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1999 Fiscal Year Final Research Report Summary

Experimental and Clinical Studies on Dental Caries Provention by a New Mouthrinsing Agent of Quaternary Ammonium Salts

Research Project

Project/Area Number 09672124
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 矯正・小児・社会系歯学
Research InstitutionNippon Dental University

Principal Investigator

NAKAMURA Yasunori  School of Dentistry Lecturer at Niigata, The Nippon Dental University, 新潟歯学部, 講師 (20095201)

Project Period (FY) 1997 – 1999
KeywordsDequalinium chloride / Domiphen bromide / Rinsing agent / Gtase inhibitor / Plaque control / Caries prevention / Rat / Human
Research Abstract

The effects of dequalinium chlorid (DC) and domiphen bromide (DB), a quaternary ammonium salts, on experiment in vitro, experimental dental caries andclinical examination were determined.
1. From the results of experiment in vitro, it is indicated that DC and DB have an inhibitory ability against glucosyltransferases activity of serotype c strain (S. mutans) and serotype g strain (S. sobrinus), and particularly a marked inhibitory effect was observed in DC.
2. From the results of experimental dental caries in rats given DC or DB solution as drinking water, it is indicated that DC and DB have an inhibitory action of caries development by decreasing the number of bacterial cells adhering to the teeth, and particularly a marked inhibitory effect was observed in DC.
3. From the results of clinical examination in humans mouthrinsed with DC or DB solution, it is indicated that DC has significant effect on inhibiting the formation of dental plaque.
From these results, it can be considered that DC and DB inhibited the caries development by decreasing the bacterial cells adhering to teeth and inhibiting the formation of dental plaque. In addition, no toxic effects of DC and DB on rats and humans were observed under the present experimental conditions.
Taking thses resalts into consideration, DC is expected to be useful for prevention of dental caries as mouthrising agents.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 中村康則 他2名: "う蝕病原菌の不溶性グルカン合成に対する第4級アンモニウム塩類の抑制効果"歯科基礎医学会雑誌. 39. 159 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中村康則 他6名: "新しい電解酸化水のS.sobrinus 6715株接種ラットにおけるう蝕抑制効果"歯学. 86. 335-342 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中村康則 他3名: "S.sobrinus 接種ラットにおける第4級アンモニウム塩のう蝕抑制効果"歯科基礎医学会雑誌. 40. 156 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 桑島治博、中村康則 他2名: "S.sobrinus接種ラットにおける塩化デカリニウムのう蝕抑制効果"歯科基礎医学会雑誌. 40. 157 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中村康則 他2名: "う蝕病原菌の非水溶性グルカン合成に対する第4級アンモニウム塩類の抑制効果"歯科基礎医学会雑誌. 40. 648-655 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中村康則 他4名: "Streptococcus sobrinus 6715株接種ラットにおけるアルギン酸ナトリウムのう蝕抑制効果"歯学. 87. 530-536 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yasunori Nakamura et al: "Inhibitory effect of quaternary ammonium salts on glucosyltransferases of cariogenic bacterium"Japanese zjournal of Oral Biology. 39 (Supplement). 159 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasunori Nakamura et al: "Inhibitory effect of a new electrically oxidized water on caries development in rats inoculated with S. sobrinus 6715"SHIGAKU. 86 (2). 335-342 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasunori Nakamura et al: "Inhibitory effect of quaternary ammonium salts on caries development in rats inoculated with S. sobrinus"Japanese Journal of Oral Biology. 40 (Supplement). 156 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Haruhiro Kuwashima, Yasunori Nakamura et al: "Inhibitory effect of dequalinium chloride on caries development in rats inoculated with S. sobrinus"Japanese Journal of Oral Biology. 40 (Suppliment). 157 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasunori Nakamura et al: "Inhibitory effect of quaternary ammonium salts on water-insoluble glucan synthesis by cariogenic bacterium"Japanese zjournal of Oral Biology. 40 (6). 648-655 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasunori Nakamura et al: "Inhibitory effect of sodium alginate on caries development in rats inoculated with Streptococcus sobrin us 6715"SHIGAKU. 87 (4). 530-536 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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