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2000 Fiscal Year Final Research Report Summary

Construction and Function of Supramolecular polvmers

Research Project

Project/Area Number 10450350
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field 高分子合成
Research InstitutionTokyo Institute of Technology

Principal Investigator

UENO Akihiko  Tokyo Institute of Technology, Graduate School of Bioscience and Biotechnology, Professor, 大学院・生命理工学研究科, 教授 (50091658)

Co-Investigator(Kenkyū-buntansha) IKEDA Hiroshi  Tokyo Institute of Technology, Assistant Professor, 大学院・生命理工学研究科, 助手 (70201910)
MIHARA Misakazu  Tokyo Institute of Technology, Associated Professor, 大学院・生命理工学研究科, 助教授 (30183966)
Project Period (FY) 1998 – 2000
Keywordscyclodextrin / polymer / fluorescence / rotaxane / naphthalene / energy transfer / ant nn
Research Abstract

The main object of this study is construction of polyrotaxanes composed of cyclodextrin (CD) and modified CD as a novel copolymers, in which monomer units are connected together not by covalent bond but by supramolecular interaction. From this viewpoint, we prepared a series of polyrotaxanes, which have α-CD and naphthtalene-modified α-CD (NpCD) as monomer units and a poly (ethylene glycol) as a threading chain. The ratios of the NpCD unit in the polyrotaxanes are 20%, 60%, and 100 % when both ends of poly (ethylene glycol) have anthracene units as stoppers. We examined energy transfer from naphthalene units to anthracene units in the systems, in which naphthalene units may be expected to act as antenna units which absorb light. Light harvesting ability of the systems increased but energy transfer efficiency from the naphthalene units to anthracene ones decreased with increasing content of naphthalene unit in the polyrotaxane series. This system also revealed that fluorescence anisotropy decreases with increasing content of NpCD in the polyrotaxanes, informing that energy migration occurs and energy tends to be lost during the randomly occurring energy transfer. We also constructed another type of polyrotaxanes, in which trinitrophenyl units exist at both ends. We observed quenching of the naphthalene fluorescence in various solvent systems with different polarities and found that highly efficient energy transfer is attained in the solvent system of low polarity and antenna effect becomes remarkable with increasing content of naphthalene unit in the polyrotaxanes.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] M.Akhter Hossain et al.: "Association and Guest-induced Dissociation of a Novel α-Helix Peptide Boaring Pyrene and γ-Cyclodextrin in the Side chains"Chem.Lett.. 252-253 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M,Tamura and A.Ueno: "Energy Transfer and Guest Responsive Fluoresconce Spectra of Polyrotaxane Consisting of α-Cyclodextrins Bearing Naphthyl Moieties"Bull.Chem.Soc.Jpn. 73. 147-154 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Woo-Sang Lie and A,Ueno: "A New Feature of Bifunctional Catalysis, Cyclodextrins Boaring Two Imidazole Moletios as Hydrolysis Enzyme Model"Chem.Lett.. 258-259 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] I,Kumagal et al.: "Construction of HIV Rev Peptides Containing Peptide Nucleic Acid That Bind HIV PRE IIB RNA"Bioorganic & Medicinal Chem, Lett.. 10. 377-379 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S,Matsumura et al.: "Construction of α-Helix Peptides with β-Cyclodextrin and Dansyl Units and Their Conformational and Molecule Sensing Properties"Chem.Eur.J.. 6. 1781-1788 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H,Tsutsumi et al.: "Rate Enhancement and Enantioselectivity in Ester Hydrolysis Catalyzed by Cyclodextrin-peptide Hybrids"J, Chem.Soc., Perkin Trans 2. 1813-1818 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Tamura, D.Gao, A.Ueno: "A Polyrotaxane Series Containing α -Cyclodextrin and Naphthalene-Modified α -Cyclodextrin as a Light-Harvesting Antenna System"Chem. Eur. J.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Hamasaki, R.Suzuki, H.Mihara, A.Ueno: "Remarkable Stabilization of the α -Helix Structure by an Intramolecular Host-Guest Bridge in a Cyclodextrin-Peptide Hybrid"Macromol. Rapid Commun.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] W-S.Lee, A Ueno: "Photocontrol of the Catalytic Activity of a β -Cyclodextrin Bearing Azobenzene and Histidine Moieties as a Pendant Group"Macromol. Rapid Commun.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Aoyagi, H.Ikeda, A.Ueno: "Fluorescence Properties, Induced-Fit Guest Binding and Molecular Recognition Abilities of Modified γ -Cyclodextrins Bearing Two Pyrene Moieties"Bull. Chem. Soc.Jpn.. 74. 157-164 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.Matsumura, S.Sakamoto A.Ueno, H.Mihara: "Construction of α-Helix Peptides with β-Cyclodextrin and Dansyl Units and Their Conformational and Molecular Sensing Properties"Chem. Eur. J.. 6. 1781-1788 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Tsutsumi, K.Hamasaki, H.Mihara, A.Ueno: "Cyclodextrin-Peptide Hybrid as a Hydrolytic Catalyst Having Multiple Functional Groups"Bioorg. Med. Chem. Lett.. 10. 741-744 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Tamura, A.Ueno: "Energy Transfer and Guest Responsive Fluorescence Spectra of Polyrotaxane Consisting of α-Cyclodextrins Bearing Naphthyl Moieties"Bull. Chem. Soc. Jpn.. 73. 147-154 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.A.Hossain, K.Hamasaki, H.Mihara, A.Ueno: "Association and Guest-Induced Dissociation of a Novel α-Helix Peptide Bearing Pyrene and γ-Cyclodextrin in the Side Chain"Chem. Lett.. 252-253 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] W-S.Lee, A.Ueno: "A New Feature of Bifunctional Catalysis. Cyclodextrins Bearing Two Imidazole Moieties as Hydrolysis Enzyme Model"Chem. Lett.. 258-259 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.A.Hossain, S.Matsumura, T.Kanai, K.Hamasaki, H.Mihara, A.Ueno: "Association of α-Helix Peptides That Have γ-Cyclodextrin in the Side Chain, and Induction of Dissociation of the Association Dimer by External Stimulant"J.Chem. Soc., Perkin Trans.. 2. 1527-1533 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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