1999 Fiscal Year Final Research Report Summary
Disialosyl galactosyl globoside as an adhesion molecule expressed on renal and lung cancer cells and its relationship to adrenal gland metastatic potential
| Project/Area Number |
10470329
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Tohoku University |
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Principal Investigator |
SATOH Makoto Tohoku University, Graduate School of Med, Research Associate, 大学院・医学系研究科, 助手 (70282134)
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| Co-Investigator(Kenkyū-buntansha) |
SAITO Seiichi Tohoku University, Graduate School of Med, Research Associate, 医学部附属病院, 助手 (80235043)
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| Project Period (FY) |
1998 – 1999
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| Keywords | Renal Cell Carcinoma / Lung Cancer Cell / Adrenal Metastasis / Disialosyl Galactosylgloboside |
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| Research Abstract |
1)Adrenal metastasis from renal cell carcinoma : significance of adrenalectomy :
Adrenal metastases were investigated in 256 patients with RCC undergone nephrectomy from 1977 to 1996 in Tohoku University Hospital. The risk of adrenal metastasis did not correlate with T classification, grade, and tumor location. The adrenal gland was thought to be a "fertile soil" for spread of renal cell carcinoma. (Int J Urol. under revision)
2)Establishment of 4 new human renal cell carcinoma cell lines expressing globo-series ganglioside:
TOS-1, TOS-2, TOS-3 and TOS-3LN cell lines derived from human RCC tissues were established. These cell lines showed different expression pattern of globo-series ganglioside. (Tohoku J Exp Medicine : 189,95-105,1999.)
3)Association of renal cell carcinoma (RCC) antigen, disialylgalactosylgloboside (DSGG), with c-Src and Rho A in clustered domains at the surface membrane :
DSGG is clustered in RCC to form a microdomain in which it is closely associated with c-Src, Rho A and FAK and may constitute a functional unit. The functional organization of such units may be essential in determining malignant properties of RCC cells. (Int J Oncol : 16,529-536,2000.)
4)DSGG mediates adhesion of RCC and lung cancer cells to certain adrenal medulla target cells :
DSGG expressed RCC or lung cancer cell lines showed strong adhesion to adrenal gland tissues. This adhesion process may initiate preferential adrenal metastasis.
(IGAKU NO AYUMI : 194, 841-844,2000)
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