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1999 Fiscal Year Final Research Report Summary

Noninvasive study of sensorimotor integration in human voluntary movements

Research Project

Project/Area Number 10044269
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

SHIBASAKI Hiroshi  Kyoto University, School of Medicine, Brain Pathophysiology, Professor, 医学研究科, 教授 (30037444)

Co-Investigator(Kenkyū-buntansha) IKEDA Akio  Kyoto University, School of Medicine, Brain Pathophysiology, Assistant Professor, 医学研究科, 助手 (90212761)
NAGAMINE Takashi  Kyoto University, School of Medicine, Brain Pathophysiology, Assistant Professor, 医学研究科, 助手 (10231490)
FUKUYAMA Hidenao  Kyoto University, School of Medicine, Brain Pathophysiology, Associate Professor, 医学研究科, 助教授 (90181297)
Project Period (FY) 1998 – 1999
Keywordsvoluntary movement / sensorimotor association / noninvasive study / event-related functional MRI / EEG / MEG / supplementary motor area
Research Abstract

During the last 2 years with this financial support, we obtained the new findings with special regard to the sensorimotor association in human motor control through international collaboration as follows.
(1) Study with functional MRI (fMRI) and positron emission tomography (PET)
Hemodynamic change was measured in association with voluntary muscle relaxation by means of single trial (event-related) fMRI analysis, and the increased activity was found in both primary and supplementary motor areas before the onset of muscle relaxation. There was a significantly greater increase in the mesial frontal area in the relaxation than in the contraction task. Cutaneous pain stimuli by laser beam elicited activation in the second somatosensory area and cingulate cortex as studied by means of fMRI, and in the primary somatosensory cortex by means of magnetoencephalography (MEG) and subdural EEG analysis.
(2) Whole head magnetoencephalography (MEG) study
Central processing mechanism in the sensory perception was investigated using electrical and auditory stimuli in order to clarify the effects of selective attention. It revealed that the early magnetic responses arising from the primary sensory cortices showed the significant changes in accordance with selective attention. We also clarified the cortical generator of P300 (auditory event-related potentials) noninvasively.
(3) EEG analysis in sensorimotor association
During continuous voluntary muscle contraction in humans, subdural EEG (ECoG) recorded from the primary motor area and EMG activity showed a high coherence mainly at 17 Hz frequency. In phasic voluntary muscle contraction, ECoGs from primary motor area and supplementary motor area proper showed a high coherence before muscle contraction.

  • Research Products

    (32 results)

All Other

All Publications (32 results)

  • [Publications] Hanakawa,T., et al.: "Enhanced lateral premotor activity during paradoxical gait in Parkinson's disease"Ann. Neurol.. 45. 329-36 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Terada,K. et al.: "Movement-related cortical potential associated with voluntary relaxation of foot muscles"Clin. Neurophysiol.. 110. 397-403 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hamano,T. et al.: "Abnormal contingent negative variation in writer's cramp"Clin. Neurophysiol.. 110. 508-15 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nishitani,N. et al.: "Cortical visuomotor integration during eye pursuit and eye-finger pursuit"J. Neurosci.. 19. 1647-57 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Toma,K. et al.: "Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation: an event-related fMRI study"J. Neurosci.. 19. 3527-34 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikeda,A. et al.: "Cognitive motor control in human pre-supplementary motor area studied by subdural recording of discrimination/selection-related potentials"Brain. 122. 915-31 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mima,T. et al.: "Somesthetic function of supplementary motor area during voluntary movements"NeuroReport. 10. 1859-62 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hanakawa,T. et al.: "Mechanisms underlying gait disturbance in Parkinson's disease. A single photon emission computed tomography study"Brain. 122. 1271-82 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yazawa,S. et al.: "Abnormal cortical processing of voluntary muscle relaxation in patients with focal hand dystonia studied by movement-related potentials"Brain. 122. 1357-66 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimizu,H. et al.: "Pre-movement fating of short-latency somatosensory evoked potentials"NeuroReport. 10. 2457-60 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mima,T. et al.: "Brain structures related to active and passive finger movements in man"Brain. 122. 1989-97 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kanda,M. et al.: "Primary somatosensory cortex is actively involved in pain processing in human"Brain Res.. 853. 282-9 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murase,N. et al.: "Abnormal premovement gating of somatosensory input in writer's cramp"Brain. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yazawa,S. et al.: "Human pre-supplementary motor area is active before voluntary movement: subdural recording of Bereitschaftspotential from medial frontal cortex"Exp. Brain Res.. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ikeda,A. et al.: "Role of primary sensorimotor cortices in generating inhibitory motor response in humans"Brain. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kunieda,T. et al.: "Different activation of pre-supplementary motor area (pre-SMA), SMA proper and primary sensori-motor area depending on the movement repetition rate in humans"Exp. Brain Res.. (in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hanakawa, T. et al.: "Enhanced lateral premotor activity during paradoxical gait in Parkinson's disease."Ann. Neurol.. 45. 329-36 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Terada, K. et al.: "Movement-related cortical potentials associated with voluntary relaxation of foot muscles."Clin. Neurophysiol.. 110. 397-403 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hamano, T. et al.: "Abnormal contingent negative variation in writer's cramp."Clin. Neurophysiol.. 110. 508-15 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nishitani, N. et al.: "Cortical visuomotor integration during eye pursuit and eye-finger pursuit."J. Neurosci.. 19. 2647-57 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Toma, K., et al.: "Activities of the primary and supplementary motor areas increase in preparation and execution of voluntary muscle relaxation : an event-related fMRI study."J. Neurosci. 19. 3527-34 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ikeda, A., et al.: "Cognitive motor control in human pre-supplementary motor area studied by subdural recording of discrimination/selection-related potentials."Brain. 122. 915-31 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mima, T. et al.: "Somesthetic function of supplementary motor area during voluntary movements."NeuroReport. 10. 1859-62 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hanakawa, T. et al.: "Mechanisms underlying gait disturbance in Parkinson's disease. A single photon emission computed tomography study."Brain. 122. 1271-82 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yazawa, S. et al.: "Abnormal cortical processing of voluntary muscle relaxation in patients with focal hand dystonia studied by movement-related potentials."Brain. 122. 1357-66 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimazu, H. et al.: "Pre-movement gating of short-latency somatosensory evoked potentials."NeuroReport. 10. 2457-60 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mima, T., et al.: "Brain structures related to active and passive finger movements in man."Brain. 122. 1989-97 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kanda, M., et al.: "Primary somatosensory cortex is actively involved in pain processing in human."Brain Res.. 853. 282-289 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murase, N., et al.: "Abnormal premovement gating of somatosensory input in writer's cramp."Brain. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yazawa, S. et al.: "Human pre-supplementary motor area is active before voluntary movement : subdural recording of Bereitschaftspotential from medial frontal cortex."Exp. Brain Res.. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ikeda, A. et al.: "Role of primary sensorimotor cortices in generating inhibitory motor response in humans."Brain. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kunieda, T. et al.: "Different activation of pre-supplementary motor area (pre-SMA), SMA proper and primary sensori-motor area depending on the movement repetition rate in humans."Exp. Brain Res.. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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