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1999 Fiscal Year Final Research Report Summary

Distribution of race-specific null alleles of the FUT2 in Africa, European and Asian populations.

Research Project

Project/Area Number 10041209
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Human genetics
Research InstitutionDept. of Forensic Medicine, Kurume University School of Medicine

Principal Investigator

KIMURA Hiroshi  Kurume University, Dept. Forensic Med., Professor, 医学部, 教授 (20112039)

Co-Investigator(Kenkyū-buntansha) SOEJIMA Mikiko  Kurume University, Dept. Forensic Med., Instructor, 医学部, 助手 (80279140)
FUJITANI Noboru  Kurume University, Dept. Forensic Med., Associate Professor, 医学部, 助教授 (10156888)
KODA Toshiro  Kurume University, Dept. Forensic Med., Assistant Professor, 医学部, 講師 (90231307)
YUHUA Liu  Kurume University, Dept. Forensic Med., Instructor, 医学部, 助手 (30299515)
HAO Pang  Kurume University, Dept. Forensic Med., Instructor
Project Period (FY) 1998 – 1999
KeywordsABO / secretor / FUT2 / population / African / European / Asian
Research Abstract

The expression of ABO (H) antigens in secretions such as saliva is regulated by the Secretor gene (FUT2)-encoded α (1, 2) fucosyltransferase (Se enzyme). The ABO secretor group has at least one functional Se allele, and nonsecretors, who fail to express ABH antigens in saliva, are homozygous for the nonfunctional se allele. Our molecular analysis of the FUT2 in various population has suggested that null alleles were race-specific. The null allele seィイD1428ィエD1 was found to be common in African (Xhosa) and Caucasians (European and Iranian), while the null allele seィイD1357,385ィエD1 was found to be common in Asian populations (Chinese, Korean, Japanese, Indonesian an Samoan). Frequency of seィイD1428ィエD1 and of seィイD1375,385ィエD1 in each population was 0.4〜0.5. However, we found both seィイD1428ィエD1 and seィイD1375,385ィエD1 in a Bangladesh population. The presence of both seィイD1428ィエD1 (0.234) and seィイD1375,385ィエD1 (0.074) suggests the admixture of Aryans and Asians in Bangladesh. In addition, we found seィイD1fusィエD1 as one of null alleles in Japanese (0.05〜0.08) and the absence of the seィイD1fusィエD1 in Chinese, suggesting that the seィイD1fusィエD1 emerged from within Japanese.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Y. Liu, Y. Koda, M. Soejima, H. Pang. B. Wang, DS. Kim, HB. Oh, H. Kimura: "The fusion gene at the ABO-secretor locus(FUT2) : absence in Chinese populations"J Hum Genet. 44. 181-184 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H. Pang, Y. Koda, M. Soejima, T. Schlaphoff, ED du Toit, H. Kimura: "Allelic diversity of the human plasma α(1,3)fucosyltransferase gene(FUT6)"Ann Hum Genet. 63. 277-284 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y. Koda, Y. Watanabe, M. Soejima, H. Kimura: "Simple PCR detection of haptoglobin gene deletion in anhaptoglobinemic patients with antihaptoglobin antibody that causes anaphylactic transfusion"Bood. 95. 1138-1143 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y. Koda, M. Soejima, PH. Johnson, E. Smart, H. Kimura: "An Alu-mediated large deletion of the FUT2 gene in individuals with the ABO-Bombay phenotype"Hum Genet. 106. 80-85 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y. Liu, Y. Koda, M. Soejima, H. Pang, B. Wang, DS. Kim, HB. Oh, H. Kimura: "The fusion gene at the ABO-secretor locus (FUT2) : absence in Chinese populations."J Hum Genet.. 44. 181-184 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Pang, Y. Koda, M. Soejima, T. Schlaphoff, ED. Du Toit, H. Kimyra: "Allelic diversity of the human plasma α (1, 3) fucosyltranferase gene (FUT6)."Ann Hum Genet. 63. 277-284 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Koda, M. Soejima, PH. Johnson, E. Smart, H. Kimura: "An Alu-mediated large deletion of the FUT2 gene in individuals with the ABO-Bombay phenotype"Hum Genet.. 106. 80-85 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Pang, Y. Liu, Y. Koda, M. Soejima, JT. Jia, T. Schaphoff, ED. Du Toit, H. Kimura: "Five novel missense mutations of the Lewis gene (FUT3) in African (Xhosa) and Caucasian populations in South Africa."Hum Genet.. 102. 675-680 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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