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1999 Fiscal Year Final Research Report Summary

Studies on genetic characteristics of Drosophila simulans.

Research Project

Project/Area Number 09839015
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 自然史科学
Research InstitutionKYOTO INSTITUTE OF TECHNOLOGY

Principal Investigator

YAMAMOTO Masa-toshi  Drosophila Genetic Resource Center, Kyoto Inst. Technology, Professor, ショウジョウバエ遺伝資源センター, 教授 (10142001)

Project Period (FY) 1997 – 1999
Keywordsspeciation gene / hybrid lethality / Drosophila simulans / spermatogenesis / chromosome aberration / transposon
Research Abstract

Drosophila simulans is one of the closely related species to Drosophila melanogaster which is the best analyzed genetic material used widely in many different fields of biological research. The findings obtained from Drosophila melanogaster is tend to understand to be general properties of genetic systems. However there exist a few characteristics specific to D. simulans but no similar phenotype had been described in D. melanogaster. It is important to characterize the species specific biological phenomena in order to understand the speciation mechanisms from the genetics view points. The research has been carried out for the following biological phenomena known to be restricted to D. simulans.
1. sex-ratio genes : In spermatogenesis the Y chromosome bearing sperms are eliminated and produced mostly the X chromosome bearing sperms. Electron microscopical studies demonstrated abnormalities in the chromatin segregation and condensation.
2. Cytological mapping of the Lhr gene : Hybrid femal … More es from the cross between D. melanogaster females and D. simulans males are lethal. The Lethal hybrid rescue (Lhr) gene rescues the lethality and lets the hybrids to survive to adulthood. Because no homologous gene to Lhr has been identified in D. melanogaster, cytological location of the gene had been analyzed by making hybrids using some newly isolated visible mutations of D. simulans.
3. Synthesis of chromosome aberrations and making a balancer chromosome stock : Two third-chromosome inversions, a ring X chromosome including a large inversion have been made and analyzed genetically and cytologically. Marked Y chromosomes were also synthesized and fragmented Y chromosomes were produced.
4. Characterization of the ninja transposon : An extensive molecular survey demonstrated that the ninja retrotransposon is D. simulans specific transposon.
5. Molecular analysis of highly unstable mutation of white-Sa : A highly unstable (10ィイD1-2ィエD1) white mutation (wィイD1S2ィエD1) has been analyzed and shown to carry an about 3kb mariner-like insertional. Less

  • Research Products

    (10 results)

All Other

All Publications (10 results)

  • [Publications] Hatano, Y.: "Further genetic studies on the Katsunuma population of Drosophila melanogaster"Genes & Genetic Systems. 74. 219-225 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Itoh, M.: "Structure of the proliferation disrupter (prod) gene of Drosophila simulans and D. melanogaster"Genetica. 印刷中. (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K. Sawamura: "Characterization of a reproductive isolation gene, zygotic hybrid rescue, of Drosophila melanogaster by using minichromosomes."Heredity. 79. 97-103 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] G. Miklos: "An essential cell division gene of Drosophila, absent from Saccharomyces, encodes an unusual protein with tublin-like and myosin-like peptide motifs."Proc. Natl. Acad. Sci. USA. 94. 5189-5194 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M-T. Yamamoto: "Cytogenetic mapping of the Lethal hybrid rescue gene of Drosophila simulans."Genes & Genetic Systems. 72. 297-301 (1997)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Matsubayashi: "Dissection of chromosome region 89A of Drosophila melanogaster by local transposition of P elements."Genes & Genetic Systems. 73. 95-103 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M-T. Yamamoto: "Drosophila genetic resources necessary for the progress of life science research."Tanpakushitsu Kakusan Kouso. 43. 1479-1483 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Kanamori: "Molecular identification of the active ninja retrotransposon and the inactive aurora element in Drosophila simulans and D. melanogaster."Genes & Genetic Systems. 73. 385-396 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Hatano: "Further genetic studies on the Katsunuma population of Drosophila melanogaster."Genes & Genetic Systems. 73. (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Itoh: "Structure of the proliferation disrupter (prod) gene of Drosophila simulans and D. melanogaster."Genetica. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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