2000 Fiscal Year Final Research Report Summary
Functional maps in the central nervous system concerning the regulation of body temperature
| Project/Area Number |
10470016
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental physiology (including Physical medicine and Nutritional physiology)
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| Research Institution | Kyoto Institute of Technology |
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Principal Investigator |
TOSHIKAZU Kivohara Kyoto Institute of Technology, Faculty of Textile Science, Professor, 繊維学部, 教授 (50071874)
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| Co-Investigator(Kenkyū-buntansha) |
TOSHIHIRO Nakashima Graduate School of Science and Technology, Associate Professor, 工芸科学研究科, 助教授 (30128136)
SEIJI Miyata Graduate School of Science and Technology, Research Associate, 工芸科学研究科, 助手 (30243124)
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| Project Period (FY) |
1998 – 2000
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| Keywords | temperature / body temperature / central nervous system / environment / Fos / cold acclimination / LPS / vasopressin |
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| Research Abstract |
It has been well not known for the neural circuits for the regulation of body temperature and the adaptation mechanisms to cold and warm environments in the central nervous system. In this research project, we focused on the expression of Fos protein, a functional neuronal marker or protooncogene product, and then examined the neural circuits for the regulation of body temperature in the central nervous system.
1) The mechanism of cold acclimination in the central nervous system using Fos immunohistochemistry.
When infant mammalians were exposed to cold environment, they accliminate to cold environment even in adult. Therefore, we examined how the neuronal circuits are changed to adapt to cold environment. The infant rats were exposed to cold (4℃) for 2 hr during two weeks after birth, and then the expression of Fos in the central nervous system was investigated when they grow to adult. The number of Fos-positive neurons was significantly lower in the some hypothalamic regions, whereas the number was not different from non-treated control ones. This result suggest that the cold acclimination to cold environment is due to the alteration of neuronal plasticity in the hypothalamus.
2) LPS-induced increases in body temperature and activation of oxytocin and vasopressin neurons.
Bacterial lipopolysaccharides (LPS) are well known to induce the increases of body temperature. However, how oxytocin and vasopressin neurons are concerned with this process is not well elucidated. In this project, we examined the activation of oxytocin and vasopressin neurons after the body temperature increase with LPS using Fos immunohistochemistry. Intraperitoneal or intravenous administration of LPS induced significant increases in Fos expression of oxytocin and vasopressin neurons. This result suggest that oxytocin and vaspressin are important for LPS-dependent body temperature increase possibly by regulating the contraction of blood vessels and water homeostasis.
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[Journal Article] Metabolic map of the rat brains in pregnant, parturient and lacatating females using Fos immunohistochemistry2007
Author(s)
Lin, S-H., Miyata, S., Matsunaga, W., Kawarabayashi, T., Nakashima, T., Kiyohara, T.
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Journal Title
Brain Research 787
Pages: 226-236
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Comparison of the expression of two immediate-early gene proteins, FosB and Fos in the rat preoptic area, hypothalamus and brain stem during pregnancy, parturition and lactation.2007
Author(s)
Lin, S-H., Miyata, S., Weng, W., Matsunaga, W., Ichikawa, J., Furuya, K., Nakashima, T., Kiyohara, T.
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Journal Title
Neuroscience Research 32
Pages: 333-341
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Microtubule-associated protein2 (MAP2) in hypothalamo-neurohypophysial system : low molecular weight MAP2 in pituitary astrocytes.2007
Author(s)
Matsunaga, W., Miyata, S., Hashimoto, Y., Lin-S-H., Nakashima, T., Kiyohara, T., Matsumoto, T.
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Journal Title
Neuroscience 88
Pages: 1289-1297
Description
「研究成果報告書概要(和文)」より
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[Journal Article] LPS-induced Fos expression in oxytocin and vasopressin neurons in rat hypothalamus.2000
Author(s)
Matsunaga, W., Miyata, S., Takamata, R., Bun, H., Nakashima, T., Kiyohara, T.
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Journal Title
Brain Research 858
Pages: 9-18
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Expression of the IgLON cell adhesion molecules Kilon and OBCAM in hypothalamic magnocellular neurons.2000
Author(s)
Miyata, S., Funatsu, N., Matsunaga, W., Kiyohara, T., Sokawa, Y., Maekawa, S.
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Journal Title
Journal of Comparative Neurology 424
Pages: 74-85
Description
「研究成果報告書概要(和文)」より
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[Journal Article] Changes in the localization of NAP-22, a novel calmodulin binding membrane protein, during the development of neuronal polarity.2000
Author(s)
Kashihara, M., Miyata, S., Matsunaga, W., Kiyohara, T., Sokawa, Y., Maekawa, S.
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Journal Title
Neuroscience Research 37
Pages: 315-326
Description
「研究成果報告書概要(和文)」より
-
-
[Journal Article] Metabolic map of the rat brains in pregnant, parturient and lacatating females using Fos immunohistochemistry
Author(s)
Lin, S-H., Miyata, S., Matsunaga, W, Kawarabayashi, T., Nakashima, T., Kiyohara, T.
-
Journal Title
Brain Research (1998) 787
Pages: 333-341
Description
「研究成果報告書概要(欧文)」より
-
-
-
[Journal Article] Comparison of the expression of two immediate-early gene proteins, FosB and Fos in the rat preoptic area, hypothalamus and brain stem during pregnancy, parturition and lactation.
Author(s)
Lin, S-H., Miyata, S., Weng, W., Matsunaga, W, Ichikawa, J., Furuya, K., Nakashima, T., Kiyohara, T.
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Journal Title
Neuroscience Research (1998) 32
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Microtubule-associated protein2 (MAP2) in hypothalamo-neurohypophysial system : low molecular weight MAP2 in pituitary astrocytes.
Author(s)
Matsunaga, W., Miyata, S., Hashimoto, Y., Lin-S-H., Nakashima, T., Kiyohara, T., Matsumoto, T.
-
Journal Title
Neuroscience (1999) 88
Pages: 1289-1297
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
[Journal Article] LPS-induced Fos expression in oxytocin and vasopressin neurons in rat hypothalamus.
Author(s)
Matsunaga, W, Miyata, S., Takamata, R., Bun, H., Nakashima, T., Kiyohara, T.
-
Journal Title
Brain Research (2000) 858
Pages: 918
Description
「研究成果報告書概要(欧文)」より
-
-
[Journal Article] Expression of the IgLON cell adhesion molecules Kilon and OBCAM in hypothalamic magnocellular neurons.
Author(s)
Miyata, S., Funatsu, N., Matsunaga, W., Kiyohara, T., Sokawa, Y., Maekawa, S.
-
Journal Title
Journal of Comparative Neurology (2000) 424
Pages: 74-85
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Changes in the localization of NAP-22, a novel calmodulin binding membrane protein, during the development of neuronal polarity.
Author(s)
Kashihara, M., Miyata, S., Matsunaga, W., Kiyohara, T., Sokawa, Y., Maekawa, S.
-
Journal Title
Neuroscience Research (2000) 37
Pages: 315-326
Description
「研究成果報告書概要(欧文)」より
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