1999 Fiscal Year Final Research Report Summary
ミクログリアに発現しマクロファージに発現しない遺伝子の同定
| Project/Area Number |
10470158
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | National Institute of Neuroscience, National Center of Neurology and Psychiatry |
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Principal Investigator |
TABIRA Takeshi National Institute of Neuroscience, NCNP, Department of Demyelinating Disease and Aging, Head, 神経研究所・疾病研究第6部, 部長 (80112332)
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| Co-Investigator(Kenkyū-buntansha) |
INOUE Haruhisa National Institute of Neuroscience, NCNP, Department of Demyelinating Disease and Aging, Visiting Fellow, 神経研究所・疾病研究第6部, 流動研究員
SAWADA Makoto Fujita Health University, Institute for Comprehensive Medical Science, Associate Professor, 総合医学研究所, 助教授 (10187297)
TAKAHASHI Keikichi National Institute of Neuroscience, NCNP, Department of Demyelinating Disease and Aging, Section Chief, 神経研究所・疾病研究第6部, 室長 (40117148)
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| Project Period (FY) |
1998 – 1999
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| Keywords | MAGE / microglia / macrophage / SAGE / 遺伝子発現 |
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| Research Abstract |
We used a method for analyzing the qualitative and quantitative aspects of gene expression (MAGE) to compare expressed genes between microglia and macrophage. By sequencing 10,000 clones in each, we have found several genes that were significantly different between the two cell populations. Genes expressed highly in microglia included TSC36 (TGFβ-inducible gene), while genes expressed highly in macrophage included apolipoprotein E and cathepsin L.
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