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2000 Fiscal Year Final Research Report Summary

Joint Research on Micro Fluid Control System

Research Project

Project/Area Number 10044112
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Applied physics, general
Research InstitutionTohoku University

Principal Investigator

ESASHI Masayoshi  Tohoku University, New Industry Creation Hatchery Center, Professor, 未来科学技術共同研究センター, 教授 (20108468)

Co-Investigator(Kenkyū-buntansha) TANAKA Shuji  Tohoku University, Graduate School of Engineering, Research Associate, 大学院・工学研究科, 助手 (00312611)
HAGA Yoichi  Tohoku University, Graduate School of Engineering, Research Associate, 大学院・工学研究科, 助手 (00282096)
ONO Takahito  Tohoku University, Graduate School of Engineering, Lecturer, 大学院・工学研究科, 講師 (90282095)
MINAMI Kazuyuki  Tohoku University, Graduate School of Engineering, Lecturer, 大学院・工学研究科, 講師 (00229759)
LIU Lyong xun  Tohoku University, Graduate School of Engineering, Research Associate, 大学院・工学研究科, 助手 (90312610)
Project Period (FY) 1998 – 2000
KeywordsMicro fluid control / Micromachine / Micromachining / Biochemical analysis / Flow sensor / Valve / Pump / Molding
Research Abstract

Micro fluid control systems which have integrated flow sensors, valves, pumps and flow channels are needed for different applications. Silicon micromachining which can integrate sensors and signal processing circuits and micro molding for mass production of disposable plastic microstructures can be used to fabricate micro modules for micro fluid control systems.
Sampling module which uses surface tension for controlling the mixing of sample solution and reagent chemicals have been developed for chemical analyzing systems. Surface tension plays important roles in this system. To control hydrophobic properties of the surface, pulse co-electroplating of Teflon and nickel was successfully developed.
Micro molding technology has been studied for the mass-production of disposable plastic module for analyzing small volume blood sample. Micro molds were fabricated by deep reactive ion etching (RIE) of silicon or using numerically controlled high speed milling machine in Tohoku University and the molding by hot embossing was carried out in Friburg University in Germany which is the collaborator in this project. In addition, micro molding using UV curable resin and UV transparent silicone rubber mold were developed. Immuno-reaction chip which has micro colume has been also fabricated.
DNA chips which can be used for low cost parallel DNA diagnosis were developed by synthesizing different DNA probe photrolithographycally on a silicon chip. DNA chip for detecting SNP of cancer promoter is being developed based on the DNA chip. Spotting head for DNA chip was also fabricated.
Integrated mass flow controller for corrosive gases was developed for fine gas control in sophisticated semiconductor processes. Stainless steel and aluminum nitride are used as the materials because of their inertness to halogen gasses as fluoride and chloride.

  • Research Products

    (28 results)

All Other

All Publications (28 results)

  • [Publications] K.Hirata,D.Y.Sim and M.Esashi: "Delopment of an Anti-Corrosive Integrated Mass Flow controller"Technical Digest of the 17th Sensor Symposium. 17. 49-54 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Takahashi,K.Seio,M.Sekine and M.Esashi: "Study on DNA Chip Fabrication"Technical Digest of the 17th Sensor Symposium. 17. 89-94 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Hirata and M.Esashi: "Anti-Corrosive Integrated Mass-Flow Controller for Advanced Semiconductor Processes"Technical Digest of the 18th Sensor symposium . 18(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Sawa and M.Esashi: "Micromolding of disposable Polymer Parts for Medical Diagnostics"Technical Digest of the 18th Sensor Symposium. 18(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Takahashi,K.Sejo,M.Sekine and M.Esashi: "Fabrication of Directory Synthesized DNA Chip Using Photolithography for Rapid and Parallel Gene Analysis"Technical Digest of the Transducers'01. 11(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Abe and M.Esashi: "Ultrahydrophobic Surface Selectivity Modified by Pulse Electrodeposition from Aqueous Dispersion of PTFE Particles "Technical Digest of the Transducers'01. 11(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Hirata,D.Y.Sim and M.Esashi: "Stainless Steel-Based Integrated Mass-Flow Controller for Reactive and Corrosive Gases"Technical Digest of the Transducers'01. 11(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] R.U.Seidel,D.Y.Sim,W.Menz and M.Esashi: "A Capillary Force Filled Auto-mixing Device"Proc.of Intn.conf.on Microreaction Technology. 3. 40/1-2 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] R.U.Seidel,D.Y.Sim,W.Menz and M.Esashi: "Capillary Force Mixing Device as Sampling Module for Chemical Analysis"Technical Digest of the Transducers'99. 10. 438-441 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.G.Yu,D.Y.Sim,江刺正喜: "生化学合成用静電マイクロポンプの開発"電気学会センサ・マイクロマシン部門総合研究会資料. MM-99-32. 61-66 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] R.U.Seidel,D.Y.Sim,W.Menz and M.Esashi: "A New Approach to On-Site Liquid Analysis"Sensors and Materials. 12-2. 57-68 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Hirata,D.Y.Sim and M.Esashi: "Development of an Anti-Corrosive Integrated Mass Flow Controller"電気学会論文誌E. 120E-12,. 576-581 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小野崇人,芳賀洋一,高橋一憲,江刺正喜: "マイクロシステムとそのバイオへの応用"蛋白質核酸酵素. 45. 2542-2549 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] D.Y.Sim and M.Esashi: "Development of Inkjet Head for DNA Chip"Technical Digest of the 17th Sensor Symposium. 17. 437-442 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] R.U.Seidel, D.Y.Sim, W.Menz and M.Esashi: "A Capillary Force Filled Auto-mixing Device"Proc. of Intn. Conf. on Microreaction Technology. 3. 40/1-2 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] R.U.Seidel, D.Y.Sim, W.Menz and M.Esashi: "Capillary Force Mixing Device as Sampling Module for Chemical Analysis"Technical Digest of the Transducers' 99. 10. 438-441 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] R.U.Seidel, D.Y.Sim, W.Menz and M.Esashi: "A New Approach to On-Site Liquid Analysis"Sensors and Materials. 12-2. 57-68 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.G.Yu, D.Y.Sim and M.Esashi: "Electrostatic Micropump for Biochemical Synthesis"Technical Report IEEJ. MM-92-32(in Japanese). 61-66 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Hirata, D.Y.Sim and M.Esashi: "Development of an Anti-Corrosive Integrated Mass Flow Controller"The Transaction of The IEE of Japan. 120E-12. 576-581 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] D.Y.Sim and M.Esashi: "Development of Inkjet Head for DNA Chip"Technical Digest of the 17th Sensor Symposium. 17. 437-442 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Hirata, D.Y.Sin and M.Esashi: "Delopment of an Anti-Corrosive Integrated Mass Flow Controller"Technical Digest of the 17th Sensor Symposium. 17. 49-54 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Ono, Y.Haga, K.Takahashi and M.Esashi: "Microsystem and Its Application from Bioengineering"Protein, Nucleic Acid and Enzyme. 45-15(in Japanese). 2524-2549 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Takahashi, K.Seio, M.Sekine and M.Esashi: "Study on DNA Chip Fabrication"Technical Digest of the 17th Sensor Symposium. 17. 89-94 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Hirata and M.Esashi: "Anti-Corrosive Integrated Mass-Flow Controller for Advanced Semiconductor Processes"Technical Digest of the 18th Sensor Symposium. 18(in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Sawa and M.Esashi: "Micromolding of Disposable Polymer Parts for Medical Diagnostics"Technical Digest of the 18th Sensor Symposium. 18(in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Takahashi, K.Sejo, M.Sekine and M.Esashi: "Fabrication of Directory Synthesized DNA Chip Using Photolithography for Rapid and Parallel Gene Analysis"Technical Digest of the Transducers' 01. 11(in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Abe and M.Esashi: "Ultrahydrophobic Surface Selectivity Modified by Pulse Electrodeposition from Aqueous Dispersion of PTFE Particles"Technical Digest of the Transducers' 01. 11(in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Hirata, D.Y.Sim and M.Esashi: "Stainless Steel-Based Integrated Mass-Flow Controller for Reactive and Corrosive Gases"Technical Digest of the Transducers' 01. 11(in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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