2000 Fiscal Year Final Research Report Summary
Influences of Mid-to-Long Term Nonpulsatile Circulation on Function and Structure of the Living Body
| Project/Area Number |
10470280
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | National Cardiovascular Center |
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Principal Investigator |
TAENAKA Yoshiyuki National Cardiovascular Center, Department of Artificial Organs, Director, 人工臓器部, 部長 (00142183)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEWA Yoshiaki National Cardiovascular Center, Department of Artificial Organs, Senior Staff, 人工臓器部, 室長 (20332405)
TATSUMI Eisuke National Cardiovascular Center, Department of Artificial Organs, Senior Staff, 人工臓器部, 室長 (00216996)
TSUKIYA Tomonori National Cardiovascular Center, Department of Artificial Organs, Staff, 人工臓器部, 室員 (00311449)
TAKANO Hisateru National Cardiovascular Center, Vice Director, 研究所, 副所長 (60028595)
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| Project Period (FY) |
1998 – 2000
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| Keywords | nonpulsatile circulation / Aorta / Circulatory control / Circadian rhythm / Chronomedicine / Vascular tonus / Autonomic nerve / Peripheral vessels |
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| Research Abstract |
Influences of mid-to-long term nonpulsatile circulation on function and structure of the living body were investigated especially in systemic circulation. Systemic vascular resistance was slightly decreased but other hemodynamics, peripheral organ, circulation, tissue metabolism and humoral circulatory control were not affected. Vascular tonus was maintained although constrictive function of the vascular system was reduced. Autonomic nervous sytem was also investigated. Circadian rhythm was well maintained except for rennin rhythm. Aortic wall thickness was reduced and atrophic changes of the wall smooth muscle cell was observed. Middle size arteries was not influence but peripheral vessels around the juxta-glommerular apparatus showed proliferation in the kidney.
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[Publications] Nishimura T, Tatsumi E, Takaichi S, Taenaka Y, Wakisaka Y, Nakatani T, Masuzawa T, Takewa Y, Nakamura M, Endo S, Nakata S, Takano H.: "Prolonged nonpulsatile left heart bypass with reduced systemic pulse pressure causes morphological changes in the aortic wall."Artificial Organs. 22 (5). 405-410 (1998)
Description
「研究成果報告書概要(欧文)」より
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