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2000 Fiscal Year Final Research Report Summary

Analyses of stress responses and thier adaptation mechanisms of the body in special references to formation and removal systems of reactive oxigen species.

Research Project

Project/Area Number 10307009
Research Category

Grant-in-Aid for Scientific Research (A).

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionHirosaki University

Principal Investigator

SUGAWARA Kazuo  Hirosaki University, Hygiene, Sch.Med., Professor, 医学部, 教授 (80136788)

Project Period (FY) 1998 – 2000
Keywordsexercise / stress / neutrophils / monocytes / cytokines / interleukins / reactive oxigen species / antioxidants
Research Abstract

We firstly investigated the effects of exercise as a model of stress research, and demonstrated that exercise-induced neutrophil priming was attributed to the increased plasma concentrations of growth hormones, interleukins 6 and 8, and that although neutrophil priming was associated with muscle damage, these stress responses were acclimated by repetition or exercise. Furthermore, we demonstrated that neutrophil activation marker (myeloperoxidase and lactoferrin) increased in plasma and urine after marathon race and also revealed that phagocyte-priming substances such as growth hormone, prolactin, chemokines, colony-stimulating factors rose in plasma and urine. On the other hand, it was demonstrated that immunosuppressive substances such as cortisol and interleukin 10 also rose and antioxidant activity was increased in plasma after marathon race. Among the substances investigated, vitamin C was demonstrated to rise after the race, and this might work as an adaptation mechanisms against oxidative stress. In addition, although we investigated the effects of surgical operation as a model of stress, it was demonstrated that such an extreme stress inhibited neutrophil activity in spite of marked increases in circulating cytokines. Considered together, althogh neutrophils and monocytes are prone to release reactive oxygen species and proteolytic enzymes on exposure to stress because of the increased concentrations of several bioactive substances and consequently inflammation are induced, adaptation mechanisms such as mobilization of antioxidants exist . These findings suggest that supplementation of antioxidants such as vitamin C inhibit pathogenesis due to oxidative stress.

  • Research Products

    (18 results)

All Other

All Publications (18 results)

  • [Publications] 佐藤英樹 他: "非鍛錬者における持久性運動負荷および8週間のトレーニングが好中球活性酸素種産生能に及ぼす影響"日本衛生学雑誌. 53(2). 430-440 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 古家琢也 他: "インターフェロン-αのヒト好中球活性酸素種産生能に及ぼす影響"日本衛生学雑誌. 53(3). 536-544 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Qiang,Liu et al: "EFFECT OF NATURAL 9-CIS AND SYNTHETIC ALL-TRANS BETA-CAROTENES ON THE CHEMILUMINESCENCE RESPONSES OF HUMAN NEUTROPHILS"Journal of Physical Fitness, Nutrition and Immunology. 7(1). 57-63 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Qiang,Liu et al: "Effect of decaglycerol mono-oeate on chemiluminescnece of human neutrophils."Luminescence. 14. 327-330 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kenji Kowatari et al: "Applicabolity chemiluminescence to assess the degree of operative stress in patients undergoing spinal surgery."Luminescence. 14. 331-334 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Satoru Kudoh et al: "Contribution of nitric oxide synthethase to human neutrophil chemiluminescence."Luminescence . 14. 335-339 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Katsuhiko Suzuki et al: "Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics, and muscle damage."J.Appl.Physiol.. 87(4). 1360-1367 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki K et al: "Circulating cytokines and hormones with immunosuppressive but neutrophil-priming potentials rise after endurance exercise in humans."European Journal of Applied Physiology. 81. 281-287 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Suzuki K et al: "Exercise-induced humoral modulation of phagocytes by cytokines and antioxidants."Medicine and Science in Sports and Exercise (suppl.). (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hideki Sato et al: "Effect of acute endurance exercise and 8 week training on the production of reactive oxygen species from neutrophils in untrained man."Jpn.J.Hyg.. 53. 431-440 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takuya Koie et al: "The effects of interferon-α on oxygen radical production by human neutrophils."Jpn.J.Hyg.. 53. 536-544 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Qiang, Liu et al: "EFFECT OF NATURAL 9-CIS AND SYNTHETIC ALL-TRANS BETA-CAROTENES ON THE CHEMILUMINESCENCE RESPONSES OF HUMAN"Journal of Physical Fitness, Nutrition and Immunology. 7(1). 57-63 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Qiang, Liu et al: "Effect of decaglycerol mono-oeate on chemiluminescnece of human neutrophils."Luminescence. 14. 327-330 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kenji Kowatari et al: "Applicabolity chemiluminescence to assess the degree of operative stress in patients undergoing spinal surgery."Luminescence. 14. 331-334 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Satoru Kudoh et al: "Contribution of nitric oxide synthethase to human neutrophil chemiluminescence."Luminescence. 14. 335-339 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Katsuhiko Suzuki et al: "Endurance exercise causes interaction among stress hormones, cytokines, neutrophil dynamics, and muscle damage."J.Appl.Physiol.. 87(4). 1360-1367 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki K et al: "Circulating cytokines and hormones with immunosuppressive but neutrophil-priming potentials rise after endurance exercise in humans."European Journal of Applied Physiology. 81. 281-287 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Suzuki K et al: "Exercise-induced humoral modulation of phagocytes by cytokines and antioxidants."Medicine and Science in Sports and Exercise. (suppl.), (inpress).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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