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1998 Fiscal Year Final Research Report Summary

Prion protein-deficient mice : neuronal abnormalities in the cerebellum and spinal cord

Research Project

Project/Area Number 09680752
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Nerve anatomy/Neuropathology
Research InstitutionKansai Medical University

Principal Investigator

SUGIMOTO Tetsuo  Kansai Medical University, Faculty of Medicine Professor, 医学部, 教授 (90144352)

Project Period (FY) 1997 – 1998
KeywordsPrion protein / Knockout mouse / Purkinje cell / Cerebellum / Spinal cord
Research Abstract

Disruption of both alleles of the prion protein gene, Prnp, renders mice resistant to prions. In one PrnpO/O line, such older mice developed ataxia and Purkinje cell loss. We found torpedo-like axonal swellings associated with residual Purkinje cells in PrnpO/O mice and demonstrated abnormal myelination in the spinal cord and peripheral nerves in mice from two independently established PrnpOfO lines. Both demyelination and Purkinje-cell degeneration weresuccessfully rescued by introduction of a transgene encoding wild-type mousecellular prion protein (PrPc). Together, these findings provide firm evidence that PrPc is indispensable for neuronal integrity.

  • Research Products

    (3 results)

All Other

All Publications (3 results)

  • [Publications] Katamine, S: "Impaired motor coodination in mice lacking prion protein" Cell Molec. Neurobiol.18. 731-742 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 杉本哲夫: "プリオン蛋白欠損動物の運動失調と脳・脊髄所見" 解剖学雑誌. 72. 322 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shigeru Katamine, Noriyuki Nishida, Tetsuo Sugimoto, Tetsuo Noda, Suehiro Sakaguchi, Kazuto Shigematsu, Yasufumi Kataoka, Akira Nakatani, Sumitaka Hasegawa, Ryozo Moriuchi and Tsutomu Miyamoto.: "Impaired motor coord.ination in mice lacking prion protein." Cell.Molec.Neurobiol.18(6). 731-742 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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