2000 Fiscal Year Final Research Report Summary
RESEARCH ON THE FOOD FUNCTIONAL COMPONENTS IN SMALL FRUITS FROM NORTHERN AREA.
| Project/Area Number |
09680051
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
家政学
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| Research Institution | AKITA PREFECTURAL UNIVERSITY (1999-2000)
Hokkaido Bunkyo University Junior College (1997-1998) |
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Principal Investigator |
KAWAII Yuko (吉澤 結子) AKITA PREFECTURAL UNIVERSITY BIOTECHNOLOGY ASSOCIATE PROFESSOR, 生物資源科学部, 助教授 (20269202)
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| Project Period (FY) |
1997 – 2000
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| Keywords | Actinidia polygama / ACE / anti-hypertension / HL-60 / ANTI-CANCER |
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| Research Abstract |
Epidemiological studies indicate that high intake of fruits and vegetables are associated with a reduced risk of hypertension and cancer, and several plant-derived drugs have been already developed. Since only a small part of the flora has been tested for any kind of bioactivity, we chose small fruits as sources of inhibitory activity of angiotensin I-converting enzyme (ACE), differentiation-inducing activity against HL-60 leukemia cells, and antiproliferative activity toward several cancer cell lines. We have prepared juices from various small fruits that are mainly growing in northern part of Japan. Among 43 samples, 6 juices namely Elaeagnus multiflora Thunb., Elaeagnus umbellata Thunb., Rubus idaeus L., Ribes latifolium Janczewski, Ribes nigrum Linn., and Alonia melanocarpa exhibited ACE inhibition, while juices of Vaccinium smallii A.Gray, Sorbus sambucifolia Roem., Rosa rugosa Thunb., Actinidia polygama Maxim. demonstrated potent differentiation-inducing and antiproliferative activities, and yet low cytotoxicity toward normal human cell lines. The results demonstrated the feasibility of the physiological screening on the small fruits in order to identify plants rich in anti-hypertensive and/or anticancer substances.
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