1997 Fiscal Year Annual Research Report

正の自然淘汰の働く遺伝子内領域の推定に基づく遺伝子機能とその変化の予測

Research Project

Project/Area Number	09874159
Research Institution	National Institute of Genetics
Principal Investigator	五條堀孝国立遺伝学研究所, 生命情報研究センター, 教授 (50162136)
Co-Investigator(Kenkyū-buntansha)	今西規国立遺伝学研究所, 生命情報研究センター, 助手 (80270461) 池尾一穂国立遺伝学研究所, 生命情報研究センター, 助手 (20249949)
Keywords	正の自然淘汰 / 遺伝子機能 / DNA配列 / 遺伝子内領域
Research Abstract	本研究は、現在世界中で進行している各種生物のゲノムプロジェクトを受けて、そこから産生される膨大なゲノムの塩基配列データを用いて、相同遺伝子グループを同定するとともに、それぞれのグループごとでマルチプルアラインメントを作成し、遺伝子機能の推定を行うことにある。特に、正の自然淘汰が働いている遺伝子内領域の推定を行い、それらと機能的ドメインとの対応関係を調べることによって、遺伝子のドメイン進化の予測を行う方法を探索しようというものであった。本年度は、相同遺伝子グループのマルチプルアライメント作成のアルゴリズムを洗練させることに成功した。ただ機能的ドメインの同定に少し手こづっており、これはもう少し時間を要する。しかし、遺伝子内において正の自然淘汰の働く領域の推定には、ウィンドウ解析を同義置換と非同義置換に行いうるというアイデアで、うまくいくことが実証され、そのプログラムも完成した。これらは遺伝子機能やその変化の予測に多いに役立つものと期待される。

Research Products
(14 results)

All Other

All Publications (14 results)

[Publications] Tateno Y.: "Evolutionary motif and its biological and structural significance." J.Mol.Evol.44・1. 38-43 (1997)
[Publications] Watanabe H.: "Genome plasticity as a paradigm of eubacteria evolution." J.Mol.Evol.44・1. 57-64 (1997)
[Publications] Yamaguchi Y.: "Evolutionary mechanisms and population dynamics of the third variable envelope region of HIV within single hosts." Proc.Natl.Acad.Sci.U.S.A.94. 1264-1269 (1997)
[Publications] Sato S.: "Ascidian tyrosinase gene : Its unique structure and expression in the developing brain." Developmental Dynamics. 208. 363-374 (1997)
[Publications] Tenzen T.: "Precise switching of DNA replication timing in the GC content transition area in the human Major Histocompatibility Complex." Mol.and Celular Biology. 17・7. 4043-4050 (1997)
[Publications] Okamoto Y.: "Father-to-mother-to-infant transmission of HIV-1 : clonally transmitted isolate of infant mutates more rapidly than that of the mother and rapidly loses reactivity with neutralizing antibody." Microbiol Immunol. 42・2. 131-138
[Publications] Watanabe H.: "Bacterial features in the genome of methanococcus jannaschii in terms of gene composition and biased base composition in ORFs and their surrounding regions." GENE. 205. 7-18 (1997)
[Publications] Suzuki Y.: "The origin and evolution of human T-Cell hymphotrophic virus type I and II." Virus Genes. 16・1. 69-84 (1998)
[Publications] Perrie reG.: "The NRSub database : update 1997." Nucl.Acids Res.25・1. 53-56 (1997)
[Publications] Nakamura Y.: "Codon usage tabulated from the international DNA sequence databases." Nucl.Acids.Res.25・1. 244-245 (1997)
[Publications] Mizokami M.: "Constrained evolution of hepatitis B virus with overlapping genes." J.Mol.Evol.44・1. 83-90 (1997)
[Publications] Suzuki Y.: "The origin and evolution of ebola and marburg viruses." Mol.Biol.Evol.14・8. 800-806 (1997)
[Publications] Kurihara T.: "Molecular evolution of myelin proteolipid protein." Biochemical and Biophysical Research Communications.237. 559-561 (1997)
[Publications] Endo T.: "Evolutionary significance of intra-genome duplications on human chromosomes." GENE. 205. 9-27 (1997)

1997 Fiscal Year Annual Research Report

正の自然淘汰の働く遺伝子内領域の推定に基づく遺伝子機能とその変化の予測

Principal Investigator

五條堀 孝 国立遺伝学研究所, 生命情報研究センター, 教授 (50162136)

Research Products

[Publications] Tateno Y.: "Evolutionary motif and its biological and structural significance." J.Mol.Evol.44・1. 38-43 (1997)

[Publications] Watanabe H.: "Genome plasticity as a paradigm of eubacteria evolution." J.Mol.Evol.44・1. 57-64 (1997)

[Publications] Yamaguchi Y.: "Evolutionary mechanisms and population dynamics of the third variable envelope region of HIV within single hosts." Proc.Natl.Acad.Sci.U.S.A.94. 1264-1269 (1997)

[Publications] Sato S.: "Ascidian tyrosinase gene : Its unique structure and expression in the developing brain." Developmental Dynamics. 208. 363-374 (1997)

[Publications] Tenzen T.: "Precise switching of DNA replication timing in the GC content transition area in the human Major Histocompatibility Complex." Mol.and Celular Biology. 17・7. 4043-4050 (1997)

[Publications] Okamoto Y.: "Father-to-mother-to-infant transmission of HIV-1 : clonally transmitted isolate of infant mutates more rapidly than that of the mother and rapidly loses reactivity with neutralizing antibody." Microbiol Immunol. 42・2. 131-138

[Publications] Watanabe H.: "Bacterial features in the genome of methanococcus jannaschii in terms of gene composition and biased base composition in ORFs and their surrounding regions." GENE. 205. 7-18 (1997)

[Publications] Suzuki Y.: "The origin and evolution of human T-Cell hymphotrophic virus type I and II." Virus Genes. 16・1. 69-84 (1998)

[Publications] Perrie reG.: "The NRSub database : update 1997." Nucl.Acids Res.25・1. 53-56 (1997)

[Publications] Nakamura Y.: "Codon usage tabulated from the international DNA sequence databases." Nucl.Acids.Res.25・1. 244-245 (1997)

[Publications] Mizokami M.: "Constrained evolution of hepatitis B virus with overlapping genes." J.Mol.Evol.44・1. 83-90 (1997)

[Publications] Suzuki Y.: "The origin and evolution of ebola and marburg viruses." Mol.Biol.Evol.14・8. 800-806 (1997)

[Publications] Kurihara T.: "Molecular evolution of myelin proteolipid protein." Biochemical and Biophysical Research Communications.237. 559-561 (1997)

[Publications] Endo T.: "Evolutionary significance of intra-genome duplications on human chromosomes." GENE. 205. 9-27 (1997)

五條堀孝国立遺伝学研究所, 生命情報研究センター, 教授 (50162136)