• Project/Area Number: 09672080
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Surgical dentistry
• Research Institution: Aichi-Gakuin University
• Principal Investigator: NATSUME Nagato Aichi-Gakuin University, 2nd Department of Oral & Maxillofac. Surgery, Professor, 歯学部・口腔外科学第二講座, 特殊診療科教授 (90183532)
• Co-Investigator(Kenkyū-buntansha): NIIMI Teruyuki Aichi-Gakuin University, 2nd Department of Oral & Maxillofac. Surgery, Assistant Professor, 歯学部・口腔外科学第二講座, 助手 (60291762) ; KINOSHITA Hiroyuki Aichi-Gakuin University, 2nd Department of Oral & Maxillofac. Surgery, Assistant Professor, 歯学部・口腔外科学第二講座, 助手 ; KAWAI Tsuyoshi Aichi-Gakuin University, Honorary Professor, 歯学部, 名誉教授 (50064788)
• Project Period (FY): 1997 – 1999
• Keywords: Cleft lip / Cleft palate / CL / P-prone mouse / A / J mouse / C57 / BL mouse / plantation of fertilized ova / maternal environmental factor

Research Abstract

1. We carried out screening in 1998 on the incidence of CL/P. Based on those results we made clear if it is possible to reduce the risk of CL/P appearance by transplantation of fertilized ova along with basic treatments.
2. As we evaluated the following assumptions : How much influence does maternal environment have on CL/P ? If it has much influence, what kind of patients can be protected from CL/P by transplantation of fertilized ova ? Is it possible to prevent CL/P appearance only by basic treatments ?
3. We submitted our study to the Journal "PLASTIC AND RECONSTRUCTIVE SURGERY" and how it is in press.
Collaborator : Jun Kuno (Aichi-Gakuin University, 2nd Department of Oral & Maxillofac. Surgery, Assistant Professor)

Research Products

• [Publications] 久野淳: "マウス受精卵移植における口唇,口蓋裂発生に関する実験的研究-口唇,口蓋裂非発生系(C57BL/6系)マウス受精卵の易発生系(A/J系)マウスへの移植-"愛知学院大学歯学会誌. 36(4). 611-616 (1998)
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Jun Kuno, Nagato Natsume, Tsuyoshi Kawai: "Transplantation of Fertilized Ova of CL/P-resistant C57BL/6 Strain Mice to Pseudo-pregnant CL/P-prone A/J Strain Mice"PLASTIC AND RECONSTRUCTIVE SURGERY. (印刷中).
  • Description: 「研究成果報告書概要(和文)」より
• [Publications] Jun Kuno: "Experimental Study on Cleft Lip and/or Palate in Transplantation of Fertilized Ovum Mice, - In the Case of Transplantation of Fertilized Ova of CL/P - Resistant C57BL/6 Strain Mice to Pseudopregnant CL/P-Prone A/J Strain Mice-"The Aichi-Gakuin Journal of Dental Science. 36(4). 611-616 (1998)
  • Description: 「研究成果報告書概要(欧文)」より
• [Publications] Jun Kuno, Nagato Natsume, Tsuyoshi Kawai: "Transplantation of Fertilized Ova of CL/P-Resistant C57BL/6 Strain Mice to Pseudo-Pregnant CL/P-prone A/J Strain Mice"PLASTIC AND RECONSTRUCTIVE SURGERY. in press.
  • Description: 「研究成果報告書概要(欧文)」より