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2000 Fiscal Year Final Research Report Summary

Study on Minimum-effective Dosage for Improvement of Intestinal Environment and Maximum Non-effective Dosage for transitory Diarrhea of Non-digestible and/or Non-absorbable Saccharide Sweeteners.

Research Project

Project/Area Number 10470104
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionSiebold University of Nagasaki (1999-2000)
The University of Tokyo (1998)

Principal Investigator

OKU Tsuneyuki  Department of Nursing and Nutrition, Siebold University of Nagasaki Professor, 看護栄養学部, 教授 (50010096)

Project Period (FY) 1998 – 2000
KeywordsNon-digestible and / or non-absorbable saccharides / Minimum-effective dosage / Maximum Non-effective dosage / Digestion, fermentation, absorption / Oligosaccharides / Sugar alcohols / Breath hydrogen / Diarrhea
Research Abstract

The final goal of this study is to find the effective utilization of functional foods containinz non-disestible and/or non-absorbable sugar substitutes for the health promotion, clarifying minimum-effective dosage for improvement of intestinal environment, maximum non-effective dosage for transitory diarrhea of these saccharides, and the concerning factors such as dividing ingestion, adaptation, combination of sugar substitutes etc.. The results obtained were as follows :
(1) The maximum non-effective dosage for transitory diarrhea of trehalose, lactulose and galactosyl-sucrose were indicated for adult Japanese.
(2) The 2 or 3 divided ingestion of galactosyl-sucrose increased the maximum non-effective dosage to 2-folds.
(3) The 10-days repeated ingestion of chocolate containing lactitol increased the maximum non-effective dosage to 1.5-folds. Namely, it is clearly established that the adaptation to sugar substitute increase the maximum non-effective dosage for transitory diarrhea.
(4) The combined ingestion of sugarless chocolate containing lactitol and soft drink containing polydextrose caused diarrhea, though chocolate ingestion alone was not.
(5) The intestinal trehalase activity of Japanese was separated to 2 groups of lower and higher from the results of maximum non-effective dosage using trehalose and lactulose. The person with lower activity did not stimulate the secretion of insulin.
(6) Breath hydrogen excretion was the least in erythritol and the most in sorbitol in a monosaccharide alcohols group and the results were reasonable for the absorbability of them. That of disaccharide alcohols, maltitol and lactitol, were more than that of sorbitol. The breath hydrogen excretion by oligosaccharide ingestion was in order isomalto-oligosaccharide, galactosyl-sucrose and fructo-oligosaccharide, and it was demonstrated isomalto-oligosaccahride is readily digested by digestive enzymes.

  • Research Products

    (21 results)

All Other

All Publications (21 results)

  • [Publications] 奥恒行: "人を対象とした難消化性糖質含有食品の有効性ならびに許容量試験のデザインとポイント."日本食品新素材研究会誌. 4(印刷中). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsuneyuki Oku,Sadako Nakamura: "Estimation of intestinal trehalase activity from a laxative threshold of trehalose and lactulose on healthy subjects."European Journal of Clinical Nutrition. 54. 783-788 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 奥恒行,岡松洋,藤井康弘: "ビーグル犬の便重量および消化管通過時間に及ぼすポリデキストロースの影響"日本食物繊維研究会誌. 4. 29-35 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 奥恒行,中村禎子: "低分子化アルギン酸ナトリウム含有コーンポタジュの便重量ならびに便性状の改善効果."Progress in Medicine. 20. 2063-2071 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 奥恒行,岡崎光子: "人における難消化性オリゴ糖・ガラクトシルスクロースの一括摂取と分割摂取の一過性下痢誘発に及ぼす影響ならびにその許容量."日本栄養・食糧学会誌. 52. 201-208 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsuneyuki Oku,Sunja Kwon.: "Disaccharidase activity in rat cecum and colon with hyperplasia induced by maltitol and glucomannan."Journal Nutritional Science and Vitaminology. 44. 69-78 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 奥恒行,中村禎子,岡崎光子: "低分子化アルギン酸ナトリウムの排便および便性に対する改善効果と有効量."栄養学雑誌. 56. 89-99 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsuneyuki Oku,Mitsuko Okazaki: "Transitory laxative threshold of treh alose and lactulose in healthy women."Journal Nutritional Science and Vitaminology. 44. 787-798 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsuneyuki: "OkuNewly developed sugar substitutes and their functions in foods."Proceeding of the 2nd Asian Congress of Dietetics (in, August 9-12 Seoul, Korea,). 220-227 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 奥恒行: "低エネルギー性糖質甘味料・エリスリトールの体内代謝と食品への応用."栄養学雑誌. 56. 189-198 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Oku T.: "Design and point in estimation expriments of functionality and maximum non-effective dose on Nondigestible saccharides containing processing foods in human subjects.(in Japanese)"J.Japan.Coun.Adv.Food Ingred.ares.. 4 (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oku T., Nakamura S.: "Estimation of intestinal trehalase activity from a laxative threshold o trehalose and lactulose on healthy subjects."Eur.J.Clin.Nutr.. 54. 783-788 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oku T., Nakamura S.: "Effects of partially hydrolyzed sodium alginate-containing corn potage on fecal weight and conditions in normal subjects.(in Japanese)"Progress in Medicine. 20. 2063-2071 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oku T., Okamatsu H., Fujii Y.: "Effect of polydextrose on fecal weight and gastrointestinal transit time in beagle dogs.(in Japanese)"J.Japan.Soc.Dietary Fiber Res.. 4. 29-35 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oku T., Okazaki M.: "Effect of single and divided ingestions of the nondigestible oligosaccharide "galactosyl-sucrose" on trarusitory diarrhea and laxative threshold in normal female subjects (in Japanese)"J.Nutr.Sci.Vitaminol. 44. 787-798 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oku T., Kwon S.: "Disaccharidase activity in rat cecum and colon with hyperplasia induced by maltitol and glucomannan."J.Nutr.Sci.Vitaminol. 44. 787-798 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oku T., Nakamura S., Okazaki M.: "Effect of partially hydrolyzed sodium alginic acid on defecation and fecal conditions.(in Japanese)"Japan.J.Nutr.. 56. 89-99 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oku T., Okazaki M.: "Transitory laxative threshold of trehalose and lactulose jn healthy women."J.Nutr.Sci.Vitaminol. 44. 787-798 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oku T.: "Newly developped sugar substitutes and their functions in foods."Proceeding of the 2nd Asian Congress of Dietetics. August 9-12, (1998), Seoul, Korea.. 220-227 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oku T.: "Beneficial health effects of nondigestibleJ.oligosaccharides and water-soluble dietary fiber.(in Japanese)"Japan, Coun.Adv.. 4 (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oku T., Nakamura S., Okazaki M.: "Study on the laxative threshold of sugarless chocolate."(in preparation).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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