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2000 Fiscal Year Final Research Report Summary

Central control mechanisms of calcium homeostasis and its physiological significance

Research Project

Project/Area Number 10470017
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionKYUSHU UNIVERSITY

Principal Investigator

AOU Shuji  KYUSHU UNIVERSITY, Grad.Sch.Med., Ass.Prof., 大学院・医学研究院, 助教授 (40150908)

Co-Investigator(Kenkyū-buntansha) TAKE Sachiko  KYUSHU UNIVERSITY, Grad.Sch.Med., Res.Assoc., 大学院・医学研究院, 助手 (80253425)
TAKAKI Atsushi  KYUSHU UNIVERSITY, Grad.Sch.Med., Res.Associ., 大学院・医学研究院, 助手 (30243934)
HORI Tetsuro  Kyushu University, Emeritus Prof., 名誉教授 (00022814)
Project Period (FY) 1998 – 2000
Keywordslateral hypothalamic area / paraventricular nucleus / ventromedial nucleus / calcium metabolism / obesity / hypocalcemia / stress / kearning
Research Abstract

1) Calcium is deeply involved in adaptive control of behaviors and relevant homeostatic function during environmental changes. One of the calcium regulating brain loci, the lateral hypothalamic area, produce orexins. Orexin-A suppressed spatial learning and long-term potentiation, while facilitated avoidance learning. The peptide showed analgesic action.
2) Endogenous sugar acid 2-buten-4-olide, a satiety substance, facilitated the spatial memory. The pretreatment of acidic fibroblast growth factor antibody eliminated the effect of 2-buten-4-olide both during the training sessions and the probe test.
3) Cholecystokinin (CCK) is one of the potent hypocalcemic factor. CCK-A receptor gene deficient Otsuka Long Evans Tokushima Fatty (OLETF) rats showed spatial memory deficits and abnormal emotionality. Active fragment of aFGF improved the performance of the spatial memory task in OLETF rats.
4) The leptin receptor deficient animals, Zucker rats and db/db/mice who have abnormality in bone metabolism, showed impaired LTP and spatial memory.
5) Bisphenol A and tributyltin induced a disruption of the sexual differentiation in the locus coeruleus and learning behavior without affecting the reproductive function into the lateral hypothalamic area also induced hypokalemia which was blocked by nadrol and ranitidine.
These findings strongly suggest that the hypothalamus play an important role in adaptive control of not only calcium metabolism and other visceral functions but also learning, memory and emotion.

  • Research Products

    (78 results)

All Other

All Publications (78 results)

  • [Publications] Kamikawa,H.: "IL-1β increases norepinephrine level in rat frontal cortex : involvement of prostanoids, NO and glutamate."Am.J.Physiol.. 275. 803-810 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hori,T: "Pain modulatory actions of cytokines and PGE2 in the brain."Ann.New York Acad.Sci.. 840. 269-281 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Karadi,Z: "Complex functional attributes of amygdaloid gustatory neurons in the rhesus monkey"Ann.New York Acad.Sci.. 855. 488-492 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hori,T: "Cell biology and the functions of thermosensitive neurons in the brain.in Brain Function in Hot Environment : Basic and Clinical Perspectives."Progress in Brain Research. 115. 9-23 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Li,A-J.: Neuroscience. 85. 785-794 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Oka,K.: "PGE2 receptor subtype EP1 antagonist may inhibit central interleukin-1 β-induced in rats."Am.J.Physiol.. 275. 1762-1765 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "情動の脳科学"心療内科. 2. 429-434 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 堀哲郎: "脳-免疫系連関と伝達物質"Clinical Neuroscience. 16. 73-75 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 堀哲郎: "脳・免疫系連関に関する最近の進歩"老年精神医学雑誌. 9・11. 1381-1392 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 堀哲郎: "神経系内分泌系と免疫系との相互作用"免疫・Immunology Frontier. 8・6. 333-341 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "食欲のしくみ"婦人之友. 92. 104-109 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "ここまでわかった食欲不振の病態生理."Journal of Integrated Medicine (JIM). 8. 638-641 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Woody CD: "Identification of differently timed motor components of conditioned blink responses."Brain Research. 836. 79-89 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "摂食行動の基礎"心身医学. 39. 99-109 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "食欲の生理・生化学"からだの科学. 207. 28-34 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 李学良: "OLETFラットの学習障害と[Ala]16-aFGF(1-29)による改善"OLETFラット研究会記録集. 最終卷. 101-104 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Li,A-J: "Protective effect of acidic fibroblast growth factor against ischemia-induced learning and memory deficits in two tasks in gerbils."Physiol.& Behav.. 66(4). 577-583 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hosoi,M: "Prostaglandin E2 has antinociceptive effect through EP1 receptor in the ventrom〓al hypothalamus in rats."Pain. 82. 221-227 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kamikawa,H: "Hyperalgesic response to noxious stimulation in genetically polydipsic mice."Brain Res.. 846. 171-176 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 堀哲郎: "神経・内分泌・免疫連関"アレルギー・免疫. 6. 52-61 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 堀哲郎: "情動と免疫"Clinical Neuroscience. 48(7). 772-775 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hori,T.: "Evidence for th einvolvement of AV3V in the circulating IL-β-to-brain communication."Journal of Thermal Biology. 25. 29-33 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hori,T.: "Hypothalamic mechanisms of pain modulatory actions of cytokines and prostaglandin E2."Ann.N.Y.Acad.Sci.. 106-120 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Araishi,K: "Loss of the sarcoglycan complex and sarcospan leads to muscular dystrophyn in b-sarcogycan-deficient mice.."Human Molecular Genetics. 8. 1589-1598 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ogata R.: "Two-generation reproductive toxicity study of tributyltin chloride in female rats."Journal of Toxicology and Environmental Health. (印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "摂食障害と脳腸シグナル"消化器心身医学. 7. 42-49 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "個体維持・種族保存のための中枢多重共調節系と環境因子"環境と健康. 13. 128-141 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "有機スズの二世代長期曝露のラット行動に及ぼす影響"Biomed.Res.Trace Elements. 11. 253-258 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "摂食調節と脳"BME(医用電子と生体工学)誌. 14. 21-28 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "森林浴はなぜ身体によいのか"Clinical Neuroscience. 18. 1344 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "満腹中枢および摂食中枢の局在と機能連関"日本臨床. (印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "概論:食欲と摂食行動の生理学"日本臨床. (印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "みどりの香りの生理作用と効用"Aroma Research(臨時増刊号). (印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Chen L.: "Cytological characterization of a pituitary folliculo-stellate-like cell line, Tpit/F1, with special reference to adenosine triphospate-mediated neuronal nitric oxide synthase expression and nirric oxide secretion"Endocrinology. 141. 3603-3610 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Jimbo H.: "Fata severe vasospasm due to rewarming following hypothermia-case report-."Neurol Med Chir ^*Tokyo. 40. 463-466 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sudo N.: "Dietary nucleic acid promote a shift in Th1/Th2 balance tward Th-1 dominant immunity."Clinical Exp.Allergy. 30. 979-987 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Katafuchi,T.: "Impairment of spatial learning and hippocampal synaptic potentiation in c-kit mutant rats."Learning & Memory. 7. 383-392 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hori,T.: "Evidence for th einvolvement of AV3V in the circulating IL-β-to-brain communication."Journal of Thermal Biology. 25. 29-33 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Katafuchi,T.: "Changes in brain cytokine mRNA due to heat stress in aged rats : possible role of bacterial translocation."Progress in Biometeorology. (印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 堀哲郎: "IL-6"Clincal Neuroscience. 19(6)(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takaki,A.: "Brain and Biodefence"Japan Scientific Societies Press. 248 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "摂食障害"日本評論社. 156 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Li,A,-J.: "Brain and Biodefence"Japan Scientific Societies Press. 248 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Oka,T.: "Cytokines and Pain"Birkhaeuser Publishing Ltd, Basel. 225 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "心理学辞典"有斐閣. 290 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "心身医学用語辞典"医学書院. 1086 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Aou,S.: "Thermotherapy : Principle and Practice-Application and neoplasia, Inflammation, and Pain."Springer-Verlag Tokyo. 550 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takaki,A: "Control Mechanisms of Stress and Emotion : Neuroendocrine-Based Studies"Elsevier Science B.V. 248 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hori,T. et al.: "Thermotherapy for Neoplasia, Inflammation and Pain"Springer-Verlag Tokyo Inc.. 550 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "21世紀の健康と医生物学第2巻 環境を生かす"昭和堂(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "情動と生理.心身医学標準テキスト・第2版"医学書院(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 粟生修司: "認知科学辞典(分担)"共立出版(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hori,T.: "Psychoneuroimmunology"Academic Press. 727 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kamikawa, H., Hori, T., Nakane, H., Aou, S., and Tashiro, N.: "IL-1 β increases norepinephrine level in rat frontal cortex : involvement of prostanoids, NO, and glutamate."Am J Physiol. 275. R803-R810 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hori, T., Oka, T., Hosoi, M.& Aou, S.: "Pain modulatory actions of cytokines and PGE2 in the brain."Ann. New York Acad.Sci.. 840. 269-281 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Karadi, Z., Scott, T.R., Oomura, Y., Nishino, H., Aou, S., and Lenard, L.: "Complex functional attributes of amygdaloid gustatory neurons in the rhesus monkey."Ann NY Acad Sci. 855. 488-492 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hori T & Katafuchi T: "Cell biology and the functions of thermosensitive neurons in the brain."Progress in Brain Research (edited by Sharma H.S & Westman J). 115. 9-23 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Li, A.-J., Oomura, Y., Sasaki, K., Suzuki, K., Tooyama, I., Hanai, K., Kimura, H.and Hori, T.: "A single pre-training glucose injection induces memory facilitation in rodents performing various tasks : contribution of acidic fibroblast growth factor."Neuroscience. 85. 785-794 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oka K, Oka T, & Hori T: "PGE2 receptor subtype EP1 antagonist may inhibit central interleukin-1b-induced fever in rats."Am J Physiol. 275. R1762-1765 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takaki, A., Shioda, S., Ito, K., Maeda, M., Kanemitsu, Y., Yagi, S., Arimura, A.& Hori, T.: "Non-inflammatory stress and brain-gut-liver-immune axis."In : Brain and Biodefence (Eds.Oomura, Y.& Hori, T) Japan Scientific Societies Press, Tokyo/Karger, Basel. 155-160 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Li A-J, Oomura Y, Sasaki K, Hori N, Tooyama I, Nomura Y, Hanai K, Kimura H, Yanaihara N, Yoshii H, Yamazaki Y, Take S & Hori T: "(1998) Action of aFGF in senescence-accelerated mice : protective effects against deficits of learning and memory, and effects on immunological functions."In : Brain and Biodefence (edited by Oomura Y & Hori T) Japan Scientific Societies Press Tokyo/Karger Basel. 51-61 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oka T & Hori T: Brain cytokines and pain. In : Cytokine and Pain (edited by Watkins L.R.and Maier S.F.) Birkhauser Verlag Basel. 183-203 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Woody CD., Aou S.: "Identification of differently timed motor components of conditioned blink responses."Brain Research.. 836(1-2). 79-89 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Li, A-J, Oomura, Y., Sasaki, K., Suzuki, K.& Hori, T.: "Protective effect of acidic fibroblast growth factor against ischemia-induced learning and memory deficits in two tasks in gerbils."Physiol.& Behav.. 66(4). 577-583 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hosoi, M., Oka, T., Abe, M., Hori, T., Yamamoto, H., Mine, K.& Kubo, C.: "Prostaglandin E2 has antinociceptive effect through EP1 receptor in the ventromedial hypothalamus in rats."Pain. 82. 221-227 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kamikawa, H., Katafuchi, T., Hosoi, M., Yamamoto, T.& Hori, T.: "Hyperalgesic response to noxious stimulation in genetically polydipsic mice."Brain Res.. 846. 171-176 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Araishi, K., Sasaoka, T., Imamura, M., Noguchi, S., Hama, H., Wakabayashi, E., Yoshida, M., Hori, T.& Ozawa, E.: "Loss of the sarcoglycan complex and sarcospan leads to muscular dystrophyin β-sarcoglycan-deficient mice."Human Molecular Genetics. 8. 1589-1598 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takaki, A., Hori, T., Yagi, S., Oka, K., Kanemitsu, Y., Sudo, N., Shioda, S.& Arimura, A.: "Plasma IL-6 and its pyrogenicity during noninflammatory stress."In : Control Mechanisms of Stress and Emotion : Neuroendocrine-Based Studies. (Eds.Yamashita, H., Funder, J.W., Verbalis, J.G., Ueta, Y.& Endo, Y.) Elsevier Science B.V., Amsterdam, The Netherlands. 173-177 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hori, T., Oka, T., Hosoi, M., Abe, M.& Oka, K.: "Hypothalamic mechanisms of pain modulatory actions of cytokines and prostaglandin E2."Ann.N.Y.Acad.Sci.. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hori, T., Katafuchi, T., Ota, K., Matsuda, T., Oka, T.& Oka, K.: "Evidence for the involvement of AV3V in the circulating IL-1β-to-brain communication."J.Thermal.Biol.. 25. 29-33 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Aou S, Li X-L, Kubo K, Oomura Y and Hori T: "Thermoregulation as survival mechanism in individuals and species : mutual control of body temperature, ingestion and reproduction in the hypothalamus."In : Thermotherapy : principles and Practice-Applications in Neoplasia, Inflammation, and Pain-(Eds.Kosaka M, Sugihara T, Schmidt KL, Simon E) 63-67, Springer-Verlag Tokyo. (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] L.Chen, A.Takaki, K.Inoue et al.: "Cytological characterization of a pituitary folliculo-stellate-like cell line, Tpit/F1, with special reference to adenosine triphospate-mediated neuronal nitric oxide synthase expression and nitric oxide secretion."Endocrinology.. 141. 3603-3610 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Jimbo, K.Dohi, A.Takaki, et al.: "Fata severe vasospasm due to rewarming following hypothermia-case report-."Neurol Med Chir ^*Tokyo. 40. 463-466 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Sudo, A.Takaki, C.Kubo et al.: "Dietary nucleic acid promote a shift in Th1/Th2 balance tward Th-1 dominant immunity."Clinical Exp.Allergy. Vol.30. 979-987 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hori, T., Katafuchi, T., Ota, K., Matsuda, T., Oka, T.& Oka, K.: "Evidence for the involvement of AV3V in the circulating IL-1β-to-brain communication."J.Thermal.Biol.. 25. 29-33 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Katafuchi, T., Li, A-J., Hirota, S., Kitamura, Y.and Hori, T.: "Impairment of spatial learning and hippocampal synaptic potentiation in c-kit mutant rats."Learn Mem.. 7. 383-392 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hori, T., Katafuchi, T.& Oka, T.: "Central cytokines : effects on peripheral immunity, inflammation and nociception."In : Psychoneuroimmunology, Third Edition, (Eds.Ader, R., Felten, D.L.& Cohen, N) Academic Press. 517-545 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ogata R, Omura M, Shimasaki Y, Kubo K, Oshima Y, Aou S, Inoue N: "(2000) Two-generation reproductive toxicity study of tributyltin chloride in female rats."Journal of Toxicology and Environmental Health.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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