1999 Fiscal Year Final Research Report Summary
Distribution of race-specific null alleles of the FUT2 in Africa, European and Asian populations.
| Project/Area Number |
10041209
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human genetics
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| Research Institution | Dept. of Forensic Medicine, Kurume University School of Medicine |
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Principal Investigator |
KIMURA Hiroshi Kurume University, Dept. Forensic Med., Professor, 医学部, 教授 (20112039)
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| Co-Investigator(Kenkyū-buntansha) |
SOEJIMA Mikiko Kurume University, Dept. Forensic Med., Instructor, 医学部, 助手 (80279140)
FUJITANI Noboru Kurume University, Dept. Forensic Med., Associate Professor, 医学部, 助教授 (10156888)
KODA Toshiro Kurume University, Dept. Forensic Med., Assistant Professor, 医学部, 講師 (90231307)
YUHUA Liu Kurume University, Dept. Forensic Med., Instructor, 医学部, 助手 (30299515)
HAO Pang Kurume University, Dept. Forensic Med., Instructor
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| Project Period (FY) |
1998 – 1999
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| Keywords | ABO / secretor / FUT2 / population / African / European / Asian |
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| Research Abstract |
The expression of ABO (H) antigens in secretions such as saliva is regulated by the Secretor gene (FUT2)-encoded α (1, 2) fucosyltransferase (Se enzyme). The ABO secretor group has at least one functional Se allele, and nonsecretors, who fail to express ABH antigens in saliva, are homozygous for the nonfunctional se allele. Our molecular analysis of the FUT2 in various population has suggested that null alleles were race-specific. The null allele seィイD1428ィエD1 was found to be common in African (Xhosa) and Caucasians (European and Iranian), while the null allele seィイD1357,385ィエD1 was found to be common in Asian populations (Chinese, Korean, Japanese, Indonesian an Samoan). Frequency of seィイD1428ィエD1 and of seィイD1375,385ィエD1 in each population was 0.4〜0.5. However, we found both seィイD1428ィエD1 and seィイD1375,385ィエD1 in a Bangladesh population. The presence of both seィイD1428ィエD1 (0.234) and seィイD1375,385ィエD1 (0.074) suggests the admixture of Aryans and Asians in Bangladesh. In addition, we found seィイD1fusィエD1 as one of null alleles in Japanese (0.05〜0.08) and the absence of the seィイD1fusィエD1 in Chinese, suggesting that the seィイD1fusィエD1 emerged from within Japanese.
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