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2000 Fiscal Year Final Research Report Summary

A study of a relation of umbilical cord occlusion to fetal brain damage by an artificial uterus

Research Project

Project/Area Number 10307025
Research Category

Grant-in-Aid for Scientific Research (A).

Allocation TypeSingle-year Grants
Section一般
Research Field Embryonic/Neonatal medicine
Research InstitutionUniversity of Tokyo

Principal Investigator

BABA Kazunori  University of Tokyo, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (30181035)

Co-Investigator(Kenkyū-buntansha) ABE Yusuke  University of Tokyo, Graduate School of Medicine, Associate Professor, 大学院・医学系研究科, 助教授 (90193010)
CHINZEI Tsuneo  University of Tokyo, Research Center for Advanced Science and Technology, Associate Professor, 先端科学技術研究センター, 助教授 (20197643)
KOZUMA Shiro  University of Tokyo, University Hospital, Associate Professor, 医学部・附属病院, 助教授 (10272569)
KIKUCHI Akihiko  University of Tokyo, University Hospital, Instructor, 医学部・附属病院, 助手 (10280942)
MARUMO Genzo  University of Tokyo, University Hospital, Instructor, 医学部・附属病院, 助手 (60282646)
Project Period (FY) 1998 – 2000
Keywordsfetal brain damage / PVL / umbilical cord occlusion
Research Abstract

Periventricular leukomalacia (PVL) is a major cause of cerebral palsy. However, pathogenetic mechanisms of PVL have not been fully understood. By using fetal sheep, we studied the contribution of umbilical cord occlusion to fetal brain damage, such as PVL.Fetal sheep underwent umbilical cord occlusion (3 minutes total cord occlusions, 5 times at 5 minutes intervals).
Dissections performed 24 h after cord occlusion revealed that various damages were produced in the fetal brain. According to the pattern of brain damage, we classified the fetal sheep into three groups : fetuses with dominant lesions in the periventricular white matter (group A), fetuses with brain lesions in the cerebral cortex and thalamus (group B) and fetuses with no or minimal brain lesions (group C). Group A showed higher blood pressure and higher plasma lipid peroxide levels before cord occlusion compared to the other groups, while group B showed systemic hypotension during cord occlusion. No significant differences in changes in pH, PaCO2, PaO2 and heart rate were found between the three groups. It was speculated that PVL might be produced by an association of preexisting chronic circulatory instability with an acute episode of severe repetitive cord occlusion. And the results of the immunohistochemical study suggested the glial reaction of cytokines and free radicals induced by fetal hypoxia might contribute to the occurrence of brain damage.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Marumo G,Kozuma S,Baba K, et al: "Generation of periventricular leukomalacia by repeated umbilical cord occlusion in near-term fetal sheep and its possible pathogenetical mechanisms"Biol Neonate. 79・1. 39-45 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 花田信継,上妻志郎 他: "羊臍帯圧迫に伴う虚血再灌流におけるNOの関与に関する検討"日本産科婦人科学会雑誌. 52・2. 455 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohyu J,Marumo G,Baba K, et al: "Early axonal and glial pathology in fetal sheep brains with leukomalacia induced by repeated umbilical cord occlusion"Brain Dev. 21・4. 248-252 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 上妻志郎: "臍帯圧迫によるPVL発症モデルの開発"日本新生児学会雑誌. 35・4. 705-706 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kozuma S,Unno N,Baba K, et al: "Goal fetuses disconnected from the placenta, but reconnected to an artificial placenta, display intermittent breathing movements"Biol Neonate. 75・6. 388-397 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 丸茂元三,上妻志郎,馬場一憲 他: "臍帯圧迫による胎児中枢神経細胞障害"周産期学シンポジウム. 16. 37-41 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Marumo G, Kozuma S, Baba K, et al.: "Generation of periventricular leukomalacia by repeated umbilical cord occlusion in near-term fetal sheep and its possible pathogenetical mechanisms."Biol Neonate. 79(1). 39-45 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hanada N, Kozuma S, et al.: "A role of NO in reperfusion after umbilical cord occlusion in fetal sheep"Acta Obst Gynaec Jap. 52(2). 455 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohyu J, Marumo G, Baba K, et al.: "Early axonal and glial pathology in fetal sheep brains with leukomalacia induced by repeated umbilical cord occlusion"Brain Dev. 21(4). 248-252 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kozuma S: "Development of an animal model with PVL by umbilical cord occlusion"Acta Neonat Jpn. 35(4). 705-706 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kozuma S, Unno N, Baba K, et al.: "Goat fetuses disconnected from the placenta, but reconnected to an artificial placenta, display intermittent breathing movements"Biol Neonate. 75(6). 388-397 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Marumo G, Kozuma S, Baba K, et al.: "Fetal central nervous system damage by umbilical cord occlusion"Year Book of Japan Society of Perinatology. 16. 37-41 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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