1999 Fiscal Year Annual Research Report

ヒトの随意運動に関する感覚運動連関の病態生理学的・無侵襲的研究

Research Project

Project/Area Number	10044269
Research Institution	KYOTO UNIVERSITY
Principal Investigator	柴崎浩京都大学, 大学院・医学研究科, 教授 (30037444)
Co-Investigator(Kenkyū-buntansha)	池田昭夫京都大学, 大学院・医学研究科, 助手 (90212761) 長峯隆京都大学, 大学院・医学研究科, 助手 (10231490) 福山秀直京都大学, 大学院・医学研究科, 助教授 (90181297)
Keywords	随意運動 / 感覚運動連関 / 無侵襲的研究 / 事象関連機能MR / 脳電位 / 脳磁図 / 補足運動野
Research Abstract	最終年度としての本年度は、各共同研究施設との間で得られた結果を総合的にまとめる一方、それぞれのプロジェクトを更に推進させた。 (1)全頭型脳磁図計を用いた研究健常者に随意的に運動開始、終止を行わせた場合の脳磁場変化および機能的MR画像を用いて本施設および米国NIHにおいて共同研究を行った。特に運動終了時において運動と反対側および同側の一次運動感覚野における背景活動の非同期化が顕著に認められた。また事象関連機能的MR画像の検討では、随意運動開始に比較して、運動終了時に内側前頭葉特に固有補足運動野および前補足運動野の局所脳血流の増加が認められ、これらの領域が陰性運動現象に深く関連することが示唆された。 (2)感覚運動連関に関する脳電図および硬膜下電極の記録健常者の選択課題によるCNVの脳電図記録とてんかん患者での硬膜下電極記録を当施設にて行い、その解析においてヘルシンキ工科大学との共同研究を推進した。その結果てんかん患者で慢性に留置された硬膜下電極からの記録では、随意的な手指の持続的筋収縮に伴なって、皮質脳波と表面筋電図の活動において17Hz前後を最大としたコヒーレンスを見い出すことができ、それは収縮する筋に対応する一次運動感覚野に限局していた。固有補足運動野と表面筋電図間のコヒーレンスも明らかとなった。さらに固有補足運動野と一次運動感覚野間のコヒーレンスの経時的変化を一過性の相性(phasic)筋収縮随意運動課題において検討し、後者より前者においてコヒーレンスの出現がより早期より出現した。また感覚運動連関に関する脳電図の変化に関しては、随伴陰性変動(CNV)課題において同様にてんかん患者での硬膜下電極記録を対象に解析を行っているが、緩電位変化と同様に、一次運動感覚野に加えて、運動前野および前頭前野の活動が示された。

Research Products

(16 results)

All Other

All Publications (16 results)

[Publications] Hanakawa T.et al.: "Enhanced lateral premotor activity during paradoxical gait in Parkinson's disease"Ann. Neurol.. 45. 329-336 (1999)
[Publications] Terada K.et al.: "Movement-related cortical potentials associated with voluntary relaxation of foot muscles"Clin. Neurophysiol.. 110. 397-403 (1999)
[Publications] Hamano T.et al.: "Abnormal contingent negative variation in writer's cramp"Clin. Neurophysiol.. 110. 508-515 (1999)
[Publications] Nishitani N.et al.: "Cortical visuomotor integration during eye pursuit and eye-finger pursuit"J. Neurosci.. 19. 2647-2657 (1999)
[Publications] Toma K.et al.: "Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation: an event-related fMRI study"J. Neurosci.. 19. 3527-3534 (1999)
[Publications] Ikeda A.et al.: "Cognitive motor control in human pre-supplementary motor area studied by subdural recording of discrimination/selection-related potentials"Brain. 122. 915-931 (1999)
[Publications] Mima T.et al.: "Somesthetic function of supplementary motor area during voluntary movements"Neuro Report. 10. 1859-1862 (1999)
[Publications] Hanakawa T.et al.: "Mechanisms underlying gait disturbance in Parkinson's disease.A single photon emission computed tomography study"Brain. 122. 1271-1282 (1999)
[Publications] Yazawa S.et al.: "Abnormal cortical processing of voluntary muscle relaxation in patients with focal hand dystonia studied by movement-related potentials"Brain. 122. 1357-1366 (1999)
[Publications] Shimizu H.et al.: "Pre-movement gating of short-latency somatosensory evoked potentials"Neuro Report. 10. 2457-2460 (1999)
[Publications] Mima T.et al.: "Brain structures related to active and passive finger movements in man"Brain. 122. 1989-1997 (1999)
[Publications] Kanada M.et al.: "Primary somatosensory cortex is actively involved in pain processing in human"Brain Res.. 853. 282-289 (2000)
[Publications] Murase N.et al.: "Abnormal premovement gating of somatosensory input in writer's cramp"Brain. (in press). (2000)
[Publications] Yazawa S.et al.: "Human pre-supplementary motor area is active before voluntary movement: subdural recording of Bereitschaftspotential from medial frontal cortex"Exp. Brain Res.. (in press). (2000)
[Publications] Ikeda A.et al.: "Role of primary sensorimotor cortices in generating inhibitory motor response in humans"Brain. (in press). (2000)
[Publications] Kunieda T.et al.: "Different actibation of pre-supplementary motor area (pre-SMA), SMA proper and primary sensori-motor area depending on the movement repetition rate in humans"Exp. Brain Res.. (in press). (2000)

1999 Fiscal Year Annual Research Report

ヒトの随意運動に関する感覚運動連関の病態生理学的・無侵襲的研究

Principal Investigator

柴崎 浩 京都大学, 大学院・医学研究科, 教授 (30037444)

Research Products

[Publications] Hanakawa T.et al.: "Enhanced lateral premotor activity during paradoxical gait in Parkinson's disease"Ann. Neurol.. 45. 329-336 (1999)

[Publications] Terada K.et al.: "Movement-related cortical potentials associated with voluntary relaxation of foot muscles"Clin. Neurophysiol.. 110. 397-403 (1999)

[Publications] Hamano T.et al.: "Abnormal contingent negative variation in writer's cramp"Clin. Neurophysiol.. 110. 508-515 (1999)

[Publications] Nishitani N.et al.: "Cortical visuomotor integration during eye pursuit and eye-finger pursuit"J. Neurosci.. 19. 2647-2657 (1999)

[Publications] Toma K.et al.: "Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation: an event-related fMRI study"J. Neurosci.. 19. 3527-3534 (1999)

[Publications] Ikeda A.et al.: "Cognitive motor control in human pre-supplementary motor area studied by subdural recording of discrimination/selection-related potentials"Brain. 122. 915-931 (1999)

[Publications] Mima T.et al.: "Somesthetic function of supplementary motor area during voluntary movements"Neuro Report. 10. 1859-1862 (1999)

[Publications] Hanakawa T.et al.: "Mechanisms underlying gait disturbance in Parkinson's disease.A single photon emission computed tomography study"Brain. 122. 1271-1282 (1999)

[Publications] Yazawa S.et al.: "Abnormal cortical processing of voluntary muscle relaxation in patients with focal hand dystonia studied by movement-related potentials"Brain. 122. 1357-1366 (1999)

[Publications] Shimizu H.et al.: "Pre-movement gating of short-latency somatosensory evoked potentials"Neuro Report. 10. 2457-2460 (1999)

[Publications] Mima T.et al.: "Brain structures related to active and passive finger movements in man"Brain. 122. 1989-1997 (1999)

[Publications] Kanada M.et al.: "Primary somatosensory cortex is actively involved in pain processing in human"Brain Res.. 853. 282-289 (2000)

[Publications] Murase N.et al.: "Abnormal premovement gating of somatosensory input in writer's cramp"Brain. (in press). (2000)

[Publications] Yazawa S.et al.: "Human pre-supplementary motor area is active before voluntary movement: subdural recording of Bereitschaftspotential from medial frontal cortex"Exp. Brain Res.. (in press). (2000)

[Publications] Ikeda A.et al.: "Role of primary sensorimotor cortices in generating inhibitory motor response in humans"Brain. (in press). (2000)

[Publications] Kunieda T.et al.: "Different actibation of pre-supplementary motor area (pre-SMA), SMA proper and primary sensori-motor area depending on the movement repetition rate in humans"Exp. Brain Res.. (in press). (2000)

柴崎浩京都大学, 大学院・医学研究科, 教授 (30037444)