• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2000 Fiscal Year Final Research Report Summary

Vasculitis in Kawasaki disease : the molecular and vascular biological studies

Research Project

Project/Area Number 10470183
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Pediatrics
Research InstitutionDepartment of Pediatrics and Child Health, Kurume University School of Medicine

Principal Investigator

KATO Hirohisa  Department of Pediatrics Kurume University School of Medicine, 医学部, 教授 (30080724)

Co-Investigator(Kenkyū-buntansha) NISHIYORI Atsushi  Department of Pediatrics Kurume University School of Medicine, 医学部, 講師 (30218226)
ISHII Masahiro  Department of Pediatrics Kurume University School of Medicine, 医学部, 講師 (90222950)
AKAGI Teiji  Department of Pediatrics Kurume University School of Medicine, 医学部, 講師 (80231801)
KAMIZONO Shintaro  Department of Pediatrics Kurume University School of Medicine, 医学部, 助手 (30261077)
Project Period (FY) 1998 – 2000
KeywordsKawasaki disease / tumor necrosis factor / endothelial function / nitric oxide / intravasucular ultrasound imaging / steroid pulse therapy / selectin family / Vascular
Research Abstract

The peripheral blood mononuclear cells of Kawasaki disease (KD) patients with coronary artery lesions produced higher levels of tumor necrosis factor (TNF)-alpha in response to bacterial products. None of the polymorphisms in the 5 flanking region of the TNF-alpha gene were related to KD.These results suggest that a genetic disposition towards overproduction of TNF-alpha in response to bacterial products may be involved in the pathogenesis of KD (Kamizono S, Kato H, et al. Pediatr Int. 1999). We investigated the coronary endothelial function using intracoronary infusions of acetylcholine and isosorbide dinitrate and evaluated vascular wall morphology using intravasucular ultrasound (IVUS) imaging long-term after KD.Long-term coronary artery lesions, even after aneurysm regression, may have impaired endothelial function and abnormal vascular wall morphology (Yamakawa R, Kato H, et al. JACC, 1998, Iemura M, Kato H, et al. Heart 2000). The steroid pulse therapy migt be useful in patients with intravenous immune globulin (IVIG)-resistant Kawasaki disease who experience prolonged fever. However, transient dilatation of the coronary artery was observed during steroid pulse therapy (Hashino K, Kato H, et al. Pediatr Int, in press). We investigated the relationship between the plasma levels of soluble forms of selectin family (P-, E-, and L- selectin) and the incidence of CAL in KD patients. Alterations in plasma selectin levels are important clinical molecular markers KD patients. E-selectin molecules may have potential as a predictor of incidence of CAL in patients with KD (Furui J Kurume Med J, in press). Vascular endothelial growth factor (VEGF) was involved in the pathogenesis of KD, especially in the developing of CAL.The VEGF may have possibility to become useful predictor of CAL in patients with IVIG resistant KD (Furui J, Kato H, et al. JACC 2001, abstract).

  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] Kamizono S,Kato H, et al.: "Analysis of tumor necrosis factor-alpha production and polymorphisms of the tumor necrosis factor-alpha gene in individuals with a history of Kawasaki disease."Pediatr Int. 41. 341-345 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sato N,Kato H, et al.: "Selective high dose gamma-globulin treatment in Kawasaki disease : assessment of clinical aspects and cost effectiveness."Pediatr Int. 41. 1-7 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iemura M,Ishii M,Kato H et al.: "Long-term consequences of regressed coronary aneurysms after Kawasaki Disease : vascular wall morphology and function"Heart. 83. 307-311 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Date Y,Kato H et al.: "Identification of a genetic risk factor for systemic juvenile rheumatoid arthritis in the 5-flanking region of the TNF alpha gene and HLA genes"Arthritis Rheum. 42. 2577-2582 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 加藤裕久,衛籐元寿: "成人になった川崎病の問題"Heart View. 3. 28-31 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akagi T,Ogawa S,Ino T,Echigo S,Tomita H,Ishii M,Kato H.: "Catheter interventional treatment in Kawasaki disease : a report from the japanese pediatric interventional cardiology investigation group."J Pediatr. 137. 181-186 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 加藤裕久: "内科学"杉本恒明. 2062 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kato H.: "Cardiology"Mosby,. 2500 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kamizono S, Kato H, et al.: "Analysis of tumor necrosis factor-alpha production and polymorphisms of the tumor nccrosis factor-alpha gene in individuals with a history of Kawasaki desase."Pediatr Int. Vol.41. 341-345 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato N, Kato H, et al.: "Selective high dose gamma-globlin treatment in Kawasaki disease : assessment of clinical aspects and cost effectiveness."Pediatr Int. Vol.41. 1-7 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iemura M, Ishii M, Kato H, et al.: "Long-term consequences of regressed voronary aneurysms after Kawasaki Disease : Vascular wall morphology and function."Heart. Vol.83. 307-311 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Date Y, Kato H, et al.: "Identification of a genetic resk factor for systemic juvenile rheumatoid arthritis in the 5-flanking region of the TNF alpha gene and HLA genes."Arthritis Rheum.. Vol.42. 2577-2582 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akgai T, Ogawa S, Ino T, Echigo S, Tomita H, Ishii M, Kato H.: "Catheter Interventional in Kawasaki disease : a report from the Japanese pediatric interventional cardiology i investigation group."J Pediatr. Vol.137. 181-186 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2002-03-26  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi