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1998 Fiscal Year Final Research Report Summary

Preparation of dimethylsiloxane type of block copolymer * with nonthrombogenicity as biomedical materials

Research Project

Project/Area Number 09680869
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKINKI UNIVERSITY

Principal Investigator

SUGIYAMA Kazuo  Kinki Univ.Dept.of Eng. : Professor, 工学部・工業化学科, 教授 (00088577)

Co-Investigator(Kenkyū-buntansha) OKADA Kiyotaka  Kinki Univ.School of Medicine : Assistant, 医学部, 助手 (20185432)
MATSUO Osamu  Kinki Univ.School of Medicine : Professor, 医学部, 教授 (40030879)
SHIRAISHI Kohei  Kinki Univ.Dept.of Eng : Associated Professor, 工学部・工業化学科, 助教授 (10196602)
Project Period (FY) 1997 – 1998
KeywordsPhospholipid monomer / Polydimethylsiloxane / Block copolymer / Macroazo initiator / Hydrogel layer / Polyether urethane / Protein adsorption / Thrombogenicity
Research Abstract

1. Polyetherurethaneureas including tetramethyldisiloxane(TMDS) moiety in main chain were obtained frompolyaddition of polytetrahydrofuran to 4, 4'-diphenylmethane diisocyauate in the presence of 3-bis(hydroxypropyl)-tetramethyldisiloxane, using ethylenediamine as a chain extension reagent. It was found that the TMDS moiety was located on the surface of the PEUU-Si film in air and that PEUU-Si adsorbed albumin.
2. Surface modified poly(ethylene terephthalate) (PET) films with the 2-(methacryloyloxy)ethyl phosphoryicholine(MPG), PMPC-g-PET, was prepared by plasma irradiation-post polymerization technique. PMPC-g-PET adsorbsless serum proteins than the original PET film. Lecithin adsorbed on PMPC-g-PET which showed activity for the inhibition of fibrin formation and no adhesion of mouse fibroblasts (L-929) and platelets.
3. Poly(methyl methaciylate) microspheres modified with L-serine and L-proline moieties were prepared by emulsion copolymerization of methyl methacrylate with O-methacryloyl-L-serine or -L-proline. Amino acid moieties located on the surface of particles. It was found that the adsorption of proteins on particle was effectively suppressed.
4. A series of polydimethylsiloxane block copolymers containing PMPC, poly[2-(hydroxyethyl) methacrylate], poly(2, 3-dihydroxypropyl methacrylate), and poly(l-methacryloyloxy dulcitol) as hydrophilic segments were prepared by radical polymerization of corresponding monomers initiated with polydimethylsiloxane type of azo-initiator. It was found in water that the hydrophilic segments migrated to the surface of copolymer which suppressed the adsorption of serum proteins as well as platelets, less than the original polydimethylsiloxane as control. The block copolymer containing PMPC segment showed no adhesion of L-929 and platelets.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 杉山一男、秋山修作、友井陽子、花木香織、白石浩平、上田兼二: "ハードセグメントにメチルあるいはフッ素置換ビフェニルジイル基をもつポリエーテルウレタン尿素の合成と性質" 日本化学会誌. 1997. 139-146 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 杉山一男、光野聡、白石浩平: "Adsorption of protein on the surface of thermosensitive poly(methyl methacrylate) microspheres modfied with the N-(2-hydroxypropyl)methacrylamide and 2-(methacryloyloxy)ethyl phosphorylcholine moieties" J.Polym.Sci : Part A : Polym. Chem.35. 3349-3357 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 杉山一男、磯部佳愛、白石浩平: "ポリエーテルウレタン尿素へのテトラメチルジシロキサンセグメントの導入" 日本化学会誌. 1997. 816-820 (1997)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 杉山一男、加藤和哉、木戸正和、白石浩平、大賀幸二、岡田清孝、松尾理: "Grafting of vinyl monomers on the surface of a poly(ethylene terephthalate)film using Ar plasma-post polymerization technique to increase biocompatibility" Macromol.Chem.Phys.199. 1201-1208 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 杉山一男、谷川将行、白石浩平: "親水性ポリメタクリレートセグメントを含むポリジメチルシロキサンブロックコポリマーのキャラクタリゼーション" 日本化学会誌. 1988. 551-557 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 白石浩平、大西恒久、杉山一男: "Preparation of poly(methyl methacrylate)microspheres modified with amino acid moieties" Macromol.Chem.Phys.199. 2023-2028 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kazuo Sugiyama: "Preparation and characterization of polyetherurethaneureas containing methyl-or fluoro substituted biphenyldiyl in hard Segments" Nihon Kagaku Kaishi. 139-146 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kazuo Sugiyama: "Adsorption of protein on the surface of thermosensitive poly (methyl methacrylate) microspheres modified with the N-(2-hydroxypropy)-methacrylamide and 2-(methacryloyloxy) ethyl phosphorylcholine moieties" J.Polym.Sci. : Part A : Palym.Chem.35. 3349-3357 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kohei Shiraishi: "Surface modified poly (methyl methacrylate) microspheres with the O-methacryloyl- L-serine moiety" Chem, Lett.1997. 816-820 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kazuo Sugiyama: "Introduction of Tetramethyldisiloxane moiety into polyetherurethaneurea" Nihon Kagakkaishi. 1997. 816-820 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kazuo Sugiyama: "Grafts of vinyl monomers on the surface of a poly (ethylene terephthalate) film using Ar plasma-post polymerization technique of increase biocompatibility" Makromol.Cham.199. 1201-1208 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kazuo Sugiyama: "Characterization of polydimethylsiloxane block copolymers containing hyfrophilic polymethacrylate segment" 551-557 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kohei Shiraishi, Tsunehisa Ohnishi, Kazuo Sugiyama.: "Preparaton of poly (methyl methacrylate) microspheres modified with amino acid moieties" Makromol.Chem.199. 2023-2028 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kohei Shiraishi: "Biocompatiblec block copolymers composed of polydimethylsiloxane and poly [ (2-methacryloyl-oxy) ethyl phosphorylcholine]segments ; contribution to Makromoil" Chem. Rapid. Commun.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1999-12-08  

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