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1998 Fiscal Year Final Research Report Summary

Research on a novel endogenous catecholamine, 6-nitronorepinephrine

Research Project

Project/Area Number 09680771
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurochemistry/Neuropharmacology
Research InstitutionTeikyo University

Principal Investigator

NAKAKI Toshio  Teikyo University, School of Medicine Department of Pharmacology, Assistant Professor, 医学部, 助教授 (30164148)

Project Period (FY) 1997 – 1998
Keywordsnitric oxide / catecholamine / blood vessels / catalase / hydrogen peroxide
Research Abstract

Vasoactivities of 6-nitronorepineplirine were investigated using rat aorta. 6-Nitronorepinephrine (>100 muM) caused dose-dependent contraction in both endothelium-intact and -denuded aorta, although the latter showed greater contraction than the former. Prazosin (>3 nM), an alpha_1-adrenoceptor antagonist, attenuated significantly the 6- nitronorepinephrine-induced contractions, thereby suggesting the alpha_1-adrenoceptor involvement. Aortic rings prepared from reserpine-pretreated rats showed the 6-nitronorepinephrine-induced a contraction tothe extent similar to those from untreated rats, suggesting that endogenous norepinephrine does not play a role in the 6-nitronorepinephrine-induced contraction. 6-Nitronorepinephrine (>10 muM) potentiated norepinephrine-induced contraction only in the presence of endothelium. The augmentation was attenuated by catalase (1,200U/ml). H_2O_2 (10-300 muM) augmented the norepinephrine-induced contraction only in the endothelium-intact rat aortic rings. 6-Nitronorepinephrine attenuated significantly acetyicholine-induced relaxation. Catalase prevented the 6-nitronorepinephrine-induced inhibition of the acetylcholine-induced relaxation. These results suggest that 6-nitronorepinephrine has a weak txi-adrenoceptor agonistic property and that the endothelium-dependent potentiation by 6-nitronorepinephrine of the norepinephrine-induced contraction is mediated through production of H_20_2. Roles of superoxide in the formation of 6-nitronorepinephrine and distribution of the amine in the brain are being currently investigated.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Nakaki, T.: "Endothelium-independent and-dependent vasoactivity of 6-nitronorepinephrine" Eur J Pharmacol. 357. 193-197 (1998)

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  • [Publications] 中木, 敏夫: "生体内ニトロ化, ニトロソ化, ニトロシル化による機能修飾" 日本薬理学雑誌. 112. 161-168 (1998)

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      「研究成果報告書概要(和文)」より
  • [Publications] 中木 敏夫: "高血圧とNO" 臨床神経科学. 16. 90-93 (1998)

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      「研究成果報告書概要(和文)」より
  • [Publications] 中木, 敏夫: "血管トーヌスに対する柴胡加竜骨牡蛎湯の内皮依存性および非依存性作用" Progress in Medicine. 18. 710-714 (1998)

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      「研究成果報告書概要(和文)」より
  • [Publications] 中木, 敏夫: "呼吸器疾患治療薬" 臨床看護. 24. 786-792 (1998)

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  • [Publications] 鈴木, 映二: "向精神薬投与による脳内インターロイキン-1βとインターロイキン受容体アンタゴニストのmRNA濃度の変化" 精神薬療基金研究年報. 29. 201-207 (1998)

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  • [Publications] Nakaki, T., Fujii, T., Suzuki, E.and Shintani, F.: "Endothelium-independent and -dependent vasoactivity of 6-nitronorepinephrine." Eur.J.Pharmacol.357. 193-197 (1998)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Nakaki, T.and Fujii, T.: "Biological significance of nitration, nitrosation and nitrosylation in vivo." Jpn.J.Pharmacol.112. 161-168 (1998)

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  • [Publications] Nakaki, T.: "Hypertension and NO." Clinical Neuroscience. 16. 90-93 (1998)

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  • [Publications] Nakaki, T.: "Endothelium-dependent and -independent vasoactivities of a Japanese Kampo medicine." Progress in Medicine. 18. 710-714 (1998)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Nakaki, T.: "Drugs used for the treatment of pulmonary diseases." Jpn J Clin Nurs Month. 24. 786-792 (1998)

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      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki, E.: "Chronic treatment with various psychotropics elevates mRNA levels of both interleukin-1b and interleukin-1 receptor antagonist in the rat brain." Ann Rep Pharmacopsychiat Res Found. 29. 201-207 (1998)

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  • [Publications] Nakaki, T.: Medical Pharmacology.Chugai Igakusha, Tokyo, 562 (1997)

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  • [Publications] Nakaki, T.: Cardiovascular Diseases and NO.Kinpodo, Tokyo, 210 (1998)

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Published: 1999-12-08  

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