2001 Fiscal Year Final Research Report Summary
Effect of concomitant exposure of endocrine disrupting chemicals and its risk assessment
| Project/Area Number |
10470096
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
MAKITA Yuji Kyushu University, Faculty of Medicine Associate Professor, 大学院・医学研究院, 助教授 (30209407)
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| Co-Investigator(Kenkyū-buntansha) |
OMURA Minoru Kyushu University, Faculty of Medicine Assistant, 大学院・医学研究院, 助手 (50243936)
HIRATA Miyuki Kyushu University, Faculty of Medicine Assistant, 大学院・医学研究院, 助手 (30156674)
TANAKA Akiyo Kyushu University, Faculty of Medicine Assistant Professor, 大学院・医学研究院, 講師 (10136484)
INOUE Naohide Kyushu University, Faculty of Medicine Professor, 大学院・医学研究院, 教授 (00131904)
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| Project Period (FY) |
1998 – 2000
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| Keywords | Edocrine disrupter / P,p'-DDE / Tributyltin(TBT) / Combined effect / Wistar rat / アンドローゲン作用 / 抗アンドローゲン作用 / 哺乳動物 |
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| Research Abstract |
P,p'-DDE(DDE) and tributyltin (TBT)have been ubiquitous in the environment and are suspected to be potent endocrine disrupters. DDE and TBT are considerably taken in Japan from marine products, in which they are included through bio-concentration and food chain. Above all, fetuses and neonates are highly susceptible to endocrine disrupters and faced with concurrent exposure of DDE and TBT through the maternal environment, where these substances are much contained in increased marine product intake during pregnancy and in milk during nursing period. Therefore, the combined effects of DDE and TBT on rat offspring were investigated by simultaneous administration of DDE and/or TBT in pregnant Wistar rats. In this study, TBT did suppress the growth and reduce the prostate weight of rat offspring, whereas DDE itself scarcely affected but restored the growth suppression and prostate weight reduction by TBT. These results indicate that TBT could affect the endocrine system of rat male offspring as well as that of marine prosobranch snails and suggest that TBT may exert its actions through the androgen receptor as DDE is known to be an androgen receptor antagonist in rats.
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