2000 Fiscal Year Final Research Report Summary
Molecular mechanisms of pathogenicity of rinderpest virus
| Project/Area Number |
10044221
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| Research Category |
Grant-in-Aid for Scientific Research (A).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | Nippon Institute for Biological Science |
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Principal Investigator |
YAMANOUCHI Kazuya Nippon Inst. Biol. Sci., director, 主任研究員 (30072888)
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| Co-Investigator(Kenkyū-buntansha) |
NUNOYA Tetuo Nippon Inst. Biol. Sci., director Professor, 主任研究員 (80099994)
KAMATA Hiroshi Nihon Univ., Dept. Vet. Med., Associate, 生物資源科学部, 助教授 (30139050)
KAI Chieko Univ. Tokyo, Inst. Med. Sci., Professor, 医科学研究所, 教授 (10167330)
KOBUNE Fumiko Natl. Inst. Inf. Dis., Div. Biol., Chief, 室長 (80142644)
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| Project Period (FY) |
1998 – 2000
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| Keywords | Rinderpest / Pathogenicity / Reverse genetics / Immune mechanism / Recombinant vaccine |
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| Research Abstract |
System to recover infectious rinderpest virus (RPV) from cDNA copy of the virus genome was established on the RBOK strain of RPV, and role of virus gene in the pathogenicity was examined. The RBOK that is widely used as an attnuated vaccine does not show virulence in rabbits, whereas the L strain, another attenuated RPV, shows high virulence in rabbits. Involvement of the H gene in such difference in the susceptibility of rabbits was examined by construction chimeric RBOK virus containing the H gene of the RPV-L strain. The results indicate that not only the H gene but also the other genes may be involved in the expression of virulence in rabbits.
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