2001 Fiscal Year Final Research Report Summary
Stress states and psychobiological stress respones: Experimental-field study
| Project/Area Number |
10410027
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
実験系心理学
|
|---|
| Research Institution | Kurume University |
|---|
Principal Investigator |
TSUDA Akira Kurume University. Professor, 文学部, 教授 (40150817)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TSUDA Shigeko Kurume University. Associate Professor, 文学部, 講師 (20197700)
YAMADA Shigeto Saga Medical University. Professor, 医学部, 教授 (20158190)
|
|---|
| Project Period (FY) |
1998 – 2000
|
| Keywords | Psychobiological stress response / perceived stress / saliva level of free 3-methoxy-4-hydroxyphenyleglycol(MHPG) / anxiety disorder / anxiolytic drug / experimental-field study / mood / anxiety |
|---|
| Research Abstract |
The modern transactional theories of stress and coping address that psychobiological stress responses emerge through an imbalance between demands (i.e., stressors) and psychosocial coping resources. This study is to examine the relationship among stress responsiveness, cognition, emotion and performance under acute and/or chronic stressful situations using the experimental-field paradigm.
1.As a measure of the levels of anxiety, mood, perceived stress in normal volunteers, we determined the saliva level of free 3-methoxy-4-hydroxyphenyleglycol (MHPG), using gas chromatography-mass spectrometry. The saliva level of free-MHPG was significantly correlated with score of tension-anxiety, depression and symptoms of stress in male, but not in female.
2.We measured free MHPG levels in the saliva and scored the levels of anxiety with Hamilton Anxiety Scale in anxious outpatients, before and after drug treatment with anxiolytic drugs such as alprazolam and tandospirone for 1 week. The saliva level of free-MHPG was significantly reduced by alppazolam treatment.
These findings suggest that the free Saliva MHPG level may be a useful indicators for assessing not only the level of perceived stress, but also the response to drug treatment for anxiety in anxious patients.
|
