2000 Fiscal Year Final Research Report Summary

PATHOGENESIS OF KELOID WITH FOLLICULAR SEGMENTS

Research Project

Project/Area Number	10470377
Research Category	Grant-in-Aid for Scientific Research (B).
Allocation Type	Single-year Grants
Section	一般
Research Field	Plastic surgery
Research Institution	KANSAI MEDICAL UNIVERSITY
Principal Investigator	OGAWA Yutaka KANSAI MEDICAL UNIVERSITY, MEDICINE, PROFESSOR, 医学部, 教授 (70026912)
Co-Investigator(Kenkyū-buntansha)	DOI Hideaki KANSAI MEDICAL UNIVERSITY, MEDICINE, ASSISTANT, 医学部, 助手 (10227689)
Project Period (FY)	1998 – 2000
Keywords	KELOID / IMMUNUSUPPRESSER / LICHEN PILARIS / FIBROBLAST / APOTOSIS / ANTIBIOTICS / TNF α / IL6
Research Abstract	Keloid revealed to be combined with lichen pilaris in high frequency. 62.8% of keloid patients had lichen pilaris on their arms. The other hand only 1.1% of non-keloid control showed combination of lichen pilaris. The high rate of the coexistence suggests that the hair-related disorder may be related to the etiological factor of keloid formation. The growth of human fibroblast was inhibited with various kinds of antibiotics and immunodepressant agents. The high depression group included Cefazolin, Cefalotin, Cefotiam, Flomoxef et al, the moderate depression group were piperacillin, Gentamycin and the low depression group were Vancomycin, Teichoplanin, Minomycine et. Apotosis was found more on the active part of the keloid tissue than the inactive part. IL6 was found to be promoting for the hair growth in rat experiment. Topical injection of IL6 proved the fact.