1999 Fiscal Year Final Research Report Summary
Virological and clinical study on HIV-2 infection.
| Project/Area Number |
10044253
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY |
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Principal Investigator |
KAGEYAMA Seiji Faculty of Medicine, TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY Associate Professor, 医学部, 助教授 (60252706)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAKI Kimiyasu Faculty of Medicine, TOYAMA MEDICAL AND PHARMACEUTICAL UNIVERSITY Professor, 医学部, 教授 (50135745)
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| Project Period (FY) |
1998 – 1999
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| Keywords | HIV-2 / HIV-1 / AIDS / Seronegative / replication / V3-loop |
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| Research Abstract |
Seronegative HIV-2 carriers have been found in India. Proviral HIV-2 was detected from 11 seronegative individuals for. HIV-1 and 2. Two HIV-2 strains were detected from the culture of peripheral blood mononuclear cells of two individuals among those. Those isolates belonged to subtype A. After the successful infection to immortalized T cells HIV-2 antigen in the cells was detected by anti-HIV-2 antibody. However, the antibody in the individual from whom HIV-2 was isolated could not be bound to the HIV-2 antigen. Those results imply the presence of HIV-2 in India.
The immune response to HIV-2 may act effectively. This may attributed to the fact that HIV-2 does not proliferate as much as HIV-1. Therefore immune evasion does not occur so often. As a result the amount of antigen was not enough to generate seroconversion in some cases. This was corroborated by the no alteration of amino acid sequence in V3-loop of HIV-2 during three years observation. Further careful observation is still on going to clarify the window period of HIV-2 infection as. The case of immune evasion is also focusing on as the future study.
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[Publications] Kageyama, S., Maniar, J. K., Iwasaki, M., Zhang, J., Saple, D. G., Tsuchie, H., Tanabe-Tochikura, A., Taniguchi, K., Shiraki, K., and Kurimura T.: "Seronegative HIV-2 carriers in India."Int J STD AIDS. 11(1). 31-37 (2000)
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