• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1998 Fiscal Year Final Research Report Summary

Development of Low-Invasive Estimation System of Maximum Ventricular Elastance Emax Under Assisted Circulation

Research Project

Project/Area Number 09680841
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTohoku University

Principal Investigator

YOSHIZAWA Makoto  Grad.Sch.of Eng., Tohoku Univ., Assoc.Prof., 大学院・工学研究科, 助教授 (60166931)

Co-Investigator(Kenkyū-buntansha) YAMBE Tomoyuki  Inst.of Development, Aging and Cancer, Tohoku University, Assoc.Prof., 大学院・加齢医学研究所, 助教授 (70241578)
ABE Ken-ichi  Grad.Sch.of Eng., Tohoku Univ., Prof., 大学院・工学研究科, 教授 (70005403)
NITTA Shin-ichi  Inst.of Development, Aging and Cancer, Tohoku University, Prof., 大学院・加齢医学研究所, 教授 (90101138)
Project Period (FY) 1997 – 1998
KeywordsEmax / maximum ventricular elastance / estimation / low-invasive / assisted circulation / cardiac function / Ees / inverse problem
Research Abstract

The maximum ventricular elastance (Emax) will be a good quantitative index for weaning the patient from the ventricular assist device if the Emax can be obtained low-invasively. The purpose of this research was to develop a method for estimating the Emax beat-to-beat and less-invasively.
First, it was formulated that the process for estimating the Emax is a kind of inverse problem. This leaded to an algorithm for estimating the Emax beat-to-beat on the basis of only two measurements : ventricular pressure and ventricular volume or aortic flow.
Second, the algorithm was implemented on a personal computer system to calculate Emax in a real-time fashion.
Third, the animal experiments using goats were carried out in many situations with change in preload and afterload or with injections for changing cardiac function. The data obtained from the experiments)showed that the correlation coefficient of the Emax between the proposed method and the traditional method was about 0.9. This indicates that the proposed method is sufficiently useful for monitoring cardiac function. Furthermore, it could be shown that the proposed method is superior to the traditional methods because the estimation error can be evaluated quantitatively as an error with respect to the intercept of the end-systolic pressure volume regression line.
To apply the proposed method to actual clinical settings, the proposed method must be further improved so that another less-invasive information like aortic pressure instead of ventricular pressure can be used for estimating the Emax.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Makoto Yoshizawa: "Classical but effective techniques for estimating cardiovascular dynamics" IEEE Engineering in Medicine and Biology Magazine. 16・5. 106-112 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 田中明: "人工心臓用適応制御系の同定能力と安定性の評価" 人工臓器. 26・1. 114-118 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 吉澤誠: "総論:生体循環系の推定と制御" 計測と制御. 38・5印刷中. (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Makoto Yoshizawa: "Heart Replacement-Artificial Heart6 (T.Akutsu ed. )" Springer-Verlag, 521 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Yoshizawa: "Classical but effective techniques for estimating cardiovascular dynamics" IEEE Eng.in Med.and Biol.Magazine. 16 (5). 106-112 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] A.Tanaka: "Experimental analysis of identification function and stability of an adaptive controller for total artificial heart" Jap.J.Artificial Organs. 26 (1). 114-118 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Yoshizawa: "Estimation and control of circulatory systems" J.of Soc.Instrument and Control. 38 (5), (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Yoshizawa: "Heart Replacement--Artificial Heart 6 (T.Akutu ed.)" Springer-Verlag. 521. (1998)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1999-12-08  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi