2002 Fiscal Year Final Research Report Summary
Structural Biology of Biological Machineries through X-ray Protein Crystallography Reinforced by Synchrotron Radiation
| Project/Area Number |
10188101
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo (1999-2003)
Nagaoka University of Technology (1998) |
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Principal Investigator |
TANOKURA Masaru Graduate School of Agricultural and Life Sciences, Professor, 大学院・農学生命科学研究科, 教授 (60136786)
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| Co-Investigator(Kenkyū-buntansha) |
TSUKIHARA Tomitake Osaka Univ., Protein Research Institute, Professor, 蛋白質研究所, 教授 (00032277)
MIURA Kinichiro Gakushuin Univ., Faculty of Sciences, Professor, 理学部, 教授 (30000227)
EBASHI Setsuro National Institute for Physiology, Emeritus professor, 生理研, 名誉教授 (10009863)
TANAKA Isao Hokkaido Univ., Graduate School of Science, Professor, 大学院・理学研究科, 教授 (70093052)
MIKI Kunio Kyoto Univ., Graduate School of Science, Professor, 大学院・理学研究科, 教授 (10116105)
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| Project Period (FY) |
1998 – 2003
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| Keywords | Biological machineries / Synchrotron radiation / Structural biology / X-ray crystallography / Complex of biomacromolecules / Group of biomacromolecules / membrane proteins |
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| Research Abstract |
This scientific research on priority areas of structural biology of biological machineries started 1) to set a forum of crystallographers with biochemists and molecular biologists, 2) to develop the crystallographic tools to utilize highly the synchrotron radiation facilities in our country that are the best ones in the world, 3) .to make a framework for structural biology of biological machineries, the word indicating the complexes or groups of several biological macromolecules that work for individual biological functions, in our country from both hardware and software. We have held five times of workshops and four times of symposia, and also have published newsletters from No.1 through 9, to facilitate the collaborations and exchange. As a result, many collaborations of crystallographers with biochemists and molecular biologists have been produced and hence many structures of proteins and other biological macromolecules (more than 200) have been determined and many papers (more than 900) have been published in this scientific research area on priority areas. We have also held many symposia and workshops in the annual meetings of Protein Society of Japan, Biophysical Society of Japan, Japan Biochemical Society, Japan Society for Molecular Biology, and so on Thus, we have succeeded in developing the structural biology of biological machineries, but structural biology of proteins and protein complexes become more and more important.
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[Publications] Iwasaki, W., Sasaki, H., Nakamura, A., Kohama, K., Tanokura, M.: "Metal-free and Ca^<2+>-bound structures of a multidomain EF-hand protein, CBP40,from the lower eukaryote, Physarum polycephalum"Structure. 11・1. 75-85 (2003)
Description
「研究成果報告書概要(和文)」より
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[Publications] Yasutake, Y., Watanabe, S., Yao, M., Tanaka, Y., Fukunaga, N., Tanaka, I.: "Structural of the Monomeric Isocitrate Dehydrogenase : Evidence of a Protein Monomerization by a Domain Duplication"Structure. 10. 1637-1648 (2002)
Description
「研究成果報告書概要(和文)」より
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[Publications] Ose, T., Watanabe, K., Mie, T., Honma, M.Watanabe, H., Yao, M., Oikawa, H., Tanaka, I.: "Insight into a natural Diels-Alder reaction from the structure of macrouhomate svnthase"Nature. 422. 185-189 (2003)
Description
「研究成果報告書概要(和文)」より
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[Publications] Kita, A., Matsunaga, S., Takai, A., Kataiwa, H., Wakimoto, T., Fusetani, N., Isobe, M., Miki, K.: "Crystal Structure of the Complex between Calyculin A and the Catalytic Subunit of Protein Phosuhatase 1"Structure. 10. 715-724 (2002)
Description
「研究成果報告書概要(和文)」より
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[Publications] Unno, M., Mizushima, T., Morimoto, Y., Tomisugi, Y., Tanaka, K., Yasuoka, N., Tsukihara, T.: "The Structure of the Mammalian 20S Proteasome at 2.75 A Resolution"Structure. 10. 609-618 (2002)
Description
「研究成果報告書概要(和文)」より
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[Publications] Iwasaki, W., Sasaki, H., Nakamura, A., Kohama K. and Tanokura, M.: "Metal-free and Ca^<2+> bound structures of a mutidomain EF-hand protein, CBP40, from the lower eukaryote, Physarum polycephalum"Structure. 11(1). 75-85 (2003)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Yasutake, Y., Watanabe, S., Yao, M., Takada, Y., Fukunaga, N. & Tanaka, I.: "Structural of the Monomeric Isocitrate Dehydrogenase : Evidence of a Protein Monomerization by a Domain Duplication"Structure. 10. 1637-1648 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Ose, T., Watanabe, K., Mie, T., Honma, M., Watanabe, H., Yao, M., Oikawa, H. & Tanaka, I.,: "Insight into a natural Diels-Alder reaction from the structure of macrophomate synthase"Nature. 422. 185-189 (2003)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Kita, A., Matsunaga, S., Takai, A., Kataiwa, H., Wakimoto, T., Fusetani, N., Isobe, M. & .Miki, K.: "Crystal Structure of the Complex between Calyculin A and the Catalytic Subunit of Protein Phosphatase 1"Structure. 10. 715-724 (2002)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Unno, M., Mizushima, T., Morimoto, Y., Tomisugi, Y., Tanaka, K., Yasuoka, N. & Tsukihara, T.: "The Structure of the Mammalian 20S Proteasome at 2.75 A Resolution"Structure. 10. 609-618 (2002)
Description
「研究成果報告書概要(欧文)」より
