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2000 Fiscal Year Final Research Report Summary

Molecular Mechanism and Blood Flow Imaging of the Formation of Angioarchitech titure during the Occurrence and Progression of Hepatocellular Carcinoma.

Research Project

Project/Area Number 10470143
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Gastroenterology
Research InstitutionKinki University School of Medicine

Principal Investigator

KUDO Masatoshi  Kinki University School of Medicine, Department of Gastroenterology and Hepatology, Professor and Chairman, 医学部・附属病院 (10298953)

Project Period (FY) 1998 – 2000
Keywordshepatocellular carcinoma / tumor vessel / tumor neovascularization / hemodynamics / multicenter occurrence / harmonic imaging / angioarchitecture / angiogenic factor
Research Abstract

1. Change of Intranodular Blood Flow During the Occurrence and Multistep Progression of Hepatocellular Carcinoma.
Hepatocellular carcinoma(HCC)occurs as a hyperplastic nodule at its initiation of cancer. During multistep progression, hyperplastic nodule develops to the early well-differentiated HCC, and finally to advanced moderately differentiated HCC.Consistent with this progression, intranodular hemodynamic also changes, from arterially hypovascular and portally iso-perfusion(type I)to hypoperfusion state both from artery and portal vein(type II). Then it develops to the isovascular(type III)and to the classical hypervascular HCC(type II). This alteration can be detected by in vivo vascular imagings, such as US angiography, CTA, and CTAP.
2. Hemodynamic Analysis
In addition to invasive vascular imaging, contrast harmonic imaging with intravenous injection of ultrasound contrast agent is extremely useful in the detection of intra nodular vascularity, both arterial and portal venous flow.

  • Research Products

    (59 results)

All Other

All Publications (59 results)

  • [Publications] Kudo M: "Morphological diagnosis of hepalocellular carcinoma : special emphais on intranodular hemodynamic imaging."Hepato-Gastroenterology. 45. 1226-1231 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamamoto T, Kudo M, et al.: "Hepatocellular carcinomas intected with the novel TT DNA virus lack viral integration."Biochem Bioph Res Co. 251. 339-343 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kim SR, Kudo M, et al.: "A case of well-differentiated minute hepatocellular carcinoma with extrahepatic metastasis."J Gastroenterol Hepatol. 13. 892-896 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Watanabe T, Kudo M, et al.: "Detection of Helicobacter Pylori gene using immunomagnetic separation based PCR from feces."Scand J Gastroenterol. 11. 1140-1143 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tochi H, Kudo M, et al.: "Association between a focal spared area in the fatty liver and intrahepatic efferent blood flow from the gallbladder wall"AJR. 172. 1249-1253 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamamoto T, Kudo M, et al.: "Determination of the clonal origin of multiple human hepatocellular carcinomas by cloning and polymerase chain reaction of the integrated hepatitis Bvirus DNA."Hepatology. 29. 1446-1452 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kudo M: "Liver Radiological Examination- Ultrasonography (including Biopsy), In "Abdominal and Gastrointestinal Imaging Multimedia Virtual Textbook", Gourtsoyioannis NE."Medic-Online, Euromiltimedia S.A, Luxembourg. (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Marusawa H, Kudo M, et al.: "High prevalence of hepatitis B virus serological markers in patients. with hepatitis C virus related chronic liver disease in Japan."Gut. 45. 284-288 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kudo M: "Imaging diagnosis of hepatocellular carcinoma and premalignant/borderline lesions."Seminors in Liver Disease. 19. 297-309 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Watanabe T, Kudo M, et al.: "Cronkhite-Canada syndrome associated with triple gastric cancers : report of a case."Gastrointest Endoscopy. 50. 688-691 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Watanabe T, Kudo M, et al.: "Massive rectal bleeding due to ileal tuberculosis."J Gastroenterol. 34. 525-529 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kim SR, Kudo M, et al.: "Intlammatory pseudotumor of the liver in patient with chronic hepatitis C : Difficulty in differentiating it from hepatocellular carcinoma."Pathology International. 49. 726-730 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kudo M: "Riedel's lobe of the liver and its clinical implications."Internal Medicine. 39(2). 87-88 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kim SR, Kudo M, et al.: "A case of hepatocellular carcinoma transforming from adenomatous hyperplasia in three years with the background of non-B non-C, non-TTV chronic persistent hepatitis."Intervirology. 43(7). 13-15 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakaoka R, Kudo M, et al.: "Repeated hepatic arterial chemoembolization therapy for management of a patient with metastatic carcinoid tumors of the liver."Am J Gastroenterol. 95(7). 1842-1843 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kim SR, Kudo M, et al.: "Hepatocellular carcinoma transforming from dysplastic nodule with background of non-B non-C chronic persistent hepatitis."Journal of Hepatology. 33. 857-858 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nomura H, Kudo M, et al.: "Laparoscopic splenopexy for adult wandering spleen : Sandwich method with two sheets absorbable knitted mesh."Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. 10(5). 332-334 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kudo M: "Hepatocellular adenoma in type Ia glycogen storage disease."J Gastroenterol. 36. 65-66 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ding H, Kudo M, et al.: "Contrast-enhanced subtraction harmonic sonography for evaluating treatment response in patients with hepatpcellular carcinoma."AJR. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawasaki T,Kudo M, et al.: "Vascularity of advanced gastric carcinoma : evaluation by using power Doppler imaging."J Gastroenterol Hepatol. 16(in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimu SR, Kudo M, et al.: "A case of disseminated extrahepatic carcinoma after US-guided biopsy and percutaneous ethanol injection therapy."Hepatology Research. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawasaki T,Kudo M, et al.: "A case of localized primary sclerosing cholangitis mimicking interahepatic bile duct cancer."Hepatology Research. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ding H, Kudo M, et al.: "Detection of tumor parenchymal flow in hepatocellular carcinoma : utility of intermittent harmonic imaging in the early arterial phase with dual display mode."Radiology. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ding H, Kudo M, et al.: "Diagnosis of pancreatic islet cell tumor : value of intermittent harmonic imaging."JCU. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kudo M: "Hepatic peribiliary cysts : clinically harmless disease with potential risk due to increase in size and number."J Gastroenterol. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kudo M: "Cerebral vascular resistence in hepatic insufficiency."J Gastroenterol Hepatol. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kudo M: "Blood flow characteristics and hepatocellular carcinoma."Oncology. (in press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kudo M: "Advances in diagnostic imaging of the hepatocellular carcinoma. In "Hepatology in the 21st Century : Diagnosis and Therapy.""IASL, APASL, and JSH JOINT POST GRADUATE TEXTBOOK. 9 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kudo M: "Color Doppler observation of efferent blood flow in liver tumors. In Dynamic Study of Efferent Tumor Blood Fow"BRACCO, Italy, 2001 (in Press). (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kudo M: "Morphological diagnosis of hepatocellular carcinoma : special emphasis on intranodular hemodynamic imaging"Hepato-Gastroenterology. 45. 1226-1231 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamamoto T, Kudo M, et al: "Hepatocellular carcinomas infected with the novel TT DNA virus lack viral integration."Biochem Bioph Res Co. 251. 339-343 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kim SR, Kudo M, et al: "A case of well-differentiated minute hepatocellular carcinoma with extrahepatic metastasis."J Gastroenterol Hepatol. 13. 892-896 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe T, Kudo M, et al: "Detection of Helicobacter Pylori gene using immunomagnetic separation based PCR from feces."Scand J Gastroenterol. 11. 1140-1143 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tochio H, Kudo M, et al: "Association between a focal spared area in the fatty liver and intrahepatic efferent blood flow from the gallbladder wall : evaluation by color Doppler sonography."AJR. 172. 1249-1253 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamamoto T, Kudo M, et al: "Determination of the clonal origin of multiple human hepatocellular carcinomas by cloning and polymerase chain reaction of the integrated hepatitis B virus DNA."Hepatology. 29. 1446-1452 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kudo M: "Liver Radiological Examination- Ultrasonography(including Biopsy)"In "Abdominal and Gastrointestinal Imaging Multimedia Virtual Textbook", Gourtsoyiannis NE, Yamada R, Itai Y, Meyers M, Nolan D, Ros P, Stevenson G, eds., Medic-Online, Euromultimedia S.A., Luxembourg. (http : //medic-online.net). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Marusawa H, Kudo M, et al: "High prevalence of hepatitis B virus serological markers in patients with hepatitis C virus related chronic liver disease in Japan."Gut. 45. 284-288 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kudo M: "Imaging diagnosis of hepatocellular carcinoma and premalignant/borderline lesions."Seminors in Liver Disease. 19. 297-309 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe T, Kudo M, et al: "Cronkhite-Canada syndrome with triple gastric cancers : report of a case."Gastrointest Endoscopy. 50. 688-691 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe T, Kudo M, et al: "Massive rectal bleeding due to ileal tuberculosis."J Gastroenterol. 34. 525-529 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kim SR, Kudo M, et al: "Inflammatory pseudotumor of the liver in patient with chronic hepatitis C : Difficulty in differentiating it from hepatocellular carcinoma."Pathology International. 49. 726-730 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kudo M: "Riedel's lobe of the liver and its clinical implications."Internal Medicine. 39(2). 87-88 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kim SR, Kudo M, et al: "A case of hepatocellular carcinoma transforming from adenomatous hyperplasia in three year with the background of non-B non-C, non-TTV chronic persistent hepatitis."Intervirology. 43(7). 13-15 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kudo M: "Advances in diagnostic imaging of hepatocellular carcinoma. In "Hepatology in the 21st Century : Diagnosis and Therapy." Tanikawa K, Kojiro M, Gollan J, eds."IASL, APASL, and JSH JOINT POST GRADUATE TEXTBOOK, IASL Publ, Fukuoka, 2000. 43-51 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakaoka R, Kudo M, et al: "Repeatted hepatic arterial chemoembolization therapy for management of a patient with metastatic carcinoid tumors of the liver."Am J Gastroenterol. 95(7). 1842-1843 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kim SR, Kudo M, et al: "Hepatocellular carcinoma transforming from dysplastic nodule with background of non-B non-C chronic persistent hepatitis."Journal of Hepatology. 33. 857-858 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nomura H, Kudo M, et al: "Laparoscopic splenopexy for adult wandering spleen : Sandwich method with two sheets of absorbable knitted mesh."Surgical Laparoscopy, Endoscopy & Percutaneous Techniques. 10(5). 332-334 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kudo M: "Hepatocellular adenoma in type Ia glycogen storage disease."J Gastroenterol. 36. 65-66 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ding H, Kudo M, et al: "Contrast-enhanced subtraction harmonic sonography for evaluating treatment response in patients with hepatpcellular carcinoma."AJR. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawasaki T, Kudo M, et al: "Vascularity of advanced gastric carcinoma : evaluation by using power Doppler imaging."J Gastroenterol Hepatol. 16(in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kim SR, Kudo M, et al: "A case of disseminated extrahepatic carcinoma after US-guided biopsy and percutaneous ethanol injection therapy."Hepatology Research. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawasaki T, Kudo M, et al: "A case of localized primary sclerosing cholangitis mimicking intrahepatic bile duct cancer."Hepatology Research. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ding H, Kudo M, et al: "Detection of tumor parenchymal flow in hepatocellular carcinoma : utility of intermittent harmonic imaging in the early arterial phase with dual display mode."Radiology. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ding H, Kudo M, et al: "Diagnosis of pancreatic islet cell tumor : value of intermittent harmonic imaging"J Clin Ultrasound. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kudo M: "Hepatic peribiliary cysts : clinically harmless disease will potential risk due to increase in size and number."J Gastroenterol. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kudo M: "Cerebral vascular resistence in hepatic insufficiency."J Gastroenterol Hepatol. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kudo M: "Blood flow characteristics and hepatocellular carcinoma."Oncology. (in presss). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kudo M: "Color Doppler observation of efferent blood flow in liver tumors."In Dynamic Study of Efferent Tumor Blood Fow, Itai Y, Miura Y, eds, BRACCO, Italy. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ding H, Kudo M, et al: "Detection of intratumoral parenchymal flow in hepatic tumors : value of second harmonic imaging with a Galactose-based contrast agent."Hepatology Research. (in press). (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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