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1999 Fiscal Year Final Research Report Summary

Anthhropological and genetic studies on ocular inflammatory diseases in Mongoloids

Research Project

Project/Area Number 10041203
Research Category

Grant-in-Aid for Scientific Research (A).

Allocation TypeSingle-year Grants
Section一般
Research Field Ophthalmology
Research InstitutionYokohama City University

Principal Investigator

OHNO Shigeaki  School of Medicine, Yokohama City University, Professor, 医学部, 教授 (50002382)

Co-Investigator(Kenkyū-buntansha) SUGITA Miyuki  School of Medicine, Yokohama City University, Associate Professor, 医学部, 助教授 (90235888)
ONOUE Kazunori  Hokkaido Univ Institute of Immun Sci Professor, 免疫科学研究所・免疫病理部, 所長(教授) (40002117)
INOKO Hidetoshi  Tokai Univ Sch of Med Professor, 医学部・分子生命科学, 教授 (10101932)
UCHIO Eiichi  Medical Center, Yokohama City University, Associate Professor, 医学部・附属病院・市民総合医療センター, 助教授 (70232840)
NAKAMURA Satoshi  School of Medicine, Yokohama City University, Assistant Professor, 医学部, 講師 (00237398)
Project Period (FY) 1998 – 1999
KeywordsMongoloid / Intractable ocular diseases / Uveitis / Human genetics / Molecular genetics / Behcet's disease / Vogt-Koyanagi-Harada disease / HLA
Research Abstract

It is well known that certain intractable inflammatory ocular diseases occur only in Mongoloid population. We have been studying the epidemiology, clinical feature, medical anthropology, and molecular genetics in mainly Vogt-Koyanagi-Harada disease and Behcet's disease.
It was revealed that Vogt-Koyanagi-Harada disease was found in East Asian countries, Central Asian countries, North America and South America. In contrast, in Caucasians, this disease was rarely found. Vogt-Koyanagi-Harada disease was frequently seen in Australian Aborigini people, and possibly, in Papua New Guinean population. Since this disease is strongly associated with HLA-DRB1ィイD1*ィエD104 in East Asian patients, it is important to further study if the same HLA association is found in other populations.
In Behcet's disease, no patients were found in East Asian countries. This disease was mainly found along the Silk Road, such as Korea, China, Iran, Turkey, and Morocco. In these countries, the number of new cases is still increasing and further epidemiological studies are needed to investigate the possible cause for this. In 1998's investigation we saw patients with Behcet's disease in Mongolia. This is the first report of the world. We have finished analyzing the molecular genetics of Greek patients with Behcet's disease. The frequency of HLA-BィイD1*ィエD15101 was 81.1 %, significantly higher than the healthy normal Greek controls. MICA-A6, one of the microsatellite alleles near the HLA region, was also significantly associated with this disease. It was interesting to find the same HLA association between Japanese and Greek patients with Behcet's disease.
We have successfully gotten the blood samples from typical patients with Behcet's disease in Iran and Turkey. And it is expected that we could also get the samples from Morocco. Further HLA-DNA analyses will be performed in the near future.

  • Research Products

    (54 results)

All Other

All Publications (54 results)

  • [Publications] 竹内聡: "アジア諸国のウイルス性結膜炎ー国際サーベイランス"臨眼. 52. 513-516 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nanba K.: "Identification of a peptide inducing experimental autommune uveoretinitis (EAU) in H-2Ak- carrying mice"Clin Exp Immunol. 111. 442-449 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sugi-Ikai N.: "Increased frequencies of interleukin-2 and interferon-γーproducing T cells in patients with active Behcet's disease"Invest Ophthalmol Vis Sci. 39. 996-1004 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 石原麻美: "サルコイドーシスとライム病"日本の眼科. 69. 23-26 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimura T.: "Microsatellite polymorphism within the MICB gene among Japanese patients with Behcet's disease"Hum Immunol. 59. 500-502 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishida T.: "Proliferative response of CD8+gd+T cells to Streptococcus sanguis in patients with Behcet's disease"Ocular Immunology and Inflammation. 6. 139-144 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uchio E.: "HSP-derived peptides inducing Uveitis and IgG and IgA antibodies"Exp. Eye Res.. 67. 719-727 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ishihara M.: "Seroprevalence of anti-Borrelia antibodies among patients with confirmed sarcoidosis a region of Japan where Lyme borreliosis is endemic"Grafe's Arch Clin Exp Ophthalmol. 236. 280-284 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 鈴木高佳: "難治性眼サルコイドーシスの2症例"臨眼. 52. 481-485 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 石原麻美: "眼科領域における結核"日本臨牀. 56. 163-167 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大野重昭: "ベーチェット病研究の最前線"Current Topics on Behcet Disease. 2-3 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大野重昭: "Interview"Current Topics on Behcet Disease. 6-7 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yawata N.: "High incidence of glucose intolerance in Vogt-Koyanagi-Harada disease"Br J Ophthalmol. 83. 39-42 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uchio E.: "Soluble intercellular adhesion molecule-1(ICAM-1), CD4, CD8 and interleukin-2 receptor in patients with Behcet's disease and Vogt-Koyanagi-Harada's disease"Clin Exp Rheumatol. 117. 179-184 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yabuki K.: "Association of MICA gene and HLA-B^*5101 with Behcet's disease in Greece"Invest Ophthalmol Vis Sci. 40. 1921-1926 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ota M.: "The critical region for Behcet's disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA-B, by association analysis using refined microsatellite mapping"Am J Hum Genet. 64. 1406-1410 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yabuki K.: "HLA class I and II typing of the patients with Behcet's disease in Saudi Arabia"Tissue Antigens. 54. 273-277 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uchio E.: "Ocular manifestations of systemic infections"Current Opinion in Ophthalmology. 10. 452-457 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yabiki K.: "Triplet repeat polymorphism in the MICA gene in HLA-B27 positive and negative Caucasian patients with ankylosing spondylitis"Hum Immunol. 60. 83-86 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mizuki N.: "Association analysis between the MIC-A and HLA-B alleles in Japanese patients with Behcet's disease"Arthritis Rheum. 42・9. 1961-1966 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujino Y.: "Ciclosporin microemulsion preconcentrate treatment of patients with Behcet's disease"Jpn J Ophthalmol. 43. 318-326 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura S.: "Uveitis Today"Elsevier Science. 333 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shindo Y.: "Uveitis Today"Elsevier Science. 333 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uchio E.: "Uveitis Today"Elsecier Scoence. 333 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大野重昭: "実践眼底疾患"メディカル葵出版. 446 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yabuki K.: "Uveitis Update (Dev Ophthalmol)"Karger. 216 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Goto K.: "Ocular Inflammation (Basic and Clinical Concepts)"Martion Dunitz. 512 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takeuchi S.: "Surveillance of viral conjunctivitis in Asian countries"Jpn J Clin Ophthalmol. 52. 513-516 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nanba K.: "Identification of a peptide inducing experimental autoimmune uveoretinitis (EAU) in H-2Ak-carrying mice"Cliln Exp Immunol. 111. 442-449 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sugi-Ikai N.: "Increased frequencies of interleukin-2-and interferon-Ej-producing T cells in patients with active Behcet's disease"Invest Ophthalmol Vis Sci. 39. 996-1004 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishihara M.: "Association between sarcoidosis and Lyme disease"J Jpn Ophthalmologists Assoc. 69. 23-26 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura T.: "Microsatellite polymorphism within the MICB gene among Japanese patients with Behcet's disease"Hum Immunol. 59. 500-502 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishida T.: "Proliferative response of CD8+gd+T cells to Streptococcus sanguis in patients with Behcet's disease"Ocular Immunology and Inflammation. 6. 139-144 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uchio E.: "HSP-derived peptides inducing Uveitis and IgG and IgA antibodies"Exp.Eye Res.. 67. 719-727 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishihara M.: "Seroprevalence of anti-Borrelia antibodies among patients with confirmed sarcoidosis in a region of Japan where Lyme borreliosis is endemic"Graefe's Arch Clin Exp Ophthalmol. 236. 280-284 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki T.: "Two cases of recalcitrant ocular sarcoidosis"Jpn J Clin Ophthalmol. 52. 481-485 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishihara M.: "Ocular tuberculosis"Nippon Rinsho. 56. 163-167 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohno S.: "Frontier in the study of Behcet's disease"Current Topics on Behcet Disease. 2-3 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohno S.: "Interview on Behcet's disease"Current Topics on Behcet Disease. 6-7 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yawata N.: "High incidence of glucose intolerance in Vogt-Koyanagi-Harada disease"Br J Ophthalmol. 83. 39-42 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uchio E.: "Soluble intercellular adhesion molecule-1(ICAM-1), CD4, CD8 and interleukin-2 receptor in patients with Behcet's disease and Vogt-Koyanagi-Harada's disease"Clin Exp Rheumatol. 17. 179-184 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yabuki K.: "ssociation of MICA-gene and HLA-BィイD1*ィエD1101 with Behcet's disease in Greece"Invest Ophthalmol Vis Sci. 40. 1921-1926 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ota M.: "The critical region for Behcet's disease in the human major histocompatibility complex is reduced to a 46-kb segment centromeric of HLA-B, by association analysis using refined microsatellite mapping"Am J Hum Genet. 64. 1406-1410 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yabuki K.: "HLA class I and II typing of the patients with Behcet's disease in Saudi Arabia"Tissue Antigens. 54. 273-277 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uchio E.: "Ocular manifestations of systemic infections"Current Opinion in Ophthalmology. 10. 452-457 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yabuki K.: "Triplet repeat polymorphism in the MICA gene m HLA-B27 positive and negative Caucasian patients with ankylosing spondylitis"Hum Immunol. 60. 83-86 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mizuki N.: "Association analysis between the MIC-A and HLA-B alleles in Japanese patients with Behcet's disease"Arthritis Rheum. 42. 1961-1966 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujino Y.: "Ciclosporin microemulsion preconcentrate treatment of patients with Behcet's disease"Jpn J Ophthalmol. 43. 318-326 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura S.: "The resistance for apoptosis on activated T cells in Behcet's disease"Uveitis Today Elsevier Science. 333 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shindo Y.: "Immunogenetic studies of Vogt-Koyanagi-Harada's disease and sympathetic ophthalmia"Uveitis Today Elsevier Science. 333 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uchio E.: "Humoral immune response in heat shock potein (HSP)-induced rat uveitis"Uveitis Today Elsevier Science. 333 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohno S.: "Intermediate uveitis"Practical Book on Ocular Fundi Medical Aoi Publisher.Inc. 446 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yabuki K.: "Immunogenetics and uveitis"Uveitis Update (Dev Ophthalmol) Karger. 216 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Goto K.: "HLA and ocular diseases"Ocular Inflammation (Basic and Clinical Concepts) Martin Dunitz. 512 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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